Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Developing Chemical Strategies for Perturbing Protein Function
7:40 pm - 8:05 pm
"New Molecules From Nature’s Most Sophisticated Catalyst"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Reshaping Protein Interactions with Chemical and Genetic Approaches"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Activity-Based Protein Profiling: Target and Ligand Discovery on a Global Scale"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Next-Generation Therapeutic Modalities
9:00 am - 9:25 am
"Exploration of Lysosomal Protein Degradability Enables Fully Endogenous MrTAC Degraders"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Eliminating “Undruggable” from the Drug Hunter Vocabulary"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Rewiring Chromatin-Regulated Processes with Proximity Pharmacology"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Molecules in Motion: Leveraging Structure and Dynamics Toward Precision Chemical Control of RNA Function"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Chemical Tools to Detect, Discover, and Disrupt Sugars and Sugar-Processing Enzymes in Bacteria"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
"DNA Encoded Libraries in the Hunt for Molecular Glues"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Developing Modulators for Protein-Protein and Protein-DNA Interactions
7:30 pm - 7:55 pm
"Molecular Glues in Signaling and Therapy"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Chemistry to Impact Pediatric Cancers"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Probing and Targeting LRRK2 with Small Molecules"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Sampling Chemical Space for Challenging Targets
9:00 am - 9:25 am
"Spiroligomers: Abiotic, Functionalized, Stereochemically-Rich, Fused-Ring Macromolecules as Therapeutics and Molecular Recognition Elements for Diagnostics"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"De Novo Discovery of Pseudo-Natural Peptides and Products"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Harnessing DNA-Encoded Libraries for Pooled Screening: Advancing Small Molecule and Oligonucleotide Binder Discovery"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Transparent Trillion-Scale Docking with ChemSTEP"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Targeting the SARS-CoV-2 Main Protease for Drug Discovery Reveals Unique Chemistry for both Enzyme Function Regulation and Covalent Drug Discovery"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
"Advances in Small-Molecule Modulation of RNA Function"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Generative AI in Small Molecule Discovery
7:30 pm - 7:55 pm
"Generative AI in Drug Discovery: Revolution, Evolution or Complete Nonsense?"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Successful Computational Hit-Finding Strategies From CACHE Challenges: Active Learning, Fragment Growing and More"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Applications of High-Throughput Chemistry in Machine Learning"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Small Molecules and Omics-Driven Approaches
9:00 am - 9:25 am
"Chemical Proteomics-Enabled Protein Function Discovery and Targeted Modulation"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Defining Functional and Therapeutically Relevant Proteoforms with Chemoproteomics"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Targeted Protein Control at the Cell Surface"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Leveraging Proteomics in Targeted Protein Drug Discovery"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Covalent Chemistry and Bioorthogonal Chemical Reactions Enabling Biological Insights
7:30 pm - 7:55 pm
"Chemical Hijacking of Cancer and Immune Signaling"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Chemoproteomic Discovery of Covalent, Allosteric Inhibitors of SHP2 Targeting a Novel Site"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Adventures in Covalent Drug Discovery: Balancing Potency and Selectivity"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
"Building Tunable Chemistry to Probe Living Systems"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Chemical Biology Driving Therapeutics Across Disease Areas
9:00 am - 9:20 am
General Discussion
9:20 am - 9:45 am
"In vivo Chemical Biology in a Vertebrate"
9:45 am - 9:50 am
Discussion
9:50 am - 10:15 am
"GPCR-Based Sensors in Yeast to Accelerate Drug Discovery"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Leveraging DNA-Encoded Libraries to Discover PGK2 Chemical Probes for Contraception"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Investing in Chemistry to Guide Target Validation
7:30 pm - 7:55 pm
"Protein Editing: Getting at the Center of Things"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Application of High-Throughput Degrader Chemistry to Enable Clinically Differentiated Therapeutics"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Rewiring Oncogenic Circuits to Programmed Cell Death"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure