Find a Conference

Phishing Alert - GRC SPEAKERS AND DISCUSSION LEADERS ARE BEING TARGETED BY PHISHING ATTEMPTS DESIGNED TO COLLECT PAYMENT FOR REGISTRATION OR LODGING. CLICK HERE FOR MORE DETAILS

CAG Triplet Repeat Disorders (GRS)

Gordon Research Seminar

Understanding and Treating CAG Repeat Expansion Disorders

May 24 - 25, 2025

Chairs

and

Renaissance Tuscany Il Ciocco

Via Giovanni Pascoli

Lucca (Barga), Lucca, Italy

Venue and Travel Information

Conference Description

The CAG Triplet Repeat Disorders GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

This GRS will encompass the entire spectrum of CAG repeat disorders, uniting researchers focused on Huntington’s Disease, Spinocerebellar Ataxia, Spinal and Bulbar Muscular Atrophy and Dentatorubral-pallidoluysian Atrophy. The conference will feature a keynote presentation by a leading researcher, followed by a selection of oral presentations from reviewed abstracts. Additionally, a dedicated poster session will provide a platform for attendees to present and discuss their research in a relaxed and friendly environment. Research ranging from molecular mechanisms of disease to therapeutic development will be presented and discussed. During the meeting there will be ample time for networking and opportunities to explore career options through discussion with mentors from academia and industry.

Related Meeting

This GRS will be held in conjunction with the "CAG Triplet Repeat Disorders" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:00 pm - 3:15 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm	Keynote Session: Pathology of Somatic CAG Repeat Expansion Discussion Leader:
3:15 pm - 3:45 pm	"The Pathogenic Consequences of Somatic CAG Repeat Expansion"
3:45 pm - 4:00 pm	Discussion
4:00 pm - 5:30 pm	Poster Session
5:30 pm - 7:30 pm	Mechanisms of Neurodegeneration Discussion Leader:
5:30 pm - 5:40 pm	"Distinct Molecular Patterns in R6/2 HD Mouse Brain: Insights from Spatiotemporal Transcriptomics"
5:40 pm - 5:45 pm	Discussion
5:45 pm - 5:55 pm	"Modeling Early Cellular and Molecular Features of Huntington’s Disease in Human Stem Cell-Derived Cortical Organoids"
5:55 pm - 6:00 pm	Discussion
6:00 pm - 6:10 pm	"Integrated Analysis Highlights Impairment of PGC-1 Alpha as a Mediator of SBMA Skeletal Muscle Pathology"
6:10 pm - 6:15 pm	Discussion
6:15 pm - 6:25 pm	"Global Transcriptomic Shifts in Early Stages of DRPLA Disease in a Fly Model"
6:25 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	"Huntingtin is an RNA Binding Protein and Participates in NEAT1-Mediated Paraspeckles"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 6:55 pm	"Molecular Mechanisms of Degeneration in Spinocerebellar Ataxia Type 3: Transcriptomic Insights from the Spinal Cord"
6:55 pm - 7:00 pm	Discussion
7:00 pm - 7:10 pm	"Striatal Pathology Contributes to Motor Deficits in Spinocerebellar Ataxia Type 1 (SCA1) Mice"
7:10 pm - 7:15 pm	Discussion
7:15 pm - 7:25 pm	"Aberrant Splicing in Huntington’s Disease Accompanies Disrupted TDP-43 Activity and Altered m6A RNA Modification"
7:25 pm - 7:30 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Biomarkers, Therapeutic Approaches and Epidemiology Discussion Leader:
9:00 am - 9:15 am	"CRISPR Interference-Mediated Silencing of ATXN2 to Mitigate Pathological Features in Spinocerebellar Ataxia Type 2 Patient-Derived Neurons"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	"Increased Frequency of Repeat Expansion Mutations Across Different Populations"
9:35 am - 9:40 am	Discussion
9:40 am - 9:55 am	"Extracellular Vesicles Contain Huntingtin and Present a Potential Biomarker for Huntington Disease"
9:55 am - 10:00 am	Discussion
10:00 am - 10:15 am	"Increasing CAG Repeat Length in the Huntingtin Gene is Associated with Smaller Subcortical Brain Volumes in Individuals that have Normal and Intermediate Alleles"
10:15 am - 10:20 am	Discussion
10:20 am - 10:35 am	"Exploring DNA Repair Complex Modifications in Huntington’s Disease"
10:35 am - 10:40 am	Discussion
10:40 am - 10:55 am	"Multi-Study Harmonization of Plasma Neurofilament Light Protein Levels in Huntington’s Disease"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Genetic Modifiers and Somatic CAG Repeat Expansion Discussion Leader:
1:30 pm - 1:45 pm	"In Vivo Crispr-Cas9-Mediated Knockout To Assess Somatic Instability Impact On Huntington's Disease Phenotypes And Therapeutic Implications"
1:45 pm - 1:50 pm	Discussion
1:50 pm - 2:05 pm	"Somatic Expansion and Loss of Interruption Variants in Huntington Disease: Insights from Peripheral Blood and Postmortem Brain Tissues"
2:05 pm - 2:10 pm	Discussion
2:10 pm - 2:25 pm	"The Role of PMS1 ATPase Activity in Somatic CAG Repeat Expansion"
2:25 pm - 2:30 pm	Discussion
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

Contributors

Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS143274. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conference Links

Conference History CAG Triplet Repeat Disorders

Registration Fees Additional Fee Info

Similar Gordon Research Conferences and Seminars

Contact Us

MyGRC Account
Check your application status, complete your registration, update your poster, change your rooming preference, make a bus reservation, print an invitation letter, print a receipt (which includes verification that you are presenting a poster) or print an invoice by logging into your account.

GRC Venues
Everything you need to know, to plan your trip.

FAQs
Instant answers to common questions.

Tell us how we can help

Call us and leave a detailed message at: 401-783-4011

*This voicemail is only checked once daily. Due to high volume of requests during the conference season, responses may be delayed.

You have no notifications