Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: From Fundamental Biology to Novel Therapies
7:40 pm - 8:20 pm
"The Evolving Roles of Platelets in Health and Disease"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"GPVI: From Accessory Physiological Role to Major Therapeutic Asset"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Platelet Signaling: Lipids, Granules and Membranes
9:00 am - 9:25 am
"Activation of Platelet Function Through Adhesion G Protein-Coupled Receptors"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Putting It All Together: Integrating the Platelet Signaling Network and the Hemostatic Response to Injury"
10:05 am - 10:20 am
Discussion
10:20 am - 10:30 am
"12-HETrE Exerts Its Antithrombotic Effects Through the Prostacyclin Receptor"
10:30 am - 10:35 am
Discussion
10:35 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Platelet Ballooning: Transforming Cell Shape for Procoagulant Activity"
11:20 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Class II PI3Ks in Platelet Membrane Structure and Function"
12:00 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"AADACL1
Regulates Platelet Granule Secretion and Thrombosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Embryonic and Ontological Development of Megakaryocytes and Platelets
6:00 pm - 6:25 pm
"Exploring the Mechanism of Platelet Formation During Prenatal Life"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"Insights into the Transition from Neonatal to Adult Megakaryopoiesis"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
"Single Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Haematopoietic Cells"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Developing Live Imaging Strategies to Analyze MEP Fate Decisions at the Single Cell Level"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Achilles' Heels: Identifying the Causes of Congenital Platelet Disorders
9:00 am - 9:25 am
"Inherited Thrombocytopenias: Bleeding and Much More"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"ETV6-Related Thrombocytopenia: Lessons from Humans and Animal Models"
10:05 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Programmed Cell Death of Platelets and Megakaryocytes in Wiscott-Aldrich Syndrome"
10:30 am - 10:35 am
Discussion
10:35 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Finding Novel Genes for Inherited Bleeding Disorders with Platelet Dysfunction"
11:20 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Role of FLNA and DIAPH1 in Macrothrombocytopenia - From Functional Studies to Diagnosis or Vice-Versa ?"
12:00 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Inherited Loss of the Arp2/3 Complex Component ARPC1B Results in Microthrombocytes and Predisposes to Inflammatory Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Backbone
of the Lineage: TPO and c-Mpl Signalling in Health and Disease
6:00 pm - 6:25 pm
"Expression and Roles of the Mpl Receptor in Health and Disease"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"New Insights into Thrombopoietin Receptor Activation"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
"Clinical Effects of TPO Agents Inform Disease Biology"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Endocytosis of the Thrombopoietin Receptor Mpl Regulates both Megakaryocyte and Erythroid Progenitors and Is Critical for Myelofibrosis Development"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Myeloproliferative Neoplasms and Acute Megakaryoblastic Leukemia
9:00 am - 9:25 am
"Mechanisms of Acute Megakaryoblastic Leukemia in Non-Down Syndrome Patients"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia"
10:05 am - 10:20 am
Discussion
10:20 am - 10:30 am
"One Cell at a Time: A Single-Cell Approach to Exploring Normal and Malignant Megakaryopoiesis"
10:30 am - 10:35 am
Discussion
10:35 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Aberrant Megakaryopoiesis in the Myeloproliferative Neoplasms"
11:20 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Activation of the Thrombopoietin Receptor by Mutant Calreticulin in CALR-Mutant Myeloproliferative Neoplasms"
12:00 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Activation of JAK/STAT Signaling in Megakaryocytes Is Necessary and Sufficient for Myeloproliferation In Vivo "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Form and Function: Cytoskeletal Regulation in Megakaryocytes and Platelets
6:00 pm - 6:25 pm
"Role of Cytoskeleton-Regulatory Proteins in Platelet Production and Function"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"Actomyosin, Key Player at Multiple Steps in Platelet Biogenesis"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
"Platelet Actin Organisation – Peeking Beyond the Diffraction Limit"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Water Channel Aquaporin-1 Regulates Platelets' Procoagulant Response and In Vivo Thrombus Formation"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Platelets, Inflammation and Innate Immunity
9:00 am - 9:25 am
"Platelets and Innate Immunity: From Mechanism to Populations"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Platelets and Platelet-Derived Microparticles in Antibody-Mediated Inflammatory Responses"
10:05 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Platelet Desialylation: Novel Mechanism of Immune Tolerance"
10:30 am - 10:35 am
Discussion
10:35 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Inflammation-Induced Emergency Hematopoiesis"
11:20 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"The Balance Between Inflammation and Thrombosis During Gram-Negative Infection"
12:00 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Emperipolesis Is a Novel Cell-in-Cell Phenomenon that Mediates Transfer of Neutrophil Membrane to Megakaryocytes and Platelets"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Tumour Cells and Platelets: Une Affaire Compliquée
6:00 pm - 6:25 pm
"Signaling Roles of Platelets During Metastatic Seeding"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"Emerging Role of Platelets in Adaptive Changes to Anti-Angiogenesis Therapy"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
"Platelets and Tumor Cells: Breaking the Cycle"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Inhibition of Platelet Activity by Pim Kinase Inhibitors. A Novel Mechanism of Regulation of Thromboxane A2 Receptor Signalling"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure