Sunday
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4:00 pm - 8:00 pm |
Arrival and Check-in
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
|
7:40 pm - 9:30 pm |
Keynote Session: From Fundamental Biology to Novel Therapies
Discussion Leader: Jack Levin (UCSF School of Medicine, USA)
|
7:40 pm - 8:20 pm |
Andrew Weyrich (University of Utah School of Medicine, USA)
"The Evolving Roles of Platelets in Health and Disease"
|
8:20 pm - 8:35 pm |
Discussion
|
8:35 pm - 9:15 pm |
Martine Jandrot-Perrus (Laboratory for Vascular Translational Science (LVTS), Paris Diderot University, France)
"GPVI: From Accessory Physiological Role to Major Therapeutic Asset"
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9:15 pm - 9:30 pm |
Discussion
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Monday
|
7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Platelet Signaling: Lipids, Granules and Membranes
Discussion Leader: Elizabeth Gardiner (Australian National University, Australia)
|
9:00 am - 9:25 am |
Junling Liu (Shanghai Jiao Tong University School of Medicine, China)
"Activation of Platelet Function Through Adhesion G Protein-Coupled Receptors"
|
9:25 am - 9:40 am |
Discussion
|
9:40 am - 10:05 am |
Lawrence Brass (University of Pennsylvania, USA)
"Putting It All Together: Integrating the Platelet Signaling Network and the Hemostatic Response to Injury"
|
10:05 am - 10:20 am |
Discussion
|
10:20 am - 10:30 am |
Selected from Poster Abstracts: Benjamin Tourdot (University of Michigan, USA)
"12-HETrE Exerts Its Antithrombotic Effects Through the Prostacyclin Receptor"
|
10:30 am - 10:35 am |
Discussion
|
10:35 am - 10:55 am |
Coffee Break
|
10:55 am - 11:20 am |
Alastair Poole (University of Bristol, United Kingdom)
"Platelet Ballooning: Transforming Cell Shape for Procoagulant Activity"
|
11:20 am - 11:35 am |
Discussion
|
11:35 am - 12:00 pm |
Justin Hamilton (Monash University, Australia)
"Class II PI3Ks in Platelet Membrane Structure and Function"
|
12:00 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:25 pm |
Selected from Poster Abstracts: Stephen Holly (University of North Carolina at Chapel Hill, USA)
"AADACL1
Regulates Platelet Granule Secretion and Thrombosis"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:30 pm |
Free Time
|
3:00 pm - 4:00 pm |
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Elizabeth Gardiner (Australian National University, Australia) and Kellie Machlus (Harvard Medical School, USA)
|
4:30 pm - 6:00 pm |
Poster Session
|
6:00 pm - 8:00 pm |
Embryonic and Ontological Development of Megakaryocytes and Platelets
Discussion Leader: James Palis (University of Rochester Medical Center, USA)
|
6:00 pm - 6:25 pm |
Samir Taoudi (The Walter and Eliza Hall Institute of Medical Research, Australia)
"Exploring the Mechanism of Platelet Formation During Prenatal Life"
|
6:25 pm - 6:35 pm |
Discussion
|
6:35 pm - 7:00 pm |
Martha Sola-Visner (Boston Children's Hospital, USA)
"Insights into the Transition from Neonatal to Adult Megakaryopoiesis"
|
7:00 pm - 7:10 pm |
Discussion
|
7:10 pm - 7:35 pm |
Ana Cvejic (University of Cambridge, United Kingdom)
"Single Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Haematopoietic Cells"
|
7:35 pm - 7:45 pm |
Discussion
|
7:45 pm - 7:55 pm |
Selected from Poster Abstracts: Vanessa Scanlon (Yale University, USA)
"Developing Live Imaging Strategies to Analyze MEP Fate Decisions at the Single Cell Level"
|
7:55 pm - 8:00 pm |
Discussion
|
8:00 pm - 9:00 pm |
Dinner
|
Tuesday
|
7:30 am - 8:30 am |
Breakfast
|
8:30 am - 9:00 am |
Group Photo
|
9:00 am - 12:30 pm |
Achilles' Heels: Identifying the Causes of Congenital Platelet Disorders
Discussion Leader: Kathleen Freson (Katholieke Universiteit Leuven, Belgium)
|
9:00 am - 9:25 am |
Patrizia Noris (Fondazione IRCCS Policlinico San Matteo / University of Pavia, Italy)
"Inherited Thrombocytopenias: Bleeding and Much More"
|
9:25 am - 9:40 am |
Discussion
|
9:40 am - 10:05 am |
Jorge Di Paola (University of Colorado, USA)
"ETV6-Related Thrombocytopenia: Lessons from Humans and Animal Models"
|
10:05 am - 10:20 am |
Discussion
|
10:20 am - 10:30 am |
Selected from Poster Abstracts: Mikhail Panteleev (Federal Research and Clinical Center of Pediatric Hematology, Oncology and Immunology, Russia)
"Programmed Cell Death of Platelets and Megakaryocytes in Wiscott-Aldrich Syndrome"
|
10:30 am - 10:35 am |
Discussion
|
10:35 am - 10:55 am |
Coffee Break
|
10:55 am - 11:20 am |
Neil Morgan (University of Birmingham, United Kingdom)
"Finding Novel Genes for Inherited Bleeding Disorders with Platelet Dysfunction"
|
11:20 am - 11:35 am |
Discussion
|
11:35 am - 12:00 pm |
Najet Debili (INSERM, France)
"Role of FLNA and DIAPH1 in Macrothrombocytopenia - From Functional Studies to Diagnosis or Vice-Versa?"
|
12:00 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:25 pm |
Selected from Poster Abstracts: Walter Kahr (University of Toronto, Canada)
"Inherited Loss of the Arp2/3 Complex Component ARPC1B Results in Microthrombocytes and Predisposes to Inflammatory Disease"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:30 pm |
Free Time
|
4:30 pm - 6:00 pm |
Poster Session
|
6:00 pm - 8:00 pm |
Backbone
of the Lineage: TPO and c-Mpl Signalling in Health and Disease
Discussion Leader: Nichola Cooper (Imperial College Healthcare, United Kingdom)
|
6:00 pm - 6:25 pm |
Warren Alexander (Walter and Eliza Hall Institute of Medical Research, Australia)
"Expression and Roles of the Mpl Receptor in Health and Disease"
|
6:25 pm - 6:35 pm |
Discussion
|
6:35 pm - 7:00 pm |
Ian Hitchcock (University of York, United Kingdom)
"New Insights into Thrombopoietin Receptor Activation"
|
7:00 pm - 7:10 pm |
Discussion
|
7:10 pm - 7:35 pm |
James Bussel (Weill Cornell Medicine, USA)
"Clinical Effects of TPO Agents Inform Disease Biology"
|
7:35 pm - 7:45 pm |
Discussion
|
7:45 pm - 7:55 pm |
Selected from Poster Abstracts: Herve Falet (Blood Research Institute, BloodCenter of Wisconsin, USA)
"Endocytosis of the Thrombopoietin Receptor Mpl Regulates both Megakaryocyte and Erythroid Progenitors and Is Critical for Myelofibrosis Development"
|
7:55 pm - 8:00 pm |
Discussion
|
8:00 pm - 9:00 pm |
Dinner
|
Wednesday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
Myeloproliferative Neoplasms and Acute Megakaryoblastic Leukemia
Discussion Leader: Warren Alexander (Walter and Eliza Hall Institute of Medical Research, Australia)
|
9:00 am - 9:25 am |
Tanja Gruber (St. Jude Children's Research Hospital, USA)
"Mechanisms of Acute Megakaryoblastic Leukemia in Non-Down Syndrome Patients"
|
9:25 am - 9:40 am |
Discussion
|
9:40 am - 10:05 am |
Thomas Mercher (Institut Gustave Roussy, France)
"ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia"
|
10:05 am - 10:20 am |
Discussion
|
10:20 am - 10:30 am |
Selected from Poster Abstracts: Bethan Psaila (National Institutes of Health, USA / University of Oxford, United Kingdom)
"One Cell at a Time: A Single-Cell Approach to Exploring Normal and Malignant Megakaryopoiesis"
|
10:30 am - 10:35 am |
Discussion
|
10:35 am - 10:55 am |
Coffee Break
|
10:55 am - 11:20 am |
John Crispino (Northwestern University, USA)
"Aberrant Megakaryopoiesis in the Myeloproliferative Neoplasms"
|
11:20 am - 11:35 am |
Discussion
|
11:35 am - 12:00 pm |
Marito Araki (Juntendo University Graduate School of Medicine, Japan)
"Activation of the Thrombopoietin Receptor by Mutant Calreticulin in CALR-Mutant Myeloproliferative Neoplasms"
|
12:00 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:25 pm |
Selected from Poster Abstracts: Qiang Wen (Northwestern University, USA)
"Activation of JAK/STAT Signaling in Megakaryocytes Is Necessary and Sufficient for Myeloproliferation In Vivo"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:30 pm |
Free Time
|
4:30 pm - 6:00 pm |
Poster Session
|
6:00 pm - 8:00 pm |
Form and Function: Cytoskeletal Regulation in Megakaryocytes and Platelets
Discussion Leader: Antonija Begonja (University of Rijeka, Croatia)
|
6:00 pm - 6:25 pm |
Markus Bender (University Hospital Wuerzburg, Germany)
"Role of Cytoskeleton-Regulatory Proteins in Platelet Production and Function"
|
6:25 pm - 6:35 pm |
Discussion
|
6:35 pm - 7:00 pm |
Catherine Leon (INSERM U949, EFS-Alsace, Université de Strasbourg, France)
"Actomyosin, Key Player at Multiple Steps in Platelet Biogenesis"
|
7:00 pm - 7:10 pm |
Discussion
|
7:10 pm - 7:35 pm |
Steve Thomas (University of Birmingham, United Kingdom)
"Platelet Actin Organisation – Peeking Beyond the Diffraction Limit"
|
7:35 pm - 7:45 pm |
Discussion
|
7:45 pm - 7:55 pm |
Selected from Poster Abstracts: Ejaife Agbani (University of Bristol, United Kingdom)
"Water Channel Aquaporin-1 Regulates Platelets' Procoagulant Response and In Vivo Thrombus Formation"
|
7:55 pm - 8:00 pm |
Discussion
|
8:00 pm - 9:00 pm |
Dinner
|
Thursday
|
7:30 am - 8:30 am |
Breakfast
|
8:30 am - 9:00 am |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
9:00 am - 12:30 pm |
Platelets, Inflammation and Innate Immunity
Discussion Leader: Peter Nigrovic (Brigham and Women's Hospital, USA)
|
9:00 am - 9:25 am |
Jane Freedman (University of Massachusetts Medical School, USA)
"Platelets and Innate Immunity: From Mechanism to Populations"
|
9:25 am - 9:40 am |
Discussion
|
9:40 am - 10:05 am |
Eric Boilard (CHU de Quebec, Universite Laval, Canada)
"Platelets and Platelet-Derived Microparticles in Antibody-Mediated Inflammatory Responses"
|
10:05 am - 10:20 am |
Discussion
|
10:20 am - 10:30 am |
Selected from Poster Abstracts: June Li (University of Toronto, Canada)
"Platelet Desialylation: Novel Mechanism of Immune Tolerance"
|
10:30 am - 10:35 am |
Discussion
|
10:35 am - 10:55 am |
Coffee Break
|
10:55 am - 11:20 am |
Marieke Essers (Heidelberg Institute for Stem Cell Technology and Experimental Medicine, Germany)
"Inflammation-Induced Emergency Hematopoiesis"
|
11:20 am - 11:35 am |
Discussion
|
11:35 am - 12:00 pm |
Adam Cunningham (University of Birmingham, United Kingdom)
"The Balance Between Inflammation and Thrombosis During Gram-Negative Infection"
|
12:00 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:25 pm |
Selected from Poster Abstracts: Pierre Cunin (Brigham and Women's Hospital, USA)
"Emperipolesis Is a Novel Cell-in-Cell Phenomenon that Mediates Transfer of Neutrophil Membrane to Megakaryocytes and Platelets"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:30 pm |
Free Time
|
4:30 pm - 6:00 pm |
Poster Session
|
6:00 pm - 8:00 pm |
Tumour Cells and Platelets: Une Affaire Compliquée
Discussion Leader: Emma Josefsson (The Walter and Eliza Hall Institute of Medical Research, Australia)
|
6:00 pm - 6:25 pm |
Myriam Labelle (St. Jude Children's Research Hospital, USA)
"Signaling Roles of Platelets During Metastatic Seeding"
|
6:25 pm - 6:35 pm |
Discussion
|
6:35 pm - 7:00 pm |
Anil Sood (University of Texas MD Anderson Cancer Center, USA)
"Emerging Role of Platelets in Adaptive Changes to Anti-Angiogenesis Therapy"
|
7:00 pm - 7:10 pm |
Discussion
|
7:10 pm - 7:35 pm |
Elisabeth Battinelli (Brigham and Women's Hospital / Harvard Medical School, USA)
"Platelets and Tumor Cells: Breaking the Cycle"
|
7:35 pm - 7:45 pm |
Discussion
|
7:45 pm - 7:55 pm |
Selected from Poster Abstracts: Amanda Unsworth (University of Reading, United Kingdom)
"Inhibition of Platelet Activity by Pim Kinase Inhibitors. A Novel Mechanism of Regulation of Thromboxane A2 Receptor Signalling"
|
7:55 pm - 8:00 pm |
Discussion
|
8:00 pm - 9:00 pm |
Dinner
|
Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
|