| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff and the Chair, Dr. Natalia Trayanova |
| 7:40 pm - 7:50 pm | Opening remarks: Douglas Zipes |
| 7:50 pm - 9:30 pm | OXIDATIVE STRESS AND ARRHYTHMIAS I |
| Discussion Leader: Dario DiFrancesco (University of Milan) |
| 7:50 pm - 8:25 pm | Mark Anderson (University of Iowa)
"Oxidative stress and CaMKII" |
| 8:25 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:15 pm | Zhilin Qu (UCLA)
"Chaotic Afterdepolarizations and Arrhythmias Induced by Oxidative Stress" |
| 9:15 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | FIBROSIS AND ARRHYTHMOGENESIS |
| Discussion Leader: Jose Jalife (University of Michigan) |
| 9:00 am - 9:10 am | Trainee Presentation: Kathleen McDowell (Johns Hopkins University)
"Characterizing the arrhythmogenic substrate resulting from fibroblast-myocyte coupling in the infarcted heart" |
| 9:10 am - 9:15 am | Discussion |
| 9:15 am - 9:50 am | Wayne Giles (University of Calgary)
"Properties of Fibroblasts in the Heart" |
| 9:50 am - 10:10 am | Discussion |
| 10:10 am | Coffee Break / Group Photo |
| 10:40 am - 11:15 am | Stephan Rohr (University of Bern)
"Fibroblast-myocyte Interactions: Insights from Cell Culture Studies" |
| 11:15 am - 11:35 am | Discussion |
| 11:35 am - 12:10 pm | Jacques de Bakker (Interuniversity Cardiology Institute of the Netherlands)
"Fibrosis: A Clinical Perspective" |
| 12:10 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | OXIDATIVE STRESS AND ARRHYTHMIAS II |
| Discussion Leader: Glenn Fishman (NYU) |
| 5:30 pm - 6:05 pm | Brian O'Rourke (Johns Hopkins University)
"Role of Oxidative Stress in Ischemia-related Arrhythmias" |
| 6:05 pm - 6:20 pm | Discussion |
| 6:20 pm - 6:55 pm | Samuel Dudley (University of Chicago)
"Oxidative Stress in the Pathogenesis of Atrial Fibrillation" |
| 6:55 pm - 7:10 pm | Discussion |
| 7:10 pm - 7:20 pm | Trainee Presentation: Yin Hua Zhang (Oxford University)
"The role of nNOS-derived nitric oxide and NADPH oxidase in the positive inotropic response to mechanical stretch in the murine myocardium" |
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CHANNELOPATHIES: FROM GENES TO BEDSIDE |
| Discussion Leader: Yoram Rudy (Washington University at St. Louis) |
| 9:00 am - 9:10 am | Trainee Presentation: Thomas O'Hara (Washington University)
"Physiological Properties of hERG 1a/1b Heteromeric Currents and a hERG 1b-Specific Mutation Associated With Long-QT Syndrome" |
| 9:10 am - 9:15 am | Discussion |
| 9:15 am - 9:50 am | BumRak Choi (Brown University)
"Rabbit Models of LQTS" |
| 9:50 am - 10:10 am | Discussion |
| 10:10 am | Coffee Break |
| 10:40 am - 11:15 am | Steve Poelzing (University of Utah)
"Sodium Channel Mutations and Arrhythmogenesis" |
| 11:15 am - 11:35 am | Discussion |
| 11:35 am - 12:10 pm | Silvia Priori (Fondazione Salvatore Maugeri, Pavia)
"Mutations in calcium controlling proteins and arrhythmias" |
| 12:10 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | HEART FAILURE |
| Discussion Leader: Igor Efimov (Washington University St. Louis) |
| 5:30 pm - 6:05 pm | Shien-Fong Lin (Indiana University)
"Cardiac Automaticity and Heart Failure" |
| 6:05 pm - 6:20 pm | Discussion |
| 6:20 pm - 6:55 pm | Lance Wilson (Case Western Reserve)
"Heart Failure: A Clinician's Perspective" |
| 6:55 pm - 7:10 pm | Discussion |
| 7:10 pm - 7:20 pm | Trainee Presentation: Maria Storm (Case Western Reserve)
"Electrophysiological Consequences of Targeted Connexin43 Overexpression in the Failing and Normal Heart" |
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 9:10 am | Industrial Presentation: Jeremy Rice (IBM)
"Multiscale Models of Cardiac ECGs with LQT1 Channelopathies" |
| 9:10 am - 9:15 am | Discussion |
| 9:15 am - 12:30 pm | ALTERNANS AND SUCSEPTIBILITY TO ARRHYTHMIAS |
| Discussion Leader: David Rosenbaum (Case Western Reserve University) |
| 9:15 am - 9:50 am | David Christini (Weil Medical College of Cornell University)
"Heterogeneities in Alternans: Applications for Antiarrhythmia Therapy" |
| 9:50 am - 10:10 am | Discussion |
| 10:10 am | Coffee Break |
| 10:40 am - 11:15 am | David Eisner (University of Manchester)
"Alternans, Ca Waves, and Arrhythmogenesis" |
| 11:15 am - 11:35 am | Discussion |
| 11:35 am - 12:10 pm | Sanjiv Narayan (UCSD)
"Alternans: Insights from Patient Studies" |
| 12:10 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | ARRHYTHMIAS IN THE HUMAN HEART |
| Discussion Leader: Robert Gilmour (Cornell University) |
| 5:30 pm - 6:05 pm | Kumaraswamy (Nanta) Nanthakumar (University of Toronto)
"What We Learned from Optical Mapping of the Human Heart" |
| 6:05 pm - 6:20 pm | Discussion |
| 6:20 pm - 6:55 pm | Nicholas Peters (Imperial College London)
"Arrhythmias in the Human Heart: A Clinical Perspective" |
| 6:55 pm - 7:10 pm | Discussion |
| 7:10 pm - 7:20 pm | Trainee Presentation: Christina Ambrossi (Washington University)
"Virtual Histology of the Human Heart Using Optical Coherence Tomography" |
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am - 9:15 am | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 9:15 am - 12:30 pm | E-C COUPLING AND ARRHYTHMIAS |
| Discussion Leader: Guy Salama (University of Pittsburg) |
| 9:15 am - 9:50 am | Peter Backx (University of Toronto)
"Mechanistic links between transient outward K+ currents, excitation-contraction coupling and arrhythmias" |
| 9:50 am - 10:10 am | Discussion |
| 10:10 am | Coffee Break |
| 10:40 am - 11:15 am | Henk ter Keurs (University of Calgary)
"Myofibrillar Ca2+ as an Initiator of Cardiac Ca Waves" |
| 11:15 am - 11:35 am | Discussion |
| 11:35 am - 12:10 pm | Penelope Boyden (Columbia University)
"Mechanism of Abnormal Ca2+ Release and Cell-wide Wave Formation in Purkinje Cells" |
| 12:10 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 5:30 pm | Free Time |
| 5:30 pm - 7:30 pm | MECHANISMS AND MECHANISM-BASED THERAPIES FOR AF |
| Discussion Leader: Peng-Sheng Chen (Indiana University) |
| 5:30 pm - 6:05 pm | Ursula Ravens (Dresden University)
"Ca Signaling and Remodeling in AF" |
| 6:05 pm - 6:20 pm | Discussion |
| 6:20 pm - 6:55 pm | Sophie Demolombe (University of Nantes)
"AF and Aging: Any Clues from Genomics?" |
| 6:55 pm - 7:10 pm | Discussion |
| 7:10 pm - 7:30 pm | Student Poster Awards Presentation and Closing Remarks |
| 8:00 pm | Dinner |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |