Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
"Control of Differential Growth Rates in Development and Evolution to Establish Skeletal Proportion"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Pyruvate Dehydrogenase Kinase and Bone Hypoxia"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"New Insights into Human Spine Patterning"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Regulation of Osteogenic and Chondrogenic Growth Programs by FGF Signaling Pathways"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"The Type I Tgfβ Receptor Functions as an Antagonist of BMP Signaling in Cartilage"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Creb5 Regulates the Formation of Many Synovial Joints and Maintains the Expression of Lubricin in Articular Chondrocytes"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Dissecting the Transactivation and Other Activities of the Master Chondrogenic Factor SOX9"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Mitochondria and HIFs in Skeletal Development"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Identifying Signals for Joint Cartilage Specification Using Novel ES Cell Models"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genetic and Epigenetic Programming
7:30 pm - 7:55 pm
"Epigenetic Regulation of Cartilage Energy Metabolism and Tissue Catabolism"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Exploring the Gene Regulatory Landscape in Skeletal Cells"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"An Epigenetic Program Mediated by lncRNA-HIT Is Essential for the Maturation and Homeostasis of Articular Cartilage"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
"Translating Human Height Genetics to Skeletal Biology by Functional Genomics of the Growth Plate"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Foxc1 and Foxc2 Are Required for Growth Plate Organization and Endochondral Bone Formation"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanobiology of Cartilage and Joints
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Mechanical Activation and Modulation of TRPV4 and PIEZO1 at the Cell-Substrate Interface"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"The Role of Nuclear Mechanobiology in Mesenchymal Progenitor Cell Differentiation and Tissue Repair"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Primary Cilia Drive Postnatal Articular Cartilage Morphogenesis by Controlling Proteoglycan Production and Chondrocyte Organization"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Bone/Cartilage Crosstalk in Joint Disease"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Mechanoresponsive Skeletal Stem Cells in Bone Regeneration"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"A Fat-Free Mouse Model to Study the Contributions of Metabolic Disturbance to Cartilage Physiology and Pathology"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Bioinformatic and Proteomic Approaches to Characterize the ECM of Tissues in Health and Disease"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Endogenous Serine Proteinase Inhibitors in Cartilage Protection and Chondrogenesis"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Effects of Fibrillin-1 Mutations on Joint Health"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Perlecan Knockdown Significantly Alters ECM Assembly During Cartilage Development"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Disturbed Cartilage Matrix Composition and Altered PKA-Regulated Transcription Factor Expression in Articular Cartilage of PACAP and PAC1 Gene Deficient Mice"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genetic Cartilage Disease
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Transcriptional and Replication Defects in Human Chondrodysplasias"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Extraskeletal Cartilage Formation in a Congenital Pediatric Disorder: Mechanisms and Treatment"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Deciphering the Role of Stat3 Dependent Bone Development in the Context of Job Syndrome"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"The Role of Superficial Zone Chondrocytes in Articular Cartilage"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"GAG Synthesis Impairment in the Group of Chondrodysplasia with Multiple Dislocations"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Proximity Labelling Proteomics Reveals Intracellular Effects of Pathogenic Aggrecan Gene Variant Expression"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 7:55 pm
"Large Scale Genetic Studies Highlight Diverse Biological Pathways Involved in Cartilage Degeneration"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Control of Cartilage Homeostasis by the Chromatin Regulator CTCF"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Lessons from Translation: New Targets for Cartilage Repair"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Regulatory Role of EGFR Signaling in Adult Cartilage Homeostasis and Osteoarthritis"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stem Cells and Cartilage Regeneration
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Resting Zone of the Growth Plate Houses a Unique Class of Skeletal Stem Cells"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Cartilage Development and Homeostasis via Pre- and Post-Transcriptional Regulation"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Hox Function in the Adult Limb Skeleton"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Sclerosis of Cartilaginous Endplate Causes Spine Pain"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Disruption of TGFb Signaling in the Scleraxis Cell Lineage Results in Tenocyte Dedifferentiation and Tendon Progenitor Recruitment"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Insights into the Cellular Basis of Intervertebral Disc Disease Gained from the t-Transcriptomes of Single Cells"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Approaches to Cartilage Therapies
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Mechanism-Driven Treatment Approach for Compopathy/Pseudoachondroplasia"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Stimulation of Intracellular Proteolysis as a Treatment Trategy for Dwarfism Caused by Mutations in Type X Collagen"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Phosphatase Inhibitors Enhance cGMP Production by NPR2 in Growth Plate Chondrocytes and Could Potentially Be Used to Rescue Bone Growth in Achondroplasia"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"SM04690, a Potential Disease-Modifying Treatment for Knee Osteoarthritis, Functions Through Inhibition of CLK2 and DYRK1A, Novel M"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Theobroma Cacao Extracts as a Treatment for FGFR3-Related Disorders"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure