| Sunday evening, June 14: Protein Engineering |
| Discussion Leader: Thomas Muir
|
| 7:15 p.m. |
|
Opening Remarks |
| 7:30 p.m. |
James A. Wells |
What's shaking at protein interfaces? |
| 8:10 p.m. |
|
Discussion |
| 8:20 p.m. |
Francine B. Perler |
Protein splicing |
| 9:00 p.m. |
|
Discussion |
| 9:10 p.m. |
|
Break |
| 9:20 p.m. |
Kevan M. Shokat |
New chemical approaches for tracing cellular signal transduction cascades |
| 10:00 p.m. |
|
Discussion |
| Monday morning, June 15: Membranes |
| Discussion Leader: Hitoshi Ishida |
| 8:30 a.m. |
Peter A. Petillo |
Towards an artificial synovial fluid |
| 9:10 a.m. |
|
Discussion |
| 9:20 a.m. |
Toyoki Kunitake |
Recognition of aqueous dipeptides by peptide monolayers at the air-water interface |
| 10:00 a.m. |
|
Discussion |
| 10:10 a.m. |
|
Break |
| 10:40 a.m. |
Paul B. Savage |
Development of new potent sensitizers of Gram-negative bacteria |
| 11:00 a.m. |
|
Discussion |
| 11:10 a.m. |
Peter Kim |
Viral membrane fusion |
| 11:50 a.m. |
|
Discussion |
| 12:30 a.m. |
|
Lunch |
| Monday afternoon, June 15 |
| 4-6 p.m. |
|
First Poster Session |
| Monday evening, June 15: Molecular Recognition |
| Discussion Leader: Andrea Cochran
|
| 7:30 p.m. |
John C. Sherman |
Templation and encapsulation in the formation of molecular prisons and reversible capsules |
| 8:10 p.m. |
|
Discussion |
| 8:20 p.m. |
Robert S. McDowell |
Peptide inhibitors of protein-protein binding event: Mimics of the native epitope |
| 9:00 p.m. |
|
Discussion |
| 9:10 p.m. |
|
Break |
| 9:20 p.m. |
Stephen W. Fesik |
SAR by NMR: A method for discovering high affinity ligands for proteins |
| 10:00 p.m. |
|
Discussion |
| Tuesday morning, June 16 : Enzymology |
| Discussion Leader: Larry Hardy
|
| 8:30 a.m. |
Ann L. Jackman |
Targeting thymidylate synthase: An anticancer drug discovery approach |
| 9:10 a.m. |
|
Discussion |
| 9:20 a.m |
Robert M. Stroud |
Towards new paradigms in drug design for proteases and thymidylate synthase |
| 10:00 a.m. |
|
Discussion |
| 10:10 a.m. |
|
Break |
| 10:40 a.m. |
Nicole S. Sampson |
Peptide inhibitors of fertilization: Identification of a target receptor |
| 11:00 a.m . |
|
Discussion |
| 11:10 a.m. |
Toni M. Kutchan |
Alkaloids: Plant bioorganic chemistry with a biotechnological potential |
| 11:50 a.m. |
|
Discussion |
| 12:30 p.m. |
|
Lunch |
| Tuesday afternoon, June 16 |
| 4-6 p.m. |
|
First Poster Session |
| Tuesday evening, June 16: Combinatorial (Bio)Chemistry |
| Discussion Leader: David J. Austin
|
| 7:30 p.m. |
Bruce E. Eaton |
Stereospecific RNA catalyzed conjugation to a hydrophobic protease inhibitor |
| 8:10 p.m. |
|
Discussion |
| 8:20 p.m. |
Peter F. Leadlay |
Modular polyketide synthases |
| 9:00 p.m. |
|
Discussion |
| 9:10 p.m. |
|
Break |
| 9:20 p.m. |
Philip A. Patten |
Evolution of human alpha-interferon using DNA shuffling |
| 10:00 p.m. |
|
Discussion |
| Wednesday morning, June 17: Protein Design |
| Discussion Leader: Annelise E. Barron
|
| 8:30 a.m. |
Lynne J. Regan |
The design of proteins with novel structures and activities |
| 9:10 a.m. |
|
Discussion |
| 9:20 a.m. |
Stephen L. Mayo |
Protein design by inverse folding
|
| 10:00 a.m. |
|
Discussion |
| 10:10 a.m. |
|
Break |
| 10:40 a.m. |
Adrian Whitty |
Interaction affinity between cytokine receptor components on the cell surface |
| 11:00 a.m. |
|
Discussion |
| 11:10 a.m. |
Samuel H. Gellman |
Heteropolymer folding: Proteins and beyond |
| 11:50 a.m. |
|
Discussion |
| 12:30 a.m. |
|
Lunch |
| Wednesday afternoon, June 17 |
| 4-6 p.m. |
|
Second Poster Session |
| Wednesday evening, June 17: Carbohydrates |
| Discussion Leader: Randall L. Halcomb
|
| 7:30 p.m. |
Carolyn R. Bertozzi |
Glycoform engineering in glycobiology |
| 8:10 p.m. |
|
Discussion |
| 8:20 p.m. |
Ari Helenius |
The role of lectins in glycoprotein folding |
| 9:00 p.m. |
|
Discussion |
| 9:10 p.m. |
|
Break |
| 9:20 p.m. |
Barbara Imperiali |
Chemistry and biology of asparagine-linked protein glycosylation |
| 10:00 p.m. |
|
Discussion |
| Thursday morning, June 18: Receptors |
| Discussion Leader: Stephen V. Frye
|
| 8:30 a.m. |
Robert J. Fletterick |
How binding activates the thyroid hormone receptor |
| 9:10 a.m. |
|
Discussion |
| 9:20 a.m. |
Thomas S. Scanlan |
Nuclear receptor ligands and signalling |
| 10:00 a.m. |
|
Discussion |
| 10:10 a.m. |
|
Break |
| 10:40 a.m. |
Robert F. Standaert |
Toward non-peptidic nuclear localization signals |
| 11:00 a.m. |
|
Discussion |
| 11:10 a.m. |
Timothy M. Willson |
The chemistry and biology of orphan nuclear receptors |
| 11:50 a.m. |
|
Discussion |
| 12:30 a.m. |
|
Lunch |
| Thursday afternoon, June 18 |
| 4-6 p.m. |
|
Second Poster Session |
| Thursday evening, June 18: Catalysis |
| Discussion Leader: Hung-Wen Liu
|
| 7:30 p.m. |
|
Business Meeting Discussion, Evaluation, 2000 Election |
| 8:00 p.m. |
Daniel Herschlag |
Direct demonstration of the catalytic role of binding interactions in enzymatic reactions |
| 8:40 p.m. |
|
Discussion |
| 8:50 p.m. |
|
Break |
| 9:00 p.m. |
Thomas C. Bruice |
Ground states and transition states in intramolecular and enzymatic reactions |
| 9:40 p.m. |
|
Discussion |
