Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Mechanosensitive Membrane Domains Regulate Calcium Entry in Arterial Endothelial Cells to Protect against Inflammation
3:45 pm - 3:55 pm
Introduction by Discussion Leader
3:55 pm - 4:20 pm
"Mechanosensitive Membrane Domains Regulate Calcium Entry in Arterial Endothelial Cells to Protect against Inflammation"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanosensors, Signal Transduction, and Valvular Biomechanics and Mechanobiology
7:30 pm - 7:40 pm
"Substrate Stiffness Induces Senescence via the Secretion of YBX1 by Endothelial Cells"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Endothelial Cell Elongation Requires Acetylation of Microtubules in Response to Shear Strress"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Endothelial Restoration of CAD GWAS Gene PLPP3 by Nanomedicine Suppresses Mechano-Sensitive YAP/TAZ Activity and Reduces Atherosclerosis In Vivo"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Hyperglycemia-Mediated Cardiovascular Biomechanical Changes, and Their Potential for Rescue via SGLT2 Inhibition, Are Influenced by Sex and Rate of Disease Onset"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Mechano-Biological Insights Into Cancer-Associated Thrombosis"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Shear Flow-Induced Mechano-Osmotic Signalling Is Required for Nuclear Remodelling and Vascular Homeostasis"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Habitual Exercise Modulates Neuro-Immune Interaction to Mitigate Aortic Stiffness"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Fibrin Polymerization by Staphylococcus Aureus Varies in Human Plasma"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Cardiovascular Imaging, Models, and Computation / Clinical Applications of Cardiovascular Biomechanics and Mechanobiology
9:00 am - 9:10 am
"Endothelial GATA4 in Atherosclerosis Progression"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
"Disturbed Flow Induces Reprogramming of Endothelial Cells to Immune-like and Foam Cells under Hypercholesterolemia during Atherogenesis"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Targeting Glycocalyx-Mediated Endothelial Cell Mechanotransduction and Endothelial Dysfunction to Prevent Cardiovascular Disease"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Linking Aortic Microstructural Remodeling to Mechanical Behavior During Pregnancy: An Image-based Analysis of the Extracellular Matrix and Cellular Morphology"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Local Quantification of the Mean Microstructural Deformation of the Myocardium In Vivo using DENSE MRI and a Novel Set of Strain Attributes"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Quantitative Susceptibility Mapping for the Risk Stratification of Carotid Plaque Rupture"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
"Determining Hemodynamic Tolerances of Normal Cardiac Morphogenesis"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"Understanding the Impact of Aortic Seal Zone Geometry on Endoleak Formation By Connecting Lubrication Flow and Wrinkling Theories"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Navigating Academia and Beyond: Strategies for a Successful Career
1:30 pm - 2:30 pm
Panel Discussion
Academic Mentorship
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
