Sunday 
 
 
2:00 pm - 9:00 pm 
	
Arrival and Check-in
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 7:40 pm 
	
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
 
 
						
7:40 pm - 9:30 pm 
	
 
 
						
7:40 pm - 8:10 pm 
	
"Common Pitfalls in Preclinical Cancer Target Validation" 
 
 
 
						
8:10 pm - 8:20 pm 
	
Discussion
 
 
						
8:20 pm - 8:40 pm 
	
"Harnessing the Paracrine-cGAMP-STING Pathway for the Treatment of Cancer and Autoimmunity" 
 
 
 
						
8:40 pm - 8:50 pm 
	
Discussion
 
 
						
8:50 pm - 9:05 pm 
	
"Induced Proximity to Control Protein Modifications" 
 
 
 
						
9:05 pm - 9:10 pm 
	
Discussion
 
 
						
9:10 pm - 9:30 pm 
	
General Discussion
 
 
						
	Monday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
AI, Evolution and Systems Chemical Biology 
 
 
 
						
9:00 am - 9:20 am 
	
"Proteomics Across Deep Evolutionary Time to Decode Human Genetics" 
 
 
 
						
9:20 am - 9:30 am 
	
Discussion
 
 
						
9:30 am - 9:50 am 
	
"Expansion of the Ligandable Proteome Through AI-Driven Proteome-Wide Reactive Fragment Screening" 
 
 
 
						
9:50 am - 10:00 am 
	
Discussion
 
 
						
10:00 am - 10:30 am 
	
Coffee Break
 
 
						
10:30 am - 10:50 am 
	
"Programmable Biosynthesis of New-to-Nature Small Molecules" 
 
 
 
						
10:50 am - 11:00 am 
	
Discussion
 
 
						
11:00 am - 11:20 am 
	
"Identification of Protein Misfolding Inhibitors by Directed Evolution" 
 
 
 
						
11:20 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 11:50 am 
	
"Chemical Proteomic Approaches to Study Post-Translational and Pharmacological Landscapes of Immune Dysfunction" 
 
 
 
						
11:50 am - 12:00 pm 
	
Discussion
 
 
						
12:00 pm - 12:10 pm 
	
"Regulation of Ribosome Biogenesis by a Disordered Nucleolar Microprotein" 
 
 
 
						
12:10 pm - 12:15 pm 
	
Discussion
 
 
						
12:15 pm - 12:30 pm 
	
Poster Previews
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
 
 
						
7:30 pm - 7:50 pm 
	
"Tripping Hypae and Remodeling Cell Walls with Chemical Glycobiology" 
 
 
 
						
7:50 pm - 8:00 pm 
	
Discussion
 
 
						
8:00 pm - 8:20 pm 
	
"30 Years of Covalent Probes Targeting Hydrolases: From 'Tools' to Imaging Agents" 
 
 
 
						
8:20 pm - 8:30 pm 
	
Discussion
 
 
						
8:30 pm - 8:50 pm 
	
"State-Dependent Ligand and Target Discovery in Cells" 
 
 
 
						
8:50 pm - 9:10 pm 
	
Discussion
 
 
						
9:10 pm - 9:30 pm 
	
General Discussion
 
 
						
	Tuesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
8:30 am - 9:00 am 
	
Group Photo
 
 
						
9:00 am - 12:30 pm 
	
NGS-Based Chemical Biology 
 
 
 
						
9:00 am - 9:20 am 
	
"Decoding Inhibitor-Induced Supercharging of Native Protein Turnover" 
 
 
 
						
9:20 am - 9:30 am 
	
Discussion
 
 
						
9:30 am - 9:50 am 
	
"Sequence Space Exploration in Phosphotyrosine Signaling Proteins" 
 
 
 
						
9:50 am - 10:00 am 
	
Discussion
 
 
						
10:00 am - 10:30 am 
	
Coffee Break
 
 
						
10:30 am - 10:50 am 
	
"A High-Throughput Synthetic Biology and Chemistry Platform for Building Small Molecule Correctors" 
 
 
 
						
10:50 am - 11:00 am 
	
Discussion
 
 
						
11:00 am - 11:20 am 
	
"Parallel Methods for Studying Signaling Enzyme Function and Druggability" 
 
 
 
						
11:20 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 11:50 am 
	
"Intracellular Protein Editing" 
 
 
 
						
11:50 am - 12:00 pm 
	
Discussion
 
 
						
12:00 pm - 12:10 pm 
	
"A Comprehensive Census of Covalent Warhead Reactivity with Nucleobases, Nucleotides, and RNA" 
 
 
 
						
12:10 pm - 12:15 pm 
	
Discussion
 
 
						
12:15 pm - 12:30 pm 
	
Poster Previews
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Chemical Control of Nucleic Acid Function 
 
 
 
						
7:30 pm - 7:50 pm 
	
"Control of RNA Demethylases by Vitamin C" 
 
 
 
						
7:50 pm - 7:55 pm 
	
Discussion
 
 
						
7:55 pm - 8:15 pm 
	
"Cell Surface glycoRNA Biology" 
 
 
 
						
8:15 pm - 8:20 pm 
	
Discussion
 
 
						
8:20 pm - 8:40 pm 
	
"Enabling Technologies for Revealing Druggable Paths in RNA Biology" 
 
 
 
						
8:40 pm - 8:45 pm 
	
Discussion
 
 
						
8:45 pm - 9:05 pm 
	
"Circular RNAs in Health & Disease" 
 
 
 
						
9:05 pm - 9:10 pm 
	
Discussion
 
 
						
9:10 pm - 9:30 pm 
	
General Discussion
 
 
						
	Wednesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Imaging and Molecular Detection 
 
 
 
						
9:00 am - 9:20 am 
	
"Visualizing Living Systems with Shortwave Infrared Light" 
 
 
 
						
9:20 am - 9:30 am 
	
Discussion
 
 
						
9:30 am - 9:50 am 
	
"Imaging Tools and Technologies Inspired by Nature’s Light-Emitting Chemistry" 
 
 
 
						
9:50 am - 10:00 am 
	
Discussion
 
 
						
10:00 am - 10:30 am 
	
Coffee Break
 
 
						
10:30 am - 10:50 am 
	
"New Enzyme Chemistry to Decipher Post-Translational Modification Function" 
 
 
 
						
10:50 am - 11:00 am 
	
Discussion
 
 
						
11:00 am - 11:20 am 
	
"Imaging and Engineering the Central Dogma" 
 
 
 
						
11:20 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 11:50 am 
	
"Engineering Synthetic Interfaces for Noninvasive Control and Monitoring of the Brain" 
 
 
 
						
11:50 am - 12:00 pm 
	
Discussion
 
 
						
12:00 pm - 12:10 pm 
	
"Mesoscale Proximity Labeling at Chromatin to Study Small Molecule Mechanism of Action" 
 
 
 
						
12:10 pm - 12:15 pm 
	
Discussion
 
 
						
12:15 pm - 12:30 pm 
	
Poster Previews
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
 
 
						
7:30 pm - 7:50 pm 
	
"Illuminating Acetyl-CoA in Live Cells" 
 
 
 
						
7:50 pm - 8:00 pm 
	
Discussion
 
 
						
8:00 pm - 8:10 pm 
	
"Chemistry-Enabled Biological Discovery in Metabolism and Aging" 
 
 
 
						
8:10 pm - 8:15 pm 
	
Discussion
 
 
						
8:15 pm - 8:25 pm 
	
"Novel Approaches to Modulating Mitochondrial Metabolism" 
 
 
 
						
8:25 pm - 8:30 pm 
	
Discussion
 
 
						
8:30 pm - 8:50 pm 
	
"Biocatalysis and Complex Molecule Synthesis" 
 
 
 
						
8:50 pm - 9:10 pm 
	
Discussion
 
 
						
9:10 pm - 9:30 pm 
	
General Discussion
 
 
						
	Thursday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
8:30 am - 9:00 am 
	
Business Meeting 
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s) 
 
 
						
9:00 am - 12:30 pm 
	
Translational Chemical Biology 
 
 
 
						
9:00 am - 9:20 am 
	
"Expanding the Alphabet and Topology of Synthetic mRNAs for Therapeutics" 
 
 
 
						
9:20 am - 9:30 am 
	
Discussion
 
 
						
9:30 am - 9:50 am 
	
"Chemical Degradation of N-Myc for the Treatment of Pediatric Neuroblastoma" 
 
 
 
						
9:50 am - 10:00 am 
	
Discussion
 
 
						
10:00 am - 10:30 am 
	
Coffee Break
 
 
						
10:30 am - 10:50 am 
	
"Chemoproteomic Strategies for Studying (de)ISGylation Pathways" 
 
 
 
						
10:50 am - 11:00 am 
	
Discussion
 
 
						
11:00 am - 11:20 am 
	
"Small Molecule Inhibitors of Aberrant Chromatin Association in AML" 
 
 
 
						
11:20 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 11:50 am 
	
"Targeting Histone Lysine Acetylation in Cancer" 
 
 
 
						
11:50 am - 12:00 pm 
	
Discussion
 
 
						
12:00 pm - 12:10 pm 
	
"A Novel and High Throughput Chemoproteomic Platform to Identify Druggable Pockets and Chemical Probes for Classically Intractable Proteins" 
 
 
 
						
12:10 pm - 12:15 pm 
	
Discussion
 
 
						
12:15 pm - 12:25 pm 
	
"Discovery of RMC-5127, an Oral, RAS(ON) G12V-Selective, Noncovalent, Tri-Complex Inhibitor" 
 
 
 
						
12:25 pm - 12:30 pm 
	
Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Proximity-Induced Modalities 
 
 
 
						
7:30 pm - 7:50 pm 
	
"Rewriting Protein Modifications in Cells" 
 
 
 
						
7:50 pm - 8:00 pm 
	
Discussion
 
 
						
8:00 pm - 8:20 pm 
	
"Reimagining Druggability Using Chemoproteomic Platforms" 
 
 
 
						
8:20 pm - 8:30 pm 
	
Discussion
 
 
						
8:30 pm - 9:00 pm 
	
"Modularity in Therapeutic Design" 
 
 
 
						
9:00 pm - 9:10 pm 
	
Discussion
 
 
						
9:10 pm - 9:30 pm 
	
General Discussion
 
 
						
	Friday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am 
	
Departure