Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Covalent Inhibitors as Drugs
7:40 pm - 8:05 pm
"New Pharmacological Approaches to Kinase Inhibitor Discovery: Degradation, Allostery and Covalence"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Applying Chemical Biology Probes for the EGFRT790M Covalent Inhibitor Program"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Chemical Approaches to Probe Signaling by Dynamic Proteome Lipidation"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Selective Inhibition of Translation with Small Molecules"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Inhibition of Monoacylglycerol Lipase for the Treatment of Neurological Disorders"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chromatin Modifying Enzymes
9:00 am - 9:30 am
"Targeting Epigenomic Complexes"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Targeting Reversible Lys Modifications with Designed Small Molecules"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Regulation and Small Molecule Inhibition of Chromatin Demethylation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"An Expanded Landscape of Acetylation in Signaling from Chemoproteomics"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Fluorinated Proteins as Enabling Tools for Small Molecule Discovery in Epigenetics"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Protein and Small Molecule Engineering Towards a Programmable Chromatin Landscape"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Liganding Undruggable Targets
7:30 pm - 8:00 pm
"Site-Directed Screening: Harnessing Cysteines to Modulate Challenging Targets"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Expanding the Druggable Proteome Through Cereblon-Mediated Protein Degradation"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"PROTACs and Induced Protein Degradation: The 17-Year Old Overnight Phenomenon"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:30 am
"Using Genome-Wide Mutant Fitness Profiles to Decipher Compound Mechanism"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Leader Peptide Guided Natural Product Biosynthesis"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Harnessing the Chemistry of Alkaloid-Producing Plants"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Capturing Transient Interactions of Proteins Involved in Natural Product Biosynthesis"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Regulated Expression of the (Non-)Annotated Proteome"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Non-Traditional Role of Lipids in Programmed Cell Death"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chemical Biology in Drug Discovery
7:30 pm - 8:00 pm
"New Approaches to the Discovery and Delivery of Agents Targeting RNA-Mediated Disease"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Chemistry Meets Omics: Understanding How Drugs Work"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Chemical Biology Approach for Small Molecule Inhibitor Mechanism of Action Studies in Living Cells"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"PhABits Shine Lght on Fragment-Protein Binding"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Imaging and Optochemical Control
9:00 am - 9:30 am
"Illuminating the Biochemical Activity Architecture of the Cell"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Optical Control of GPCRs and Kinases"
10:10 am - 10:20 am
Discussion
10:20 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
"Optical Control of Protein Function in Cells and Animals"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Harnessing Nucleic Acid Molecular Recognition for Fluorescence-Based Biomolecular Imaging"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Biocatalysis: Harnessing the Power of Nature's Tools to Build Complex Molecules"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Development of Short Peptoids as Antifungal Agents Against C. neoformans "
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Small Molecule Cleavage of a Toxic RNA Repeat"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Modulating Protein Function
7:30 pm - 8:00 pm
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Pseudo Natural Products for Phenotypic Small Molecule Discovery"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Discovery and Engineering Plant Chemistry"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Targeting RNA with Small Molecules
9:00 am - 9:30 am
"Sequence-Based Design of Small Molecules Targeting RNA"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Discovering the Pervasive Roles for Structure in ncRNA and mRNA Function"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"RNA-Targeted Small Molecules: A Problem in Drug Discovery"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Deciphering Patterns in Selective Small Molecule: RNA Interactions"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Targeting Structurally and Functionally Diverse RNAs with Druglike Small Molecules"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Selective Small Molecule Inhibition of an RNA Structural Element"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Chemical Tools to Unlock Biology
7:30 pm - 8:00 pm
"A Twist in the Tail? Precision Electrophile Sensing Guides Isoform-Selective Covalent Ligand Evolution"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Riboswitching on the Light: Illuminating the Single-Cell Biology of Bacterial Signals"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Inositol Pyrophosphate Signaling Revealed with Chemical Tools"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure