Friday 
 
 
12:00 pm - 4:00 pm 
	
Arrival and Check-in
 
 
						
2:30 pm - 4:00 pm 
	
Poster Session 
 
 
						
4:00 pm - 4:15 pm 
	
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
 
 
						
4:15 pm - 6:00 pm 
	
Expanding the Chemical Space of Metalloenzymes 
 
 
 
						
4:15 pm - 4:20 pm 
	
Introduction by Discussion Leader
 
 
						
4:20 pm - 4:35 pm 
	
"Chemical Modification of Complex Fe–S Clusters for Novel Spectroscopic Studies" 
 
 
 
						
4:35 pm - 4:40 pm 
	
Discussion
 
 
						
4:40 pm - 4:55 pm 
	
"Zinc Fingers are a General Target of H2 S for Persulfidation" 
 
 
 
						
4:55 pm - 5:00 pm 
	
Discussion
 
 
						
5:00 pm - 5:15 pm 
	
"Using the Natural Protein, Lanmodulin (LanM), to Overcome the Subtle Chemical Differences Among the Rare Earth Elements" 
 
 
 
						
5:15 pm - 5:20 pm 
	
Discussion
 
 
						
5:20 pm - 5:35 pm 
	
"Aziridine Formation Enabled by Non-Heme Iron Enzymes: Identification and Mechanistic Study" 
 
 
 
						
5:35 pm - 5:40 pm 
	
Discussion
 
 
						
5:40 pm - 5:55 pm 
	
"Mechanistic Interrogations of the Azidation Reaction in Fe(II)/2-Oxoglutarate-Dependent Halogenases" 
 
 
 
						
5:55 pm - 6:00 pm 
	
Discussion
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Homeostasis and Regulation of Metals in Biology 
 
 
 
						
7:30 pm - 7:35 pm 
	
Introduction by Discussion Leader
 
 
						
7:35 pm - 7:50 pm 
	
"Identification of a Biosynthetic Pathway for a Novel Lanthanide-Chelator in Methylobacterium extorquens AM1" 
 
 
 
						
7:50 pm - 7:55 pm 
	
Discussion
 
 
						
7:55 pm - 8:10 pm 
	
"Elucidating the Mechanism of Oxygen Sensing in the Globin Coupled Sensor Proteins" 
 
 
 
						
8:10 pm - 8:15 pm 
	
Discussion
 
 
						
8:15 pm - 8:30 pm 
	
"A Tale of Two RNA-Binding Zinc Finger Proteins: Linking Metalation to Reactivity and Function" 
 
 
 
						
8:30 pm - 8:35 pm 
	
Discussion
 
 
						
8:35 pm - 8:45 pm 
	
"Uncovering the Molecular Mechanisms Linking Iron Misregulation and Diabetes" 
 
 
 
						
8:45 pm - 8:50 pm 
	
Discussion
 
 
						
8:50 pm - 9:05 pm 
	
"In vitro Maturation of Nickel Superoxide Dismutase Reveals a Role for Cytoplasmic Histidine in Processing and Metalation" 
 
 
 
						
9:05 pm - 9:10 pm 
	
Discussion
 
 
						
9:10 pm - 9:25 pm 
	
"Characterization of a Novel Methanogen Radical SAM/SPASM Domain Enzyme" 
 
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Saturday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
8:30 am - 9:00 am 
	
Group Photo
 
 
						
9:00 am - 12:30 pm 
	
Electronic Insights from Spectroscopy, Computation, and Structure 
 
 
 
						
9:00 am - 9:10 am 
	
Introduction by Discussion Leader
 
 
						
9:10 am - 9:30 am 
	
"Non-Innocent Sulfur in Organometallic Chemistry of Fe–S Clusters" 
 
 
 
						
9:30 am - 9:35 am 
	
Discussion
 
 
						
9:35 am - 9:50 am 
	
"Spectroscopic Quantification of O2  Isotopologues by EPR: a Method of Investigating Water Oxidation Catalyst Mechanisms" 
 
 
 
						
9:50 am - 9:55 am 
	
Discussion
 
 
						
9:55 am - 10:15 am 
	
"Resolving Methane Oxidation: and XES Study of Methane Monooxygenase and Fe Model Compounds" 
 
 
 
						
10:15 am - 10:20 am 
	
Discussion
 
 
						
10:20 am - 10:50 am 
	
Coffee Break
 
 
						
10:50 am - 11:05 am 
	
"Pyruvate Formate-Lyase Activating Enzyme: A Catalytically Competent 5'-Deoxyadenosyl Radical Intermediate Abstracting a H-atom from a Natural Substrate Mimic" 
 
 
 
						
11:05 am - 11:10 am 
	
Discussion
 
 
						
11:10 am - 11:25 am 
	
"Towards Time Resolved Structural Studies of Tryptophan 2,3-dioxygenase" 
 
 
 
						
11:25 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 11:45 am 
	
"Probing O2  Activation and In Vivo Metalation of a Mn/Fe Oxidase" 
 
 
 
						
11:45 am - 11:50 am 
	
Discussion
 
 
						
11:50 am - 12:05 pm 
	
"Examination of the Conformation – Electronic Structure – Product Relationship in Non-Canonical Heme Oxygenase Catalyzed Reactions" 
 
 
 
						
12:05 pm - 12:10 pm 
	
Discussion
 
 
						
12:10 pm - 12:25 pm 
	
"Using Advanced EPR Spectroscopy to Map out the Histidine-Brace in Lytic Polysaccharide Monooxygenases" 
 
 
 
