Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Microglia Function in the Brain
Discussion Leader: Andrea Hohmann (Indiana University, United States)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 9:00 pm
Beth Stevens (Boston Children's Hospital and Harvard Medical School, United States)
"Connecting Microglia States to Function in Development and Disease"
9:00 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Probes to Modulate and Visualize the Endocannabinoid System
Discussion Leader: Istvan Katona (Indiana University Bloomington, United States)
9:00 am - 9:30 am
Yulong Li (Peking University, China)
"Spying on Endocannabinoid Dynamics by Constructing New Genetically-Encoded GRAB Sensors"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Uwe Grether (F. Hoffmann-La Roche Ltd, Switzerland)
"Chemical Probes and Development Candidates Targeting CB2R and MAGL"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Laura Heitman (LACDR, Leiden University, The Netherlands)
"Cannabinoid Receptor Drug Discovery – Adding Kinetic Context"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
James Frank (Oregon Health & Science University, United States)
"Light-Activatable Tools to Manipulate Endocannabinoid Signaling in CNS"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Miklós Zöldi (Indiana University, United States)
"A Novel Approach for STORM Super-Resolution Imaging of the Endocannabinoid System in Ultrathin Astrocytic Processes"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Giuseppe Gangarossa (Université Paris Cité, France) and Leah Mayo (University of Calgary, Canada)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Endocannabinoid Trafficking and Signaling
Discussion Leader: Michelle Glass (University of Otago, New Zealand)
6:00 pm - 6:20 pm
Ruth Ross (University of Toronto, Canada)
"Modulation of the Endocannabinoid System in Hyperdopaminergic States: Therapeutic Opportunities and Concerns"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Elizabeth Liedhegner (University of Wisconsin Milwaukee, United States)
"Sterol Carrier Protein 2 and Modulation of Endocannabinoid Trafficking"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Jürg Gertsch (IBMM University of Bern)
"Identification of an Endocannabinoid Reuptake and Recycling Machinery"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Pal Pacher (National Institute on Alcohol Abuse and Alcoholism, NIH, United States)
"CB2R Detection in the Brain Gets a Second Look"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Session in Memory of Daniela Parolaro and Raphael Mecoulam: (Endo)cannabinoids and Neurodevelopment
Discussion Leader: Tiziana Rubino (University of Insubria, Italy)
9:00 am - 9:30 am
Yasmin Hurd (Icahn School of Medicine at Mount Sinai, United States)
"High Times for Cannabis and its Developmental Epigenetic Trajectory"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Pier Vincenzo Piazza (Aelis Farma, France)
"Signaling Specific Inhibitors of the CB1R as a New Approach for the Treatment of Cognitive Impairments"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Viviana Trezza (Dept. Science, Roma Tre University, Italy)
"Endocannabinoids and Autism Spectrum Disorder: Shedding Light on Therapeutic Potential and Mechanisms"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
Davide Dulcis (University of California San Diego, United States)
"Nicotine and THC Side by Side: A Molecular Memory of Prenatal Drug Exposure Affecting Behavior"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Synaptic Effects of (Endo)cannabinoids
Discussion Leader: Bradley Alger (University of Maryland, Baltimore, United States)
6:00 pm - 6:20 pm
Stephanie Cragg (University of Oxford, United Kingdom)
"Diverse Neuronal and Non-Neuronal Striatal Networks that Gate Dopamine Transmission"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Raffaella Tonini (Istituto Italiano di Tecnologia (IIT), Italy)
"Noradrenaline-Endocannabinoid System Interaction within the Dorsal Raphe Nucleus Microcircuit"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Barna Dudok (Baylor College of Medicine, United States)
"Endocannabinoid Signaling at Inhibitory Synapses in Behaving Animals"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Marta Navarrete (Cajal Institute, CSIC, Spain)
"The Role of Nucleus Accumbens Astrocytic Ensembles in Chronic THC Exposure-Induced Alterations of Glutamate Signaling and Behavior"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Endocannabinoids in Emotional Homeostasis
Discussion Leader: Patrizia Campolongo (Sapienza University of Rome, Italy)
9:00 am - 9:30 am
Carmen Sandi (Brain Mind Institute, EPFL, Switzerland)
"Neural Circuits and Metabolic Pathways on the Links Between Stress, Anxiety and Motivation"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Joseph Cheer (University of Maryland School of Medicine, United States)
"Mobilization of 2-AG By Midbrain Dopamine Neurons is Required for the Encoding of Predictive Warning Signals During the Avoidance of Fear"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Giovanni Marsicano (INSERM U1215, France)
"How Stress Uses Mitochondrial CB1R to Alter Cognition"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
Giuseppe Gangarossa (Université Paris Cité, France)
"Exploring New Roles of Endocannabinoids in Scaling Feeding Behaviors and Energy Homeostasis"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Beat Lutz (Leibniz Institute for Resilience Research, Germany)
"Individuality in Emotional Responses"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Endocannabinoid Signalling in Dysregulated Cell Behavior
Discussion Leader: Manuel Guzman (Complutense University of Madrid, Spain, Spain)
6:00 pm - 6:20 pm
Leila Akkari (Netherlands Cancer Institute, The Netherlands)
"Immunosuppression in the Brain Tumor Microenvironment: Macrophages at Play"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Ku-Lung Hsu (University of Texas at Austin, United States)
"Endocannabinoid Biosynthetic Enzymes: Targets for Modulating Inflammation and Pain"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Huaibin Cai (NIA/NIH, United States)
"Endocannabinoid Signaling in Dopaminergic Neurons and Parkinson's Disease"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Nephi Stella (University of Washington, United States)
"Activity-Dependent Production of 2-AG: Biological Function and Modulation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Neuroprotective Effects of (Endo)cannabinoids
Discussion Leader: Mauro Maccarrone (University of L’Aquila, Italy)
9:00 am - 9:30 am
Inge Huitinga (Netherlands Institute for Neuroscience, The Netherlands)
"The Endocannabinoid System in Relation to Multiple Sclerosis Pathology"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Emma Puighermanal (Autonomous University of Barcelona, Spain)
"Cannabidiol and its Potential Therapeutic Use in Primary Mitochondrial Diseases"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Elizabeth Thiele (Massachusetts General Hospital, United States)
"The Role of Cannabinoids in the Treatment of Epilepsy: More than Millenia in the Making"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
Alline Campos (University of Sao Paulo, Brazil)
"Design and Characterization of a New Approach for the Study of Cannabidiol Delivery in Neural Cells Using Live Imaging"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Late-Breaking Topic
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Exploiting the Endocannabinoid System in Therapy
Discussion Leader: Daniele Piomelli (University of California, Irvine, United States)
6:00 pm - 6:20 pm
Late-Breaking Topic
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Late-Breaking Topic
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Sachin Patel (Northwestern University, United States)
"2-AG Regulation of Stress Adaptation Supports the Therapeutic Potential Of MAGL Inhibition"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Matthew Hill (Hotchkiss Brain Institute, University of Calgary, Canada)
"Endocannabinoid Regulation of CRH Neurons In The PVN Governs Activation and Recovery from Stress: Therapeutic Implications"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure