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Biomechanics in Vascular Biology and Disease

Gordon Research Conference

Biomechanics and Mechanobiology of Cardiovascular Disease and Rejuvenation

July 20 - 25, 2025

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GRC Education Requirements: Undergraduates or those who have not obtained a bachelor's degree in science/engineering (or acceptable equivalent) are not eligible to apply to attend Gordon Research Conferences or Seminars.

Chairs

and

Vice Chairs

and

Ventura Beach Marriott

2055 Harbor Boulevard

Ventura, California, United States

Venue and Travel Information

Application Information

Applications for this meeting must be submitted by June 22, 2025. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the conference chair if more seats become available due to cancellations.

Conference Description

The Biomechanics in Vascular Biology and Disease GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes an array of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

The Abstract Submission is now open. The submission deadline is March 3, 2025.

Related Meeting

This GRC will be held in conjunction with the "Biomechanics in Vascular Biology and Disease" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Biomechanics and Mechanobiology Discussion Leaders: and
7:40 pm - 7:50 pm	Introduction by Discussion Leader
7:50 pm - 8:20 pm	"Model-Guided Treatment Planning in Pediatric Cardiology"
8:20 pm - 8:40 pm	Discussion
8:40 pm - 9:10 pm	"The Role of Cell-Cell Junctions in Endothelial Fluid Shear Stress Mechanotransduction"
9:10 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Mechanosensors and Signal Transduction Discussion Leaders: and
9:00 am - 9:15 am	"Flow-Induced Reprogramming of Endothelial Cells, Fire, in Atherosclerosis Development"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	"Vascular PIEZO Mechanoreceptors"
9:35 am - 9:40 am	Discussion
9:40 am - 9:55 am	"Lipid Regulation of Endothelial Stiffness in Obesity and Aging"
9:55 am - 10:00 am	Discussion
10:00 am - 10:15 am	"Mechanosensitive Notch1 Transducer in the Endothelium"
10:15 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:05 am	"Disturbed Flow Downregulates LATS1/2, Driving Endothelial Senescence-Associated Stemness (SAS) and Atherothrombotic Lesion Formation"
11:05 am - 11:10 am	Discussion
11:10 am - 11:25 am	"Viscoelastic Property and Barrier Role of the Glycocalyx in Cells"
11:25 am - 11:30 am	Discussion
11:30 am - 11:45 am	"Distinct Regulation of Gene Expression by Laminar and Disturbed Flow in Human Vascular Endothelial Cells"
11:45 am - 11:50 am	Discussion
11:50 am - 12:05 pm	"Accelerated Elastin and Collagen Remodeling in Sickle Cell Disease: Biomechanical and Biochemical Stimuli"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	"Kindlin-2 in the Mechanical Regulation of Vascular Development and Disease"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Cardiovascular Hemodynamics and Resilience Discussion Leaders: and
7:30 pm - 7:45 pm	"The Plaque Hypothesis: Fundamental Pathobiology of Coronary Atherosclerosis and Clinical Implications for Chronic Ischemic Heart Disease Management"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:05 pm	"Endothelial Piezo1 Channel Mediates Mechano-feedback Control of Brain Blood Flow"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	"Vascular Smooth Muscle Cell Resilience and Aging"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	"The Cardiac Microvasculature Responses in the Context of Ageing"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	"Reversal of Cerebrovascular Anomalies in a Zebrafish Model of Vein of Galen Aneurysm"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	"Deciphering Aortic Aging: Lessons from Mouse Models"
9:25 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Biomechanics and Mechanobiology of Aneurysms and Disease Discussion Leaders: and
9:00 am - 9:15 am	"Mechanobiological Control of Vascular Adaptation and Disease Progression"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	"Digital Twins: Biophysical Targeted based Drug Delivery to Brain Aneurysms"
9:35 am - 9:40 am	Discussion
9:40 am - 9:55 am	"Deep Learning Generation of Intracranial Aneurysm Geometries to Specific Clinical Morphological Parameters for Fluid Dynamics Investigations"
9:55 am - 10:00 am	Discussion
10:00 am - 10:15 am	"Mechanotransducers for Endothelial Homeostasis"
10:15 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:05 am	"Diagnosing Heart Failure from Arterial Pulse Wave Characteristics"
11:05 am - 11:10 am	Discussion
11:10 am - 11:25 am	"Mechanical Activation of Endothelial Reprograming by an Interleukin-1 Receptor Mechanism"
11:25 am - 11:30 am	Discussion
11:30 am - 11:45 am	"Pulmonary Hemodynamics and Mechanobiology: From Bench to Bedside"
11:45 am - 11:50 am	Discussion
11:50 am - 12:05 pm	"Dual Roles of Mechanosensitive Platelets in Aneurysm Initiation and Progression"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	"The Role Endothelial PGC1a in AAA"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Valvular Biomechanics and Mechanobiology Discussion Leaders: and
7:30 pm - 7:45 pm	"Cell Mechanics in the Process of Endocardial Remodeling and Cardiac Valve Morphogenesis"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:05 pm	"Mechanics and Mechanobiology of Vascular Calcification"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	"Mechanical and Cellular Asymmetry in Aortic Valve Physiology and Disease"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	"Role of Angiotensin Signaling in Mediating Aortic Valve Mechanics and Disease"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	"Low Input Proteomics of Single Mouse Valves: Functional Imaging Integration with Target Discovery"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	"Mechanobiological Regulation of Fetal Outflow Tract Morphogenesis"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Developmental and Stem Cell Biomechanics Toward Precision Medicine Discussion Leaders: and
9:00 am - 9:15 am	"Matrix Mechanics Regulation of Vascular Formation and Homeostasis"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	"Dissecting Mechanosignaling in hiPSC Disease Models"
9:35 am - 9:40 am	Discussion
9:40 am - 9:55 am	"Reprogramming Mechanogenetics for Cell Therapy"
9:55 am - 10:00 am	Discussion
10:00 am - 10:15 am	"Mechanoenzyme and Cell Mechanointelligence"
10:15 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:05 am	"Discovery of Inflammation-Dependent Mechanisms of Cardiovascular Calcification"
11:05 am - 11:10 am	Discussion
11:10 am - 11:25 am	"Extracellular Matrix Mechanics on Endothelial Phenotype"
11:25 am - 11:30 am	Discussion
11:30 am - 11:45 am	"Precision Nanomedicine Targeting Novel Endothelial Mechano-Sensing Mechanisms to Treat Vascular Diseases"
11:45 am - 11:50 am	Discussion
11:50 am - 12:05 pm	"Mechanotransduction in Cerebral Small Vessel Disease"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	"Dynamic Phenotypic Transitions of Smooth Muscle Cells in Aortic Disease Progression"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Plaque Biomechanics in Atherosclerosis Discussion Leaders: and
7:30 pm - 7:45 pm	"EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:05 pm	"Imaging Carotid Plaque Structure to Help Predict Rupture"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	"Biomechanics and Sex-Related Differences in Atherosclerosis"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	"ACE2, Shear Stress, and EC Biology"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	"Quantifying the Impact of Disturbed Flow and Arterial Stiffening on Mechanotransduction in Endothelial Cells"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	"RBC-Membrane Adhesive Tangles (MATs): A Biomechanical Catalyst for Atherosclerotic Plaque Thrombosis"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Cardiovascular Imaging and Computation Discussion Leaders: and
9:00 am - 9:15 am	"Photoacoustic, Light-Speed, and Quantum Imaging"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	"Assessment of Prothrombotic Hemodynamics in the Carotid Arteries in Subjects Who Have Had a Stroke or TIA"
9:35 am - 9:40 am	Discussion
9:40 am - 9:55 am	"Quantifying Ascending Aortic Aneurysm Risk Through Magnetic Resonance Imaging-Based Biomechanics: A Machine Learning Approach"
9:55 am - 10:00 am	Discussion
10:00 am - 10:15 am	"Microstructurally Informed Mechanical Models for Fibrin and Collagen Networks: Can We Predict Mechanical Behaviour and Failure"
10:15 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:05 am	"Towards a ‘Digital Twin’ for Stroke Prevention: A Microengineered Carotid Artery Platform for Personalized Thrombotic Risk Assessment and Drug"
11:05 am - 11:10 am	Discussion
11:10 am - 11:25 am	"Modeling the Vascular Microenvironment: Implications in Cardiac Health"
11:25 am - 11:30 am	Discussion
11:30 am - 11:45 am	"Characterization of Cardiac Morphogenesis and Contractile Function with Cellular Resolution"
11:45 am - 11:50 am	Discussion
11:50 am - 12:05 pm	"3D Imaging of Coronary Vascular Architecture in the Mouse Model of Repetitive Ischemia"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	"On the Role of Calcification in the Pathology of Cerebral Aneurysms"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Cardiovascular Biomechanics and Mechanobiology Discussion Leaders: and
7:30 pm - 7:45 pm	"Thera-Mechanics: From Force to Therapy"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:05 pm	"Latest insights into patient specific coronary artery tree shear stress using machine learning"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	"Flow Modulation of Endothelial Ca2+ Signaling Dynamics"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	"Harnessing Ribonucleoprotein Complexes to Engineer Cell Mechanics"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	"Horizontal Mitochondrial Transfer from Endothelial Cells under Mechanochemical Stress"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	"Beyond Flow Patterns: Paving the Way Toward Mechanobiological Insights in Cardiovascular Disease"
9:25 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

School of Biomedical Engineering, The University of Sydney

Conference Links

Conference History Biomechanics in Vascular Biology and Disease (GRS) Contribute Financially to This Conference

Conference Fees

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Poster Information

Poster sessions are an integral part of the our conferences, and offer all conferees an opportunity to discuss their research.

Preparing your GRC poster

Funding Opportunities

Financial assistance is available beginning in 2026 for qualified applicants through the Carl Storm Opportunity Fellowships program. Learn more.

Registration Fees

Conferee Single Room:

$1,720.00

Conferee Shared Room:

$1,375.00

Conferee Off-Site:

$945.00

Guest Single Room:

$1,530.00

Guest Shared Room:

$1,185.00

Guest Off-Site:

$755.00

Child 4-12 yrs Shared Room:

$593.00

Child 4-12 yrs Off-Site:

$378.00

Child Under 4 yrs Shared Room:

Free

Child Under 4 yrs Off-Site:

Free

Additional Fee Info

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