| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:15 pm | Welcoming Remarks |
| 7:30 pm - 9:30 pm | MATERIALS, SENSORS AND MOLECULAR MACHINES |
| Discussion Leader: Chris Schafmeister (U. Pittsburgh) |
| 7:30 pm - 8:00 pm | David Tirrell (Caltech)
"A Polymer Chemist's View of Protein Synthesis and Design" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Dek Woolfson (University of Sussex)
"Constructing Peptide-Based Materials and Nanoscale Structures from the Bottom Up" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Eric Anslyn (U.T. Austin)
"Organic Chemistry Approaches to Single and Multi-Analyte Sensing" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Photo Session |
| 9:00 am - 12:30 pm | OUTSIDE THE GENETIC CODE |
| Discussion Leader: Tarun Kapoor (Rockefeller) |
| 9:00 am - 9:30 am | Virginia Cornish (Columbia)
"Co-opting the Ribosome for Display of Peptidomimetics" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Tom Muir (Rockefeller)
"Cutting and Pasting Proteins" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:35 am - 11:05 am | Peter Belshaw (U. Wisconsin-Madison)
"Light-Directed Combinatorial Synthesis" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:45 am | Tamara Hendrickson (Johns Hopkins)
"Dissecting the Evolution of Aminoacyl-tRNA Biosynthesis" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:10 pm | Poster Talk I: Shelli McAlpine (San Diego State)
"Novel antibiotics: Macrocyclic Peptides Designed to Trap Holliday Junctions" |
| 12:10 pm - 12:25 pm | Poster Talk II: Anna Mapp (U. Michigan-Ann Arbor)
"Defining a Minimal Small Molecule Transcriptional Activation Domain" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | NUCLEIC ACIDS |
| Discussion Leader: Scott Silverman (U. Illinois- Urbana-Champaign) |
| 7:30 pm - 8:00 pm | Sheila David (U. Utah)
"Damage Control: Recognition and Repair of OG:A Mismatches of the Adenine Glycosylase MutY" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Shana Kelley (Boston College)
"Biomolecular Sabotage: Amino Acid Promoted DNA Damage" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Myron Goodman (U. Southern California)
"Human and Bacterial Hyper-Mutation" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CATALYSIS |
| Discussion Leader: Paul Hergenrother (U. Illinois- Urbana-Champaign) |
| 9:00 am - 9:30 am | Scott Miller (Boston College)
"An Approach to Asymmetric Synthesis Based on 'Biomimetic' Catalysis" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Michael Marletta (U.C. Berkeley)
"Heme Protein Gas Sensors: Controlling Enzymes and More" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:35 am - 11:05 am | JoAnne Stubbe (MIT)
"Ribonucleotide Reductases: Radical Inititation over 35 Angstroms by Long Range Proton Coupled Electron Transfer" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:45 am | David Collum (Cornell)
"Structure-Reactivity Relationships in Organolithium Chemistry: Applications in Medicinal and Process Chemistry" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:10 pm | Poster Talk III: Mary Cloninger (Montana State)
"Using a Dendrimer as an Artificial Proteinase" |
| 12:10 pm - 12:25 pm | Poster Talk IV: Nikki Pohl (Iowa State)
"Glycocode Infidelities" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | GENOMICS AND PROTEOMICS |
| Discussion Leader: Girija Krishnamurthy (Wyeth) |
| 7:30 pm - 8:00 pm | Ben Cravatt (Scripps)
"Chemical Strategies for Activity-Based Proteomics" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Tom Kodadek (U.T. Southwestern)
"New Chemical Tools for Proteomics Research" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Anastasia Khvorova (Dharmacon)
"Mechanistic and Structural Basis Behind siRNA Potency, Specificity and Toxicity" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | SIGNALING AND HORMONES |
| Discussion Leader: Helen Blackwell (U. Wisconsin-Madison) |
| 9:00 am - 9:30 am | Tom Scanlan (UCSF)
"The Chemistry and Pharmacology of Thyroid Hormone Action" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Dewey McCafferty (Penn)
"Chemical Biology of Bacterial Virulence and Colonization" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:35 am - 11:05 am | Laura Kiessling (U. Wisconsin-Madison)
"Tuning Cellular Responses with Synthetic Ligands" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:45 am | John Kuriyan (U.C. Berkeley)
"Structural Analysis of Allosteric Control in the Ras Activator SOS" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:10 pm | Poster Talk V: Pam England (UCSF)
"Photochemically Knocking Out Glutamate Receptors In Vivo" |
| 12:10 pm - 12:25 pm | Poster Talk VI: Simon Friedman (U. Missouri, Kansas CIty)
"Light Activated RNA Interference" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | DRUG DISCOVERY AND DESIGN |
| Discussion Leader: Leslie Sloan (Lilly) |
| 7:30 pm - 8:00 pm | Harren Jhoti (Astex)
"Fragment-Based Drug Discovery Using High-Throughput Crystallography" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Philip Hajduk (Abbott)
"Mining NMR-based Screening Data: Privileged Structures and Druggability Indices" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Brian Shoichet (UCSF)
"Promiscuous Aggregation (or how I learned to stop worrying and love my artifacts)" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ENGINEERING AND DESIGN |
| Discussion Leader: Giovanna Ghirlanda (Arizona State) |
| 9:00 am - 9:30 am | Michael Hecht (Princeton)
"De Novo Proteins from Designed Combinatorial Libraries" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Ron Raines (U. Wisconsin-Madison)
"Ribonucleases as Chemotherapeutics" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:35 am - 11:05 am | Jeff Kelly (Scripps)
"Therapeutic Approaches to Protein Folding Diseases" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:45 am | Andrew Griffiths (MRC Cambridge)
"Directed Evolution Using In Vitro Compartmentalisation" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:10 pm | Poster Talk VII: Alan Kennan (Colorado State)
"Specific Assembly of Trimeric Coiled-Coils by Core Residue Steric Matching" |
| 12:10 pm - 12:30 pm | Business Meeting (Discussion, Evaluations, Election of 2006 Chairs) |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CHEMICAL BIOLOGY- LESSONS FROM NATURE |
| Discussion Leader: Mark Distefano (U. Minnesota) |
| 7:30 pm - 8:00 pm | Paul Wentworth (Scripps)
"The Janus Faces of Antibody-Catalyzed Water Oxidation - From Bacterial Destruction to Atherosclerosis" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Chris Walsh (Harvard)
"Modular Assembly of Natural Product Antibiotic Scaffolds" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Jon Clardy (Harvard)
"DNA-based Approaches to Natural Products" |
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
