Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Keynote Session: Dynamic Genome Control Mechanisms in Neuronal Longevity
3:15 pm - 3:45 pm
"Dynamic Genome Control Mechanisms in Neuronal Longevity"
3:45 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Foundational Units: Aging at the Molecular, Organelle, and Cellular Level
5:30 pm - 5:40 pm
"Amyloid Beta Precursor Protein Contributes to Brain Aging and Learning Decline in Short-Lived Turquoise Killifish (Nothobranchius furzeri)"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
"Decoding the Chromatin Landscape of Reproductive Aging: Insights from Granulosa Cells"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
"KCC2 as a Novel Pharmacological Target for Reversing Cognitive Impairment in Elderliness"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
"Transcriptional Reprogramming to Reverse Aging-Associated Transcriptional Dysregulation in Neurons"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Mitochondrial Transplantation Improves Skeletal Muscle Bioenergetics in Mouse and Rat Models of Aging"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
"Novel Tools for the Measurement and Manipulation of Neuronal Lysosomal pH Reveals a Link Between Acidification and Longevity"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"Revealing the Cell Biology of the cGAS-STING Innate Immune Pathway in Brain Aging Using Novel Biosensors for Super-Resolution Imaging"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Mitochondrial Dynamics in Aging: Overexpression of Mitochondrial Fission or Mitochondrial Fusion Genes Extends Longevity in C. elegans "
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Interconnectivity: Inter-Tissue Communication and Systemic Aging
9:00 am - 9:10 am
"Adipose Derived-Stem Cells (ASCs) Aging is Mediated by AMPK/SIRT1/PPARg Signalling Pathway and Extracellular Vesicles: Interplay Between the Niche and Metabolic Regulators"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
"Plantaricin A Identified in Human Circulation as a Microbial Contributor to Skeletal Muscle Ageing"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Nucleoside Reverse Transcriptase Inhibitor Therapy Reduces Age-Associated Myeloid Skewing and Modulates Microenvironmental Dynamics in the Aged Bone Marrow"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Intrinsic Drivers of Ageing Revealed by Single-Cell Profiling of The Microbiome's Role in Modulating Chronic Inflammation and Age-Associated B Cell Expansion"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Cellular Senescence in Endometriosis: Mechanistic Links to Disease Progression, Accelerated Biological Aging, and Senescence-Targeted Therapeutic Strategies"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"In Vivo Functional Characterisation of Rare Protein-Altering Genetic Variants Identified in Long-Lived Families"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
"Sex and Age-Dependent Regulation of Hepatic Ketogenesis via PPARα - NF-κB Crosstalk Revealed Through Integrated Proteomic and Lipidomic Profiling"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"Predicting Lifespan-Extending Compounds in Mice with Machine Learning"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: What Comes Next: Navigating Careers in the Aging Field
1:30 pm - 2:30 pm
Panel Discussion
What Comes Next: Navigating Careers in the Aging Field
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