						
12:25 pm - 12:30 pm 
	
Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:15 pm - 6:00 pm 
	
Synthetic Inorganic Chemistry as a Window into Biology 
 
 
 
						
4:15 pm - 4:20 pm 
	
Introduction by Discussion Leader
 
 
						
4:20 pm - 4:35 pm 
	
"Synthetic Fe–S Clusters Supported by Sterically Encumbering Ligands" 
 
 
 
						
4:35 pm - 4:40 pm 
	
Discussion
 
 
						
4:40 pm - 4:55 pm 
	
"Significance of Intramolecular Hydrogen Bonding on the Properties and Reactivity of the Mn(III)-Hydroxo Complexes" 
 
 
 
						
4:55 pm - 5:00 pm 
	
Discussion
 
 
						
5:00 pm - 5:15 pm 
	
"Nitrite Reduction Catalyzed by a Nonheme Fe(II)-Nitro Complex" 
 
 
 
						
5:15 pm - 5:20 pm 
	
Discussion
 
 
						
5:20 pm - 5:35 pm 
	
"Temperature Dependent C-S versus C-OH Bond Formation by Nonheme FeIII(OH)(SAr) Complexes: Relevance to Isopenicilin N Synthase (IPNS)" 
 
 
 
						
5:35 pm - 5:40 pm 
	
Discussion
 
 
						
5:40 pm - 5:55 pm 
	
"Reactive High-spin Iron(IV)-oxo Sites through Dioxygen Activation in a Metal–organic Framework" 
 
 
 
						
5:55 pm - 6:00 pm 
	
Discussion
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:00 pm - 7:30 pm 
	
Evaluation Period 
Complete the GRS Evaluation Forms; Election of Future Chair(s) 
 
 
						
7:30 pm - 9:30 pm 
	
Repurposing Nature: From Design to Evolution 
 
 
 
						
7:30 pm - 7:35 pm 
	
Introduction by Discussion Leader
 
 
						
7:35 pm - 7:50 pm 
	
"Switchable Artificial Metalloproteins to Probe Conformational Control in Enzyme Function" 
 
 
 
						
7:50 pm - 7:55 pm 
	
Discussion
 
 
						
7:55 pm - 8:10 pm 
	
"Peroxygenation and Oxidative Functionalization by Artificial Cu Proteins (ArCuPs)" 
 
 
 
						
8:10 pm - 8:15 pm 
	
Discussion
 
 
						
8:15 pm - 8:25 pm 
	
"Design Principle for Site-Selective Hydroxylation in a Pair of Rieske Oxygenases" 
 
 
 
						
8:25 pm - 8:30 pm 
	
Discussion
 
 
						
8:30 pm - 8:45 pm 
	
"Computational Design of Metal Centers Along De Novo Protein Interfaces" 
 
 
 
						
8:45 pm - 8:50 pm 
	
Discussion
 
 
						
8:50 pm - 9:05 pm 
	
"Hydrophobic Environments Govern Mn-dependent versus Ni-dependent Activity of Quercetin 2,4-dioxygenase" 
 
 
 
						
9:05 pm - 9:10 pm 
	
Discussion
 
 
						
9:10 pm - 9:25 pm 
	
"Structural and Mechanistic Determinants of ddhNTP Catalysis by the Ancient Antiviral Enzyme, Viperin" 
 
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Sunday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Mechanisms in Metalloenzymology 
 
 
 
						
9:00 am - 9:05 am 
	
Introduction by Discussion Leader
 
 
						
9:05 am - 9:25 am 
	
"Paradigm Shift on the Evolution of Multiheme Cytochromes: Grafting and Pruning of Protein Modules Across Time" 
 
 
 
						
9:25 am - 9:30 am 
	
Discussion
 
 
						
9:30 am - 9:50 am 
	
"Metalloenzyme-Catalyzed Transformations during the Biosynthesis of 3-Thia-a-Amino Acids" 
 
 
 
						
9:50 am - 9:55 am 
	
Discussion
 
 
						
9:55 am - 10:15 am 
	
"Influences of the Outer Coordination Sphere on Cytochrome P460 Structure and Function" 
 
 
 
						
10:15 am - 10:20 am 
	
Discussion
 
 
						
10:20 am - 10:50 am 
	
Coffee Break
 
 
						
10:50 am - 11:05 am 
	
"Non-Canonical Iron-Sulfur Clusters in an Electron Bifurcating Hydrogenase" 
 
 
 
						
11:05 am - 11:10 am 
	
Discussion
 
 
						
11:10 am - 11:25 am 
	
"Primary C-H Bond Hydroxylation at a Heterobimetallic Fe/Mn Cofactor" 
 
 
 
						
11:25 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 11:45 am 
	
"Radical-Polar Crossover Mechanism of Ethylene Forming Enzyme (EFE) and Rational Perturbation of its Two Branch Points" 
 
 
 
						
11:45 am - 11:50 am 
	
Discussion
 
 
						
11:50 am - 12:05 pm 
	
"How Substrate and Anion Binding Control Reactivity in Non-heme Iron Halogenases" 
 
 
 
						
12:05 pm - 12:10 pm 
	
Discussion
 
 
						
12:10 pm - 12:25 pm 
	
"Polysaccharide Monooxygenase MtPMO9E Requires a Distant Tyrosine Resides to Activate Molecular Oxygen" 
 
 
 
						
12:25 pm - 12:30 pm 
	
Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:15 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Keynote Session 
Joint Session with the Metals in Biology GRC 
 
 
						
9:30 pm - 11:00 pm 
	
Poster Session 
Joint Poster Session with the Metals in Biology GRC 
 
 
						
	Monday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am 
	
Seminar Concludes