Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Intra and Extracellular Biomolecular Recognition
7:40 pm - 8:05 pm
"Discovering and Modulating How Cell Surfaceomes Change in Cancer"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Chemical Approaches to Dissect the Diverse Functions of Proteins in the AAA+ Superfamily"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Protein Disorder and Dynamics
9:00 am - 9:30 am
"Analyses of Folding and Binding of Intrinsically Disordered Proteins"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"From Fuzzy to Function: The New Frontier of Protein-Protein Interactions"
10:10 am - 10:20 am
Discussion
10:20 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
"Ligand-Controlled Conformational Plasticity: Lessons Learned from Natural and Artificial Control of Protein-Protein Interactions"
11:10 am - 11:20 am
Discussion
11:20 am - 11:50 am
"Engineered Protein Switches for Studying Intracellular Signaling Dynamics"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Development of Novel Chemical Biology Tools to Combat Autoimmunity"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Developing Optical Chemical Probes for Imaging Proteolytic Signatures"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Translational Chemical Biology
7:30 pm - 8:00 pm
"Harnessing the Immune System to Fight Cancer: What Will Be the Role of Small Molecule Drug Discovery"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Targeting the Tumor Microenvironment with Antibody Therapeutics"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"A Chemist's Foray into Translational Research - From Stem Cells to Neglected Disease"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Challenges in Nucleic Acids Recognition and Therapeutics
9:00 am - 9:30 am
"Fluorescent DNA Nanodevices to Quantitate Protein Activity in Living Systems"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Cosmic-Seq Based Surprises on How Synthetic Genome Readers Engage Chromatinized Genomes in Live Human Stem Cells"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Process Development in Antisense Oligonucleotides"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Social Amoebae: A Rich Source of Natural Products"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Olfactory Receptor-Based Sensors to Accelerate the Engineering of Chemical-Producing Microbes"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Dithiolopyrrolones as Antibiotics and Organocatalysts for Protein Oxidation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Target and Organism-Based Drug Discovery
7:30 pm - 8:00 pm
"mPGES-1 Inhibitors from Start to Finish"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"In Vitro Whole Organism SAR Coupled with Rapid Advancement to In Vivo Proof-of-Concept Studies to Drive Anti-Malarial Drug Discovery"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Discovery and Development of Potent and Efficacious Pan-Mutant Androgen Receptor Antagonists"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Synthesis and Evaluation of Cell-Permeable Analogs of Trehalose to Improve the Viability of Preserved Mammalian Cells"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Understanding and Exploiting the Immune System
9:00 am - 9:30 am
"Breaking Down and Remodeling Bacterial Cell Walls"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Oligosaccharide Models to Study Regioselectivity of Chemical Activation and Protein Conjugation for Conjugate Vaccines"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Chemically Self-Assembled Nanorings: From CARS to PARS"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Near-IR Uncaging Chemistry: Discovery and Applications"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"A New Technology for Tracking Cellular Proteins at High Resolution"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Chemical Editing of the Cellular Glycocalyx to Influece Cellular Functions"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Protein Recognition and Function
7:30 pm - 8:00 pm
"Strategies for Sensing Histone Post-Translational Modifications"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Targeting Protein-Protein Interactions in the Molecular Chaperone Network"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Rational Redesign of the Collagen Triple Helix Interface"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"C-H/Ï€ and S-H/Ï€ Interactions in Biomolecular Structure, Assembly, and Engineering"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Labeling, Folding and Degrading Proteins
9:00 am - 9:30 am
"Proteolysis-Targeting Chimera (PROTACs) as Potent and Selective Degraders of Pathological Proteins"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Protein Folding: Non-Specific Interactions Can Promote Highly Specific Chain Organization"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Diazo Compounds: Versatile Tools for Chemical Biology"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Triazabutadienes as Probes for the Biochemical Environment"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Modelling Protein Post-Translational Modification in Eukaryotes Using Universal Genetic Code Expansion Systems"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Discovery of Functional Ligands from Genetically-Encoded Chemically-Modified Peptide Libraries"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Recent Advances in Chemical Biology
7:30 pm - 8:00 pm
"One-Pot Synthesis and Screening of Pseudo-Natural Peptides and Products"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Using Industrial Biotechnology to Make Spider Silk and Other Protein-Based Fibers"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Seeing and Engineering Inside Cells"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure