Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Using Zebrafish to Understand the Development and Evolution of Skeletal Joints"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Role of BMP Signaling in the Pathogenesis of Osteoarthritis"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"The Cis-Regulatory Architecture of Gdf5 and Its Roles in Joint Development and Osteoarthritis Risk"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cartilage Development and Growth Plate
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Chondrocyte Plasticity and Fate Determination in Development and Disease"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Role of Autophagy in the Pathogenesis of Skeletal Diseases"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
"lncRNA ROCR Is Essential for Chondrocyte Development"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Beta-Catenin Activity in Hypertrophic Chondrocytes Orchestrates Osteoblastogenesis and Osteoclastogenesis at the Chondro-Osseous Border"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"How Do Hypertrophic Chondrocytes Control Resorption of the Growth Plate?"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"Identification of the Roles of SOX9 at the Onset of Chondrogenesis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Evolution of the Skeletal System
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Diet's Impact on Bone Development and Quality"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"Evolution of Hox Regulation and Skeletal Patterning"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:20 pm
"The Evolving Molecular Fingerprint of Skeletal Cells"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:40 pm
"Mechanisms of Articular Cartilage Development and Morphogenesis as Revealed by Progenitor Cell Lineage Tracing"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Articular Cartilage and Osteoarthritis
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Unmasking Endogenous Repair Capabilities of
Articular Cartilage"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"A Small Aggrecan Fragment Causes Osteoarthritis Pain Through TLR2"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Sustained IKKbeta Activation in Postnatal Chondrocytes Accelerates the Onset of Age-Associated Murine Osteoarthritis"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"The Cartilage Circadian Clock in Health and Disease"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Novel Role for CTGF in Postnatal Cartilage"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"DOT1L Safeguards Cartilage Homeostasis and Protects Against Osteoarthritis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cartilage in the Context of the Musculoskeletal System
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Regulation of Musculoskeletal Integration and Tendon
Elongation"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"Regulation of Intervertebral Disc Development by Pax1 and Sox9"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:20 pm
"Site-1 Protease Regulates Skeletal Stem Cell Population in Mice and Impacts both Cartilage and Bone Development"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:40 pm
"Investigating the Contributions of the Immune System to the Development of Cartilage Tumors"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Regulation of Morphogenesis by Secreted Proteases"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Dissecting the Role of Matrix Biomechanics in Skeletal Morphogenesis"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Novel Disease-Linked Aggrecan Mutations and Evidence for ER Stress in Cartilage from Familial Osteochondritis Dissecans Patients"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Circadian Clock Regulation of the Secretory Pathway of Collagen"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Collagen Prolyl 4-Hydroxylases and Lysyl Oxidase in Musculoskeletal Development"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"The Terminal Domains of Osteoadherin Regulate Collagen Fibril Organisation and Matrix Mineral Deposition"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Mechanobiology of Cartilage
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Deconstructing Mechanotransduction as a Drug
Target for Osteoarthritis"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"Adaptation to In Vivo Mechanical Loading in the Mouse Knee"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:20 pm
"Molecular Mechanism of Interzone Formation in Appendicular Skeleton"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:40 pm
"FGFR3 Regulates Primary Cilia Elongation Expanding the Skeletal Ciliopathy Group to Achondroplasia"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Functional Characterisation of the OA Genetic Risk Locus Residing at ALDH1A2, Which Codes for the Retinoic Acid Synthesis Enzyme RALDH2, Identifies Regulatory SNPs as Key Mediators of the Enhanced Susceptibility"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Underlying Osteoarthritis Disease Mechanisms: Linking Development with Age-Related Processes"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
"RNAseq Analysis of Chondrocyte Dedifferentation on Synoviocyte and Tissue Plastic Scaffolds"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"3D Chromatin Interactions Regulate Gene Expression During Skeletal Development"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Heterotopic Endochondral Bone Formation"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"MicroRNAs: Posttranscriptional Modulators of Cellular and Extracellular Cartilage Compartments"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Activin A Is a Required Factor During Initiation as Well as the Early Stages of Heterotopic Ossification in FOP"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"Metabolic Regulation of Cartilage and Bone"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:20 pm
"Anp32a Is a Critical Regulator of Atm and Prevents Oxidative Stress in Cartilage"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:40 pm
"Inhibition of Epigenetic Factor Dnmt3b Within Articular Chondrocytes Coordinates Cellular Metabolic Response During the Development of Osteoarthritis"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure