Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Skeletal and Joint Development
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Novel Insights into the Mechanisms of Synovial Joint Cavitation during Mouse Embryo Limb Skeletogenesis"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Wnt5a Signaling in Limb Development and Autosomal Dominant Robinow Syndrome"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Fgfr3 Enhancer Deletion Markedly Improves all Skeletal Features in a Mouse Model of Achondroplasia"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Unraveling Cartilage Morphogenesis: Towards Computational Reconstruction of Growth Plate Temporal Dynamics at Cellular Resolution"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Creb5 Controls its Own Expression, Directly Induces the Synovial Joint-Interzone Regulatory Program, and Coordinates the Patterning of the Intervertebral Disc"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Evolution and Regeneration of the Limb
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Oxygen-Sensitivity and Evolution of Limb Regeneration"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Lizard Tails as Instructive Models of Blastema-Based Cartilage Regeneration"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"How Function in Skeletal Stem Cells is Critical for Signaling Required during Fracture Repair"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Bipedalism in Two Steps: Dual Innovations Underlie the Hominin Pelvis"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Salamander Limb Regeneration - Regulation and Evolution"
11:25 am - 11:35 am
Discussion
11:35 am - 11:45 am
"An iPSC-Based Model of in Vitro Cartilage Mineralization: Insights into MAFB’s Role in Multicentric Carpotarsal Osteolysis"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Genetic Interactions between Sox9 and Adgrg6 Contribute to Altered Fibrocartilage and Increased Susceptibility to Severe Scoliosis in Mice"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Dynamics of Cellular Heterogeneity of the Human and Mouse Notochordal Cell Lineage. Implications for Intervertebral Disc Development and Degeneration"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Signalling Inside and Outside the Cell
7:30 pm - 7:50 pm
"Intrinsic Articular Cartilage Repair is Driven by Matrix Bound Growth Factors"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Ciliary Variants Reveal Requirements for Chondrogenic and Osteogenic Differentiation of Cranial Neural Crest Cells"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Inhibition of Lsd-1 Maintains Articular Cartilage Integrity in a Murine Post-Traumatic OA Model"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"A Cartilage-Enriched G Protein-Coupled Receptor Maintains Articular Cartilage Homeostasis via Promoting Gs Signaling in Mice"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Integrin Alpha10 is Involved in the Response of Chondrocytes to Dynamic Compression"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Targeting SHP2 using SHP2D26 PROTAC Degrader to Promote Articular Cartilage Anabolism and Homeostasis"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Genomics and Epigenomics: Nature and Nurture
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Epigenomics in Cartilage Development and Disease: MicroRNAs and More"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Epigenetic Regulation of Aging and Osteoarthritis"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Defining the Developmental Mechanisms in Cartilage That Underly Adolescent Idiopathic Scoliosis in Females"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Leveraging Epigenomic Datasets to Elucidate Genetic Risk of Musculoskeletal Disease"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"From Osteoarthritis Genetics to the Clinic: Identifying Biological Pathways and Drug Repurposing Possibilities"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"From Genomics and Epigenomics to Disease Phenotyping OA"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Using hPSC-Derived Models and CRISPR Cas 9 Gene Editing To Explore TLR4’s Contribution to Cartilage Inflammation and Degradation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Examining the Role of the Splicing Factor SRSF3 in Cartilage Differentiation and Osteoarthritis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Extracellular Matrix in Health and Disease
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"The Cartilage Micromechanical Environment: Linking Extracellular Matrix to Tissue Function"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Role and Mechanisms of Cartilage Calcification in OA"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"Spatial and Diurnal Variations in Sodium Content within Intervertebral Disc Tissue"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Agrin Is a Key Protective Component of the Inflammatory-Response in Early OA"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"Osteogenesis Imperfecta-Causing Mutations in KDELR2 Lead to Impaired Collagen Secretion and Quality in the Skeletal System and Affect Survival of Mice and Zebrafish"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanobiology and Biomechanics
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Modeling Biomechanics in the Zebrafish Jaw Throughout the Life Span: Influences of Aging and Genetic Mutations"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Predicting Cartilage Adaptation in KOA Patients: Where in Vitro Research Meets Multi-Scale Modeling"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Athletic Giftedness and Genetics"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Late-Breaking Topic
11:10 am - 11:20 am
Discussion
11:20 am - 11:30 am
"Multiscale Mechanobiology of Articular Cartilage: Insights From In Silico and In Vitro Approaches"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Metabolic Stress Accelerates Dysregulated Synovial Macrophage-Fibroblast Communication and HTRA1 Overproduction in Osteoarthritis"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Regulation of Postnatal Skeletal Development by Mechanosensitive Osteolectin+ Cells"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"The Function of Plastin-3, an Actin-Binding and -Bundling Protein, in Cartilage Homeostasis"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tissue Engineering and Stem Cell Biology
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"A Platform to Evaluate Fetal Chondrocyte Gene Regulatory Networks in Human Chondrocytes"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Mechanoregulation of Joint Tissues in Development and Disease"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"Sca!old Microarchitecture Drives Vascularization of a Cartilaginous Template for Bone Formation"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Non-Viral Gene Delivery using Engineered Extracellular Vesicles to Reprogram Human Annulus Fibrosus Cells on 3D-Matrices Mimicking Health and Disease"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"Neural Crest-Derived Chondrocytes as a Promising Cell Source for Cartilage Regeneration"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Cartilage Disease: Pathogenesis and Drug Discovery
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Matrix Protein Anabolic Indices Identify Regenerative Cartilage Small RNAs"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Advancing Osteoarthritis Therapeutics by Defining Cartilage Progenitors and their Regulatory Niche"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"A WNK2 Mutation Associated With Familial Osteoarthritis Induces Bone Remodeling in Response to Injury"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Old Knees, New Insights. Exploring the Relationship between Osteoarthritis, Aging, and Fat"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Electromechanical Grading of Human Tibia Plateau Cartilage to Associate Transcriptome Patterns with OA-Pathology"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Drug Repurposing in Rare Bone Diseases"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Development and Screening of Extracellular Matrix Reporter Cells for Cartilage Regeneration in Osteoarthritis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Imaging Mass Cytometry Reveals Distinct Synovial Cell Immunophenotypes in Overloading and Surgical OA Models"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging Technologies and Models
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Mass-Production of Advanced Micromaterials for Scalable Production of Modular Living Tissues"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Multiphoton Microfabrication and Micropatterning (MMM) Platform Technology for Cell Niche Engineering"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"Unravel the Phenotype of Chondrocytes in the Zone of Calcified Cartilage and their Response to Osteoarthritic Factors"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"A Novel Injectable Regenerative OA Therapy"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Village-in-a-Dish: Population Genetic in a Dish To Investigate Osteoarthritis Heterogeneity"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure