| SATURDAY |
| 1:30 pm - 4:30 pm | Arrival and Check-in |
| 3:00 pm - 3:15 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:15 pm - 4:00 pm | Keynote Address |
| 3:15 pm - 3:45 pm | Kenneth H. Fischbeck (NINDS)
"CAG Expansion Disorders - Pathogenic insights and therapeutic approaches" |
| 3:45 pm - 4:00 pm | Discussion |
| 4:00 pm - 5:30 pm | Poster Session I |
| 5:30 pm - 7:30 pm | Molecular Mechanisms of Disease: Protein and RNA gain and loss of function |
| Discussion Leader: Beverly L. Davidson (University of Iowa) |
| 5:30 pm - 5:45 pm | Kevin N. Dietz (Massachusetts General Hospital)
"Investigating the normal function of huntingtin in Drosophila" |
| 5:45 pm - 5:50 pm | Discussion |
| 5:50 pm - 6:05 pm | Thorsten Mueller (University of Clinic Bonn)
"Phosphorylation of ATXN3 - a key event in SCA3 pathogenesis" |
| 6:05 pm - 6:10 pm | Discussion |
| 6:10 pm - 6:25 pm | Jacqueline Gire (University of California, Irvine)
"SUMO modification of huntingtin in HD pathogenesis" |
| 6:25 pm - 6:30 pm | Discussion |
| 6:30 pm - 6:45 pm | Tao Zu (University of Florida)
"Expression and post-translational modification of proteins expressed by repeat associated non-ATG translation (RAN-translation)" |
| 6:45 pm - 6:50 pm | Discussion |
| 6:50 pm - 7:05 pm | Nicholas S. Caron (McMaster University)
"Measuring Fluorescence Lifetime in Living Cells Reveals Huntingtin Exon1 Structure at Nanometer Resolution" |
| 7:05 pm - 7:10 pm | Discussion |
| 7:10 pm - 7:30 pm | Structured Discussion |
| 8:00 pm | Dinner |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Pathophysiology of Neurodegeneration |
| Discussion Leader: Austen J. Milnerwood (University of British Columbia) |
| 9:00 am - 9:15 am | Ulrike Träger (UCL Institute of Neurology)
"Innate immune dysfunction in Huntington's disease" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Ricardo Mouro Pinto (Harvard Medical School)
"Mlh1 - a genetic modifier of CAG repeat instability in HD CAG knock-in mice" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Clare M. Gladding (University of British Columbia)
"Investigating the molecular mechanisms underlying increased extrasynaptic NMDA receptor localization in a mouse model of Huntington's Disease" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Renee R. Handley (University of Auckland Centre for Brain Research)
"Identifying early gene expression changes in a transgenic ovine model of Huntington's disease" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Ryan L. Boudreau (University of Iowa)
"Improving the safety of RNAi therapy for polyQ-repeat diseases" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 11:00 am | Structured Discussion |
| 11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Career Panel: Beyond the PhD in the field of CAG Triplet Repeat Disorders |
| 1:30 pm - 1:45 pm | James Palacino (Novartis)
"Introduction to industry research in neurodegenerative disorders" |
| 1:45 pm - 1:50 pm | Discussion |
| 1:50 pm - 2:05 pm | Meredith LeMasurier (Cell Press)
"Career opportunities as a journal editor" |
| 2:05 pm - 2:10 pm | Discussion |
| 2:10 pm - 2:25 pm | Deanna Marchionini (CHDI)
"Science careers at not-for-profit organizations" |
| 2:25 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill out GRS Evaluation Forms |
| 3:00 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |
