Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
The Future of Arrhythmia Therapeutic Development
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:05 pm
"Fatty Acid Modulators as LQT1 Therapeutics"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Human Organotypic Slices as a Platform for Preclinical Drug Studies"
8:40 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Suppressing EADs in Single Cells and VT/VF in Isolated Hearts"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Specificity and Variability in Predictive Modeling
9:00 am - 9:20 am
"Experimentally Calibrated Population of Models Predicts and Explains Inter-Subject Variability"
9:20 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Cell-Specific Models Can Produce More Robust Simulations"
9:55 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Proarrhythmia Predictions Using Primary Human Cardiomyocytes"
11:00 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Predicting Proarrhythmia - The CiPA Initiative"
11:35 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"The Loss of Popeye Domain-Containing Proteins Promote Atrial Arrhythmogenesis in Mice"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Phenotypic Switching After Infarction"
7:50 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Molecular Mechanisms of Arrhythmia in the Brugada and Long QT Syndromes"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Novel Transcription Factors Regulating Cardiac Conduction"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Single-Base Gene Editing Combined with 3D-Super-Resolution Microscopy in hIPSC-CMs to Study SCN5A Mutations Leading to Arrhythmogenic Right Ventricular Cardiomyopathy"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Atrial Fibrillation Is a Dystrophinopathy of the Atria"
9:20 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Patient-Specific Simulations of Atrial Arrhythmia Enable Precision Catheter Ablation"
9:55 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Modulation of Sodium Channel Voltage Sensing in AF"
11:00 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Channelopathies and Cardiac Remodeling in Drosophila "
11:35 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Ultrasound-Based Mapping of Electromechanical Rotors During Cardiac Fibrillation"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"A Novel Mechanism for the Prediction of Gene-Specific Sensitivity to Class-Ib Antiarrhythmic Mexiletine"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechano-Electrical Signaling in Arrhythmia
Session in memory of Max Lab.
7:30 pm - 7:50 pm
"Stretch Effects on Myocytes and Non-Myocytes in the Heart"
7:50 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Mechanical Communication in Synchronized Beating Cardiomyocytes"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Visualizing Electrical and Mechanical Activity"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Ephaptic Coupling in Cardiac Diseases"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Illuminating Arrhythmia: Optogenetics in Research and Therapy
9:00 am - 9:20 am
"Optical Electrophysiology in Excitable Cells: What In Vitro Measurements Can and Cannot Predict About Arrhythmia"
9:20 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Massively Parallel All-Optical Electrophysiology"
9:55 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Novel Optogenetic Methods to Understand and Treat Cardiac Arrhythmia"
11:00 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Optogenetics for Selective Activation of Cardiac Autonomic Nerves"
11:35 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Single-Molecule Fluorescence Imaging of fcAMP Association Dynamics Reveal Ligand-Driven Conformational Changes at Binding Domains in Human Pacemaker HCN Channels"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Transcriptional and Translational Mechanisms in Arrhythmia
7:30 pm - 7:50 pm
"Epigenetics and a Role for miRNA in Arrhythmia"
7:50 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Transcriptional Regulation of Cardiac Depolarization and Repolarization"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Long-Range Transcriptional Control: Connecting GWAS Hits with Biology"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Molecular Remodeling Is an Underlying Mechanism of Global Electrical Heterogeneity and Sudden Cardiac Death"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Targets and Macromolecular Complexes in Cardiac Excitability
9:00 am - 9:20 am
"A New Partner of the Nav1.5 Channel in the Dystrophin-Syntrophin Complex: The Unconventional MAGUK Protein CASK"
9:20 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Regulation of Cardiac Repolarization by Caveolae"
9:55 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Cardiac Connectomes and Arrhythmia"
11:00 am - 11:15 am
Discussion
11:15 am - 11:35 am
"A Novel Transporter in the Heart and Its Functional Roles"
11:35 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"KCNJ2 as a Novel Mechanism of CPVT"
12:10 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Old Targets, New Diseases and Mendelian Mysteries
7:30 pm - 7:50 pm
"Gating Pore Currents in SCN5A Mutations Linked to Complex Cardiac Arrhythmias and Dilated Cardiomyopathy"
7:50 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"iPSC Modeling of Cardiac Arrhythmia"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Do Monogenic Arrhythmia Syndromes Exist? Musings on How Genomics Meets Mendel"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure