| SUNDAY |
| 4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | STATE-OF-THE-ART AND COMING ATTRACTIONS IN CLINICAL ARRHYTHMIA MANAGEMENT |
| Discussion Leader: Douglas Zipes (Indiana University) |
| 7:40 pm - 8:05 pm | William Stevenson (Brigham and Women's Hospital)
"Mapping and Ablating Arrhythmias - What the Clinician Does" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:40 pm | Henry Halperin (Johns Hopkins University)
"New Imaging Modalities for Localizing Arrhythmia Substrates" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:10 pm | Natalia Trayanova (Johns Hopkins University)
"Personalized Virtual Hearts for Personalized Arrhythmia Treatment" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Vadim Fedorov (Washington University)
"Human Sinus Node Function - Insights from Optical Mapping" |
| 9:25 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | SYSTEMS BIOLOGY APPROACHES TO ARRHYTHMIA RESEARCH |
| Discussion Leader: Cynthia Carnes (Ohio State University) |
| 9:00 am - 9:25 am | Emelia Benjamin (Boston University)
"Clinical Genomics of Atrial Fibrillation" |
| 9:25 am - 9:40 am | Discussion |
| 9:40 am - 10:05 am | Jennifer van Eyk (Johns Hopkins University)
"Discovering Biomarkers of Cardiovascular Disease" |
| 10:05 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:15 am | Stanley Nattel (McGill University)
"Micro RNAs - A New Frontier in Ion Channel Regulation" |
| 11:15 am - 11:30 am | Discussion |
| 11:30 am - 11:55 am | Howard Rockman (Duke University)
"High Throughput Genetic Screening Models - The Virtues of Fly Power" |
| 11:55 am - 12:10 pm | Discussion |
| 12:10 pm - 12:20 pm | Trainee Presentation: Roos F.J. Marsman (Academic Medical Center, Amsterdam)
"Cardiac conduction slowing and increased arrhythmia inducibility in coxsackie and adenovirus receptor (CAR) haploinsufficient mice" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | WHAT MAKES ATRIA FIBRILLATE? |
| Discussion Leader: Dan Roden (Vanderbilt University) |
| 7:30 pm - 7:55 pm | Jose Jalife (University of Michigan)
"What Makes the Left Atrium So Important in Atrial Fibrillation?" |
| 7:55 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm | Xander Wehrens (Baylor School of Medicine)
"Genetic Models of Atrial Fibrillation" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:10 pm | Nipavan Chiamvimonvat (UC Davis)
"Ca-activated Potassium Channels in the Atria" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Trainee Presentation: Mark Shen (Indiana University)
"In Vivo Ambulatory Autonomic Activity and Atrial Fibrillation" |
| 9:25 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Ca CYCLING AND ARRHYTHMIAS: ALTERNANS, AFTERDEPOLARIZATIONS AND CPVT |
| Discussion Leader: Penelope Boyden (Columbia University) |
| 9:00 am - 9:25 am | Sandor Gyorke (Ohio State University)
"The Ryanodine Receptor Complex and Cardiac Arrhythmias" |
| 9:25 am - 9:45 am | Discussion |
| 9:45 am - 10:10 am | Bjorn Knollmann (Vanderbilt University)
"Novel Therapies for Ca-triggered Arrhythmias I" |
| 10:10 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:05 am - 11:30 am | S.R. Wayne Chen (University of Calgary)
"Novel Therapies for Ca-triggered Arrhythmias II" |
| 11:30 am - 11:50 am | Discussion |
| 11:50 am - 12:00 pm | Trainee Presentation: Zhen Song (Northeastern University)
"Subcellular Modeling of Ca-mediated Mechanisms of Triggered Activity" |
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:20 pm | Trainee Presentation: Alex Baher (UCLA)
"Reciprocating Bigeminy: A Ping-Pong Mechanism Underlying Bidirectional Ventricular Tachycardia" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | ARRHYTHMIAS IN DISEASED AND FAILING HEARTS |
| Discussion Leader: Mark Anderson (University of Iowa) |
| 7:30 pm - 7:55 pm | Emilia Entcheva (Stony Brook University)
"Cardiac Optogenetics" |
| 7:55 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm | Zhilin Qu (UCLA)
"Subcellular Basis of Alternans and Arrhythmias in Failing Hearts" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:10 pm | Igor Efimov (Washington University)
"Electrophysiology of the Failing Human Heart" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Trainee Presentation: Byron Roberts (Cornell University)
"Modeling the Electrophysiology of Ischemia-Reperfusion" |
| 9:25 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ION CHANNEL-INTERACTING PROTEINS AND ARRHYTHMIAS |
| Discussion Leader: Guy Salama (University of Pittsburg) |
| 9:00 am - 9:25 am | Robert S. Kass (Columbia University Medical Center)
"Disruption of Local Signaling and Cardiac Arrhythmias" |
| 9:25 am - 9:40 am | Discussion |
| 9:40 am - 10:05 am | Justus Anumonwo (University of Michigan)
"Scaffolding Proteins and Regulation of K Channels" |
| 10:05 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:15 am | Robin Shaw (UC San Francisco)
"Channeling Channels to the Cell Surface" |
| 11:15 am - 11:30 am | Discussion |
| 11:30 am - 11:55 am | Connie Bezzina (Academic Medical Center, Amsterdam)
"Discovering Genes Causing Arrhythmias" |
| 11:55 am - 12:10 pm | Discussion |
| 12:10 pm - 12:20 pm | Trainee Presentation: Priscila Sato (University of Michigan)
"Interactions between Desmosomes, Gap Junctions, and Na Channels at the Cardiac Intercalated Disk" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | FIBROSIS AND ARRHYTHMIAS |
| Discussion Leader: Gregory Morley (New York University) |
| 7:30 pm - 7:55 pm | Stefan Engelhardt (Technical University Munich)
"Micro RNAs Regulating Non-Myocardial Cells in the Heart" |
| 7:55 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm | Peter Kohl (Imperial College, London)
"Fibrosis and Myocyte-Myofibroblast Interactions I" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:10 pm | Heather Duffy (Beth Israel Deaconess Medical Center)
"Fibrosis and Myocyte-Myofibroblast Interactions II" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Trainee Presentation: Thao Nguyen (UCLA)
"Myocyte-Myofibroblast Interactions Promoting Early Afterdepolarizations" |
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CHANNELOPATHIES AND ARRHYTHMIAS |
| Discussion Leader: Gail A. Robertson (University of Wisconsin-Madison) |
| 9:00 am - 9:25 am | Charles Antzelevitch (Masonic Medical Research Laboratory)
"Arrhythmias and the QT Interval: The Long and Short of It" |
| 9:25 am - 9:40 am | Discussion |
| 9:40 am - 10:05 am | Yoram Rudy (Washington University)
"Molecular Dynamics of LQT1 Syndrome" |
| 10:05 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:15 am | Gideon Koren (Brown University)
"Gender, Age and Long QT Arrhythmias: Insights from Genetic Models" |
| 11:15 am - 11:30 am | Discussion |
| 11:30 am - 11:55 am | Carlo Napolitano (Salvatore Maugeri Foundation)
"Channelopathies Associated with Ca Channel Dysfunction" |
| 11:55 am - 12:10 pm | Discussion |
| 12:10 pm - 12:20 pm | Trainee Presentation: Roshni Madhvani (UCLA)
"Suppressing Early Afterdepolarizations by Modifying the Ca Window Current" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | THE CONDUCTION SYSTEM, PACEMAKING AND BIOLOGICAL PACEMAKER DESIGN |
| Discussion Leader: Peng-Sheng Chen (Indiana University) |
| 7:30 pm - 7:55 pm | Glenn Fishman (New York University)
"Cardiac Conduction System Development" |
| 7:55 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm | Edward Lakatta (National Institute of Aging)
"The Clocks of Cardiac Pacemaking" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:10 pm | Michael Rosen (Columbia University)
"The Road to Biological Pacemakers" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Poster Competition Winner Awards |
| 9:25 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |