Conference Description
The skeleton is an organ composed of many tissues and with a variety of fundamental and vital functions. In the last few years, it has become increasingly clear that the metabolic pathways and local environments have a crucial role in the biology of the skeleton. Those new developments are opening exciting avenues for research. They may also lead to novel treatments of devastating conditions such as osteoporosis, osteopetrosis, bone cancer, and genetic disorders of the skeleton, as well as systemic pathologies, including the dysregulation of bioenergetic metabolism. The theme of our conference is “Metabolism and local environments in development, disease and regeneration of the skeleton”. Significant progress in the understanding of local communication among cells that form bone and maintain its integrity during the lifespan of the organism will be presented. Likewise, the interactions of bone cells with the other tissues constituting the skeleton, namely blood vessels, hematopoietic marrow, bone marrow fat, bone marrow stroma, and tendons will be examined. Lastly, the molecular and cellular mechanisms within the skeleton that integrate local interactions, bioenergetics metabolism and biomechanical forces will be discussed. The overall goal of the conference is to encourage the pursuit of new research directions and novel therapeutic approaches, as well as foster highly productive collaborations among top laboratories in the field.
The topics, speakers, and discussion leaders for the conference sessions are displayed below. The conference chair is currently developing their detailed program, which will include the complete meeting schedule, as well as the talk titles for all speakers. The detailed program will be available by September 16, 2021. Please check back for updates.
Metabolism and Bone Cells
Discussion Leaders
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Fanxin Long (Children's Hospital of Philadelphia, USA)
Speakers
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Brendan Lee (Baylor College of Medicine, USA)
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Geert Carmeliet (KU Leuven, Belgium)
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Gerard Karsenty (Columbia University , USA)
Development of Skeleton and Teeth
Discussion Leaders
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Karen Lyons (University of California, Los Angeles, USA)
Speakers
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Andrei Chagin (Karolinska Institute, Sweden)
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Joel Boerckel (University of Pennsylvania, USA)
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Véronique Lefebvre (Children's Hospital of Philadelphia, USA)
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Wanida Ono (University of Michigan School of Dentistry, USA)
Origin and Fate of Bone Cells
Discussion Leaders
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Deneen Wellik (University of Wisconsin-Madison, USA)
Speakers
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Vicki Rosen (Harvard School of Dental Medicine, USA)
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Maria Almeida (University of Arkansas for Medical Sciences, USA)
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Sarah Dallas (University of Missouri-Kansas City, USA)
Cross Talks Among Hematopoietic, Endothelial, and Bone Cells
Discussion Leaders
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Henry Kronenberg (Massachusetts General Hospital, USA)
Speakers
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Laura Calvi (University of Rochester, USA)
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Anjali Kusumbe (University of Oxford, United Kingdom)
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Matthew Greenblatt (Cornell University, USA)
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Michelle McDonald (Garvan Institute of Medical Research, Australia)
Contribution of Bone Marrow Adipocytes and Stroma to Bone Homeostasis
Discussion Leaders
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Clifford Rosen (Maine Medical Center, USA)
Speakers
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Steven Teitelbaum (Washington University School of Medicine, USA)
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Ling Qin (University of Pennsylvania, USA)
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Michaela Reagan (Maine Medical Center, USA)
Tumor Microenvironment in Bone
Discussion Leaders
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Amato Giaccia (Stanford University, USA)
Speakers
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Rachelle Johnson (Vanderbilt University, USA)
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Theresa Guise (MD Anderson Cancer Center, USA)
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Peter Croucher (Garvan Institute of Medical Research, Australia)
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Stavroula Kousteni (Columbia University, USA)
Development and Biomechanics of the Bone-Tendon Unit
Discussion Leaders
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Elazar Zelzer (Weizmann Institute of Science, Israel)
Speakers
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Matthew Silva (Washington University School of Medicine, USA)
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Stavros Thomopoulos (Columbia University, USA)
Rare Bone Diseases
Discussion Leaders
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Maurizio Pacifici (Children's Hospital of Philadelphia, USA)
Speakers
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Thomas Gardella (Massachusetts General Hospital, USA)
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Laurence Legeai-Mallet (Institut Imagine, France)
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Anna Teti (Universita' dell'Aquila, Italy)
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Benjamin Levi (UTSouthwestern, USA)
Regeneration of Bone
Discussion Leaders
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Yingzi Yang (Harvard School of Dental Medicine, USA)
Speakers
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Jerome Guicheux (University of Nantes, France)
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Kurt Hankenson (University of Michigan, USA)
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Regina Brunauer (Texas A&M University, USA)
