Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Diversity of Chemistry in Nature |
| Discussion Leader: Michael Burkart (University of California, San Diego, USA) |
7:40 pm - 8:05 pm | Michael Fischbach (University of California, San Francisco, USA) "Small Molecules from the Human Microbiota" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Amy Wright (Florida Atlantic University, USA) "Exploring Marine Biodiversity for Potential Therapeutics" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Craig Townsend (Johns Hopkins University, USA) "Carbapenems: Biosynthesis, Pathway Engineering and Lessons from Tuberculosis" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Applications of Bioorthogonal Chemistry |
| Discussion Leader: Kabirul Islam (University of Pittsburgh, USA) |
9:00 am - 9:30 am | Joseph Fox (University of Delaware, USA) "Interfacial Bioorthogonal Chemistry: Discovery, Development, and Applications" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Kate Carroll (The Scripps Research Institute, USA) "Cysteine-Mediated Redox Signaling: Chemical Tools for Biological Discovery and Beyond" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | Thomas Sakmar (The Rockefeller University, USA) "Bioorthogonal Labeling of Engineered Membrane Proteins to Enable Single Molecule Imaging" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Selected from Poster Abstracts: Jennifer Heemstra (University of Utah, USA) "Nucleic Acids for Biosensing, Bioimaging, and Drug Delivery" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Selected from Poster Abstracts: Zhen Huang (Pfizer Worldwide Research and Development, USA) "Profiling Adduct Stability of Covalent Serine Hydrolase Inhibitors in Cells" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Selected from Poster Abstracts: Yimon Aye (Cornell University / Weill Cornell Medicine, USA) "Targeting Gain-of-Function Redox Events that Safeguard Metazoan Health and Survival" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Illuminating Biology with Imaging |
| Discussion Leader: Timothy Dore (New York University Abu Dhabi, United Arab Emirates) |
7:30 pm - 8:00 pm | Alice Ting (Massachusetts Institute of Technology, USA) "Spatially-Resolved Proteomic Mapping of Living Cells" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Luke Lavis (Janelia Research Campus, Howard Hughes Medical Institute, USA) "Building Brighter Fluorophores for Cellular Imaging" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Marcel Bruchez (Carnegie Mellon University, USA) "The Fluorogen Switch: Rational Design of Fluorogenic Sensors and Optogenetic Tools" |
9:20 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Bio-Inspired Synthesis |
| Discussion Leader: Daniel Appella (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA) |
9:00 am - 9:30 am | Jennifer Cochran (Stanford University, USA) "Engineered Peptide-Drug Conjugates for Tumor Targeting Applications" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Eric Schmidt (University of Utah, USA) "The Posttranslational Modification Toolkit for Total Synthesis" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:10 am | Helma Wennemers (ETH Zurich, Switzerland) "Bioinspired Chemistry with Proline-Rich Peptides" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Michael Jewett (Northwestern University, USA) "Repurposing Ribosomes for Synthetic Biology" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Selected from Poster Abstracts: Kristen DeMeester (University of Delaware, USA) "Bioorthogonal Labeling
on the Carbohydrate Backbone of E. coli Peptidoglycan" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Selected from Poster Abstracts: Sarah Wallrodt (University of Konstanz, Germany) "NAD+ Analogs for Cellular Imaging of Poly(ADP-ribos)ylation" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Glycans in Health and Biology |
| Discussion Leader: Lara Mahal (New York University, USA) |
7:30 pm - 8:00 pm | David Vocadlo (Simon Fraser University, Canada) "New Chemical Biology Tools for Studying Glycoconjugates In Vivo" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Pauline Rudd (National Institute for Bioprocessing Research and Training (NIBRT), Ireland) "Glycoscience and the Systems Biology of Disease" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | James Paulson (The Scripps Research Institute, USA) "Modulating Immune Responses with Siglec Targeted Nanoparticles" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Chemoproteomics in Therapeutic Applications |
| Discussion Leader: Brent Martin (University of Michigan, USA) |
9:00 am - 9:30 am | Daniel Nomura (University of California, Berkeley, USA) "Mapping Metabolic Drivers of Disease Using Chemoproteomic and Metabolomic Platforms" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Markus Schirle (Novartis Institutes for Biomedical Research, USA) "Chemoproteomics-Based Approaches for Target Deconvolution of Bioactive Compounds" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | Stephan Sieber (Technical University of Munich, Germany) "Chemical Tools to Manipulate Bacterial Pathogenesis" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Selected from Poster Abstracts: Michael Cohen (Oregon Health and Science University, USA) "A Chemical Genetics Approach for Identifying Family-Member Specific Targets of ARTDs" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Selected from Poster Abstracts: Keriann Backus (The Scripps Research Institute, USA) "Proteome-Wide Covalent Ligand Discovery in Native Biological Systems" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Selected from Poster Abstracts: Amit Choudhary (Broad Institute of MIT and Harvard / Harvard Medical School, USA) "Multidimensional Chemogenic Control of CRISPR-Cas9 in Cells and Organisms" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Drug Discovery and Therapeutics |
| Discussion Leader: David Rabuka (Catalent Pharma Solutions, USA) |
7:30 pm - 8:00 pm | Adam Johnson (Genentech, USA) "Battling BTK Mutants" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Markus Bantscheff (Cellzome GmbH, Germany) "Comprehensive Drug Target Profiling Using Orthogonal Chemoproteomics Technologies" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | David Gray (Pfizer, Inc, USA) "Probing Molecular Features Which Contribute to Agonism and Signaling Bias at the Dopamine D1 Receptor" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Approaches to Tame Intractable Targets |
| Discussion Leader: Amanda Hargrove (Duke University, USA) |
9:00 am - 9:30 am | Yueming Li (Memorial Sloan Kettering Cancer Center, USA) "Regulation of Gamma-Secretase: From Small Molecules to Modulatory Subunits" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Robert Garbaccio (Merck and Co., Inc., USA) "An Antibody-Drug Conjugate Approach to Tissue-Selective Glucocorticoids" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | M.G. Finn (Georgia Institute of Technology, USA) "Virus-Like Particle Based Delivery of Biological Function" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Selected from Poster Abstracts: Ryan Mehl (Oregon State University, USA) "Ideal Bioorthogonal Ligations with Genetic Code Expansion" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Selected from Poster Abstracts: John Schneekloth (National Cancer Institute, NIH, USA) "Targeting Structurally and Functionally Diverse RNAs with Druglike Small Molecules" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Selected from Poster Abstracts: Henning Stockmann (AbbVie Inc., USA) "Glycan-Mediated Click Chemistry for Drug-Target Identification" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Advances in Chemical Biology |
| Discussion Leader: John Koh (University of Delaware, USA) |
7:30 pm - 8:00 pm | Paola Castaldi (AstraZeneca, USA) "Small Molecules Driven Chemical Biology and Target Deconvolution Strategies" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | John Pezacki (University of Ottawa, Canada) "Being SMART and Staying Active: Uncovering the Roles of RNAs and Enzymes in Host-Virus Interactions" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Gabriela Chiosis (Memorial Sloan Kettering Cancer Center, USA) "Chemical Biology Approach to the Chaperome - From Mechanisms to Drugs and Diagnostics" |
9:20 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |