Sunday 
 
 
4:00 pm - 8:00 pm 
	
Arrival and Check-in
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 7:40 pm 
	
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
 
 
						
7:40 pm - 9:30 pm 
	
 
 
						
7:40 pm - 7:45 pm 
	
Opening Remarks
 
 
						
7:45 pm - 8:10 pm 
	
"Control of Differential Growth Rates in Development and Evolution to Establish Skeletal Proportion" 
 
 
 
						
8:10 pm - 8:20 pm 
	
Discussion
 
 
						
8:20 pm - 8:45 pm 
	
"Pyruvate Dehydrogenase Kinase and Bone Hypoxia" 
 
 
 
						
8:45 pm - 8:55 pm 
	
Discussion
 
 
						
8:55 pm - 9:20 pm 
	
"New Insights into Human Spine Patterning" 
 
 
 
						
9:20 pm - 9:30 pm 
	
Discussion
 
 
						
	Monday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
8:30 am - 9:00 am 
	
Group Photo
 
 
						
9:00 am - 12:30 pm 
	
 
 
						
9:00 am - 9:05 am 
	
Introduction by Discussion Leader
 
 
						
9:05 am - 9:30 am 
	
"Regulation of Osteogenic and Chondrogenic Growth Programs by FGF Signaling Pathways" 
 
 
 
						
9:30 am - 9:40 am 
	
Discussion
 
 
						
9:40 am - 10:05 am 
	
"The Type I Tgfβ Receptor Functions as an Antagonist of BMP Signaling in Cartilage" 
 
 
 
						
10:05 am - 10:15 am 
	
Discussion
 
 
						
10:15 am - 10:25 am 
	
"Creb5 Regulates the Formation of Many Synovial Joints and Maintains the Expression of Lubricin in Articular Chondrocytes" 
 
 
 
						
10:25 am - 10:30 am 
	
Discussion
 
 
						
10:30 am - 11:00 am 
	
Coffee Break
 
 
						
11:00 am - 11:25 am 
	
"Dissecting the Transactivation and Other Activities of the Master Chondrogenic Factor SOX9" 
 
 
 
						
11:25 am - 11:35 am 
	
Discussion
 
 
						
11:35 am - 12:00 pm 
	
"Mitochondria and HIFs in Skeletal Development" 
 
 
 
						
12:00 pm - 12:10 pm 
	
Discussion
 
 
						
12:10 pm - 12:20 pm 
	
"Identifying Signals for Joint Cartilage Specification Using Novel ES Cell Models" 
 
 
 
						
12:20 pm - 12:25 pm 
	
Discussion
 
 
						
12:25 pm - 12:30 pm 
	
General Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Genetic and Epigenetic Programming 
 
 
 
						
7:30 pm - 7:55 pm 
	
"Epigenetic Regulation of Cartilage Energy Metabolism and Tissue Catabolism" 
 
 
 
						
7:55 pm - 8:05 pm 
	
Discussion
 
 
						
8:05 pm - 8:30 pm 
	
"Exploring the Gene Regulatory Landscape in Skeletal Cells" 
 
 
 
						
8:30 pm - 8:40 pm 
	
Discussion
 
 
						
8:40 pm - 8:50 pm 
	
"An Epigenetic Program Mediated by lncRNA-HIT Is Essential for the Maturation and Homeostasis of Articular Cartilage" 
 
 
 
						
8:50 pm - 8:55 pm 
	
Discussion
 
 
						
8:55 pm - 9:05 pm 
	
"Translating Human Height Genetics to Skeletal Biology by Functional Genomics of the Growth Plate" 
 
 
 
						
9:05 pm - 9:10 pm 
	
Discussion
 
 
						
9:10 pm - 9:20 pm 
	
"Foxc1 and Foxc2 Are Required for Growth Plate Organization and Endochondral Bone Formation" 
 
 
 
						
9:20 pm - 9:25 pm 
	
Discussion
 
 
						
9:25 pm - 9:30 pm 
	
General Discussion
 
 
						
	Tuesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Mechanobiology of Cartilage and Joints 
 
 
 
						
9:00 am - 9:05 am 
	
Introduction by Discussion Leader
 
 
						
9:05 am - 9:30 am 
	
"Mechanical Activation and Modulation of TRPV4 and PIEZO1 at the Cell-Substrate Interface" 
 
 
 
						
9:30 am - 9:40 am 
	
Discussion
 
 
						
9:40 am - 10:05 am 
	
"The Role of Nuclear Mechanobiology in Mesenchymal Progenitor Cell Differentiation and Tissue Repair" 
 
 
 
						
10:05 am - 10:15 am 
	
Discussion
 
 
						
10:15 am - 10:25 am 
	
"Primary Cilia Drive Postnatal Articular Cartilage Morphogenesis by Controlling Proteoglycan Production and Chondrocyte Organization" 
 
 
 
						
10:25 am - 10:30 am 
	
Discussion
 
 
						
10:30 am - 11:00 am 
	
Coffee Break
 
 
						
11:00 am - 11:25 am 
	
"Bone/Cartilage Crosstalk in Joint Disease" 
 
 
 
						
11:25 am - 11:35 am 
	
Discussion
 
 
						
11:35 am - 12:00 pm 
	
"Mechanoresponsive Skeletal Stem Cells in Bone Regeneration" 
 
 
 
						
12:00 pm - 12:10 pm 
	
Discussion
 
 
						
12:10 pm - 12:20 pm 
	
"A Fat-Free Mouse Model to Study the Contributions of Metabolic Disturbance to Cartilage Physiology and Pathology" 
 
 
 
						
12:20 pm - 12:25 pm 
	
Discussion
 
 
						
12:25 pm - 12:30 pm 
	
General Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
 
 
						
7:30 pm - 7:35 pm 
	
Introduction by Discussion Leader
 
 
						
7:35 pm - 8:00 pm 
	
"Bioinformatic and Proteomic Approaches to Characterize the ECM of Tissues in Health and Disease" 
 
 
 
						
8:00 pm - 8:10 pm 
	
Discussion
 
 
						
8:10 pm - 8:35 pm 
	
"Endogenous Serine Proteinase Inhibitors in Cartilage Protection and Chondrogenesis" 
 
 
 
						
8:35 pm - 8:45 pm 
	
Discussion
 
 
						
8:45 pm - 8:55 pm 
	
"Effects of Fibrillin-1 Mutations on Joint Health" 
 
 
 
						
8:55 pm - 9:00 pm 
	
Discussion
 
 
						
9:00 pm - 9:10 pm 
	
"Perlecan Knockdown Significantly Alters ECM Assembly During Cartilage Development" 
 
 
 
						
9:10 pm - 9:15 pm 
	
Discussion
 
 
						
9:15 pm - 9:25 pm 
	
"Disturbed Cartilage Matrix Composition and Altered PKA-Regulated Transcription Factor Expression in Articular Cartilage of PACAP and PAC1 Gene Deficient Mice" 
 
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Wednesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Genetic Cartilage Disease 
 
 
 
						
9:00 am - 9:05 am 
	
Introduction by Discussion Leader
 
 
						
9:05 am - 9:30 am 
	
"Transcriptional and Replication Defects in Human Chondrodysplasias" 
 
 
 
						
9:30 am - 9:40 am 
	
Discussion
 
 
						
9:40 am - 10:05 am 
	
"Extraskeletal Cartilage Formation in a Congenital Pediatric Disorder: Mechanisms and Treatment" 
 
 
 
						
10:05 am - 10:15 am 
	
Discussion
 
 
						
10:15 am - 10:25 am 
	
"Deciphering the Role of Stat3 Dependent Bone Development in the Context of Job Syndrome" 
 
 
 
						
10:25 am - 10:30 am 
	
Discussion
 
 
						
10:30 am - 11:00 am 
	
Coffee Break
 
 
						
11:00 am - 11:25 am 
	
"The Role of Superficial Zone Chondrocytes in Articular Cartilage" 
 
 
 
						
11:25 am - 11:35 am 
	
Discussion
 
 
						
11:35 am - 12:00 pm 
	
"GAG Synthesis Impairment in the Group of Chondrodysplasia with Multiple Dislocations" 
 
 
 
						
12:00 pm - 12:10 pm 
	
Discussion
 
 
						
12:10 pm - 12:20 pm 
	
"Proximity Labelling Proteomics Reveals Intracellular Effects of Pathogenic Aggrecan Gene Variant Expression" 
 
 
 
						
12:20 pm - 12:25 pm 
	
Discussion
 
 
						
12:25 pm - 12:30 pm 
	
General Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:00 pm - 7:30 pm 
	
Business Meeting 
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair 
 
 
						
7:30 pm - 9:30 pm 
	
 
 
						
7:30 pm - 7:55 pm 
	
"Large Scale Genetic Studies Highlight Diverse Biological Pathways Involved in Cartilage Degeneration" 
 
 
 
						
7:55 pm - 8:05 pm 
	
Discussion
 
 
						
8:05 pm - 8:30 pm 
	
"Control of Cartilage Homeostasis by the Chromatin Regulator CTCF" 
 
 
 
						
8:30 pm - 8:40 pm 
	
Discussion
 
 
						
8:40 pm - 9:05 pm 
	
"Lessons from Translation: New Targets for Cartilage Repair" 
 
 
 
						
9:05 pm - 9:15 pm 
	
Discussion
 
 
						
9:15 pm - 9:25 pm 
	
"Regulatory Role of EGFR Signaling in Adult Cartilage Homeostasis and Osteoarthritis" 
 
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Thursday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Stem Cells and Cartilage Regeneration 
 
 
 
						
9:00 am - 9:05 am 
	
Introduction by Discussion Leader
 
 
						
9:05 am - 9:30 am 
	
"Resting Zone of the Growth Plate Houses a Unique Class of Skeletal Stem Cells" 
 
 
 
						
9:30 am - 9:40 am 
	
Discussion
 
 
						
9:40 am - 10:05 am 
	
"Cartilage Development and Homeostasis via Pre- and Post-Transcriptional Regulation" 
 
 
 
						
10:05 am - 10:15 am 
	
Discussion
 
 
						
10:15 am - 10:45 am 
	
Coffee Break
 
 
						
10:45 am - 11:10 am 
	
"Hox Function in the Adult Limb Skeleton" 
 
 
 
						
11:10 am - 11:20 am 
	
Discussion
 
 
						
11:20 am - 11:45 am 
	
"Sclerosis of Cartilaginous Endplate Causes Spine Pain" 
 
 
 
						
11:45 am - 11:55 am 
	
Discussion
 
 
						
11:55 am - 12:05 pm 
	
"Disruption of TGFb Signaling in the Scleraxis Cell Lineage Results in Tenocyte Dedifferentiation and Tendon Progenitor Recruitment" 
 
 
 
						
12:05 pm - 12:10 pm 
	
Discussion
 
 
						
12:10 pm - 12:20 pm 
	
"Insights into the Cellular Basis of Intervertebral Disc Disease Gained from the t-Transcriptomes of Single Cells" 
 
 
 
						
12:20 pm - 12:25 pm 
	
Discussion
 
 
						
12:25 pm - 12:30 pm 
	
General Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
New Approaches to Cartilage Therapies 
 
 
 
						
7:30 pm - 7:35 pm 
	
Introduction by Discussion Leader
 
 
						
7:35 pm - 8:00 pm 
	
"Mechanism-Driven Treatment Approach for Compopathy/Pseudoachondroplasia" 
 
 
 
						
8:00 pm - 8:10 pm 
	
Discussion
 
 
						
8:10 pm - 8:35 pm 
	
"Stimulation of Intracellular Proteolysis as a Treatment Trategy for Dwarfism Caused by Mutations in Type X Collagen" 
 
 
 
						
8:35 pm - 8:45 pm 
	
Discussion
 
 
						
8:45 pm - 8:55 pm 
	
"Phosphatase Inhibitors Enhance cGMP Production by NPR2 in Growth Plate Chondrocytes and Could Potentially Be Used to Rescue Bone Growth in Achondroplasia" 
 
 
 
						
8:55 pm - 9:00 pm 
	
Discussion
 
 
						
9:00 pm - 9:10 pm 
	
"SM04690, a Potential Disease-Modifying Treatment for Knee Osteoarthritis, Functions Through Inhibition of CLK2 and DYRK1A, Novel M" 
 
 
 
						
9:10 pm - 9:15 pm 
	
Discussion
 
 
						
9:15 pm - 9:25 pm 
	
"Theobroma Cacao Extracts as a Treatment for FGFR3-Related Disorders" 
 
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Friday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am 
	
Departure