Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Megakaryocytes and Platelet: Nature and Nurture
7:40 pm - 8:00 pm
General Discussion
8:00 pm - 8:35 pm
"The Biblical Problem with Thrombopoiesis"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
"Shaping Platelets: How 3D Niche Models Unlock Megakaryocyte Mysteries Beyond 2D Cultures"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Deconstructing Megakaryocytes
9:00 am - 9:20 am
"Megakaryocyte Direct Differentiation from Hematopoietic Stem Cells"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"To Bleed or not to Bleed: A Stem Cell Question"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Alternative Platelet Differentiation Pathways Initiated by Nonhierarchically Related Hematopoietic Stem Cells"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
"The Secret(e) and Not-So-Secret Lives of Megakaryocytes"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Extramedullary Megakaryocytes: Insights from Cleared Tissue Imaging and Spatial Transcriptomics"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Back to The Future or License to Chill? Platelet Transfusions in 2025"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Genetic Engineering of Transfusable Donor Platelets with mRNA-Lipid Nanoparticles"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Ex Vivo Genetic and Pharmacological Targeting of RHOA in Platelet Therapy"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Effects of Platelet Transfusion on Neonatal Bleeding and Inflammation"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Next Generation Synthetic Platelet Technologies for Hemostatic Therapy"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Platelet Production and Function
9:00 am - 9:20 am
"Megakaryo-Sites: Engineered Bone Marrow Niches and their Effects on MK Biology"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"CXCL12 Abundant Reticular (CAR) Cells Spatially Regulate Platelet Production in the Bone Marrow"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"In Vivo Visualization of Megakaryopoiesis Within the Intact Bone Marrow"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Megakaryocyte-Neutrophil Emperipolesis Yields Procoagulant Platelets"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Aging Platelets Shift Their Hemostatic Properties to Inflammatory Functions"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"GPIbα Signaling and Crosstalk"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Personalized 3D Vessel-on-Chip: Towards 'Sherlock Holmes' Approach to Detecting Blood Clots"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Rogue Megakaryocytes and Platelets
7:30 pm - 7:50 pm
"Traveling to Enchanted Lands to Find Genes for Platelet Traits"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Hiding in Plain Site: When Thrombocytopenia is More Than a Megakaryocyte Thing"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Platelet Reactivity Expression Score (PRESS): Time to Revisit our Approach to Antiplatelet Therapy using Precision Based Care"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Tet2 Age-Associated Somatic Mutations Impair Megakaryopoiesis and Platelet Function in Clonal Hematopoiesis"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Platelets Sequester Extracellular DNA, Captured Tumour-Derived and Free Fetal DNA"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Inflamed Megakaryocytes, Platelets and Vessels
9:00 am - 9:20 am
"Platelet Factors Attenuate Inflammation and Rescue Cognition in Aging"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"The Journey of Megakaryocytes Through the Immune Fields"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Loss of Layilin Augments Platelet Activation via RAC1 in Inflammatory Bowel Disease"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Identification of Distinct Hemostatic Mechanisms Linked to Endothelial Necroptosis and Apoptosis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Platelet-Neutrophil Interactions: Kiss of Death or Lifesaver?"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Intersections, Not Tangents: The Crosstalk Between Neutrophil Proinflammatory Responses and Platelets"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Platelets in the Immune Crossfire
7:30 pm - 7:50 pm
"FcRn: Can’t Leave Home Without it"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Untangling the NET: How Platelet Collaborate with Neutrophil Extracellular Traps to Promote Immune Homeostasis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Highway to the Danger Zone: Locking on PF4 to Take Down HIT"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Complement Activation in HIT"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Megakaryocyte and Platelet Regulators
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Granule Cargo Packaging and Release from Platelets and Megakaryocytes: Roles and Perspectives"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"When Platelet Mitochondria Never Ever Get Back Together"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
General Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Thrombo-Olfaction: New Targets for Antiplatelet Therapy"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Targeted Platelet Therapy: Unlocking the Power of PROTACs"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Phosphodiesterase 5 (PDE5) Hydrolyzes Elevated cAMP Levels in Megakaryocytes and Platelets"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Yap/Taz Regulated Megakaryocyte Cytoskeleton to Control Platelet Formation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Platelet Therapeutics
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:20 pm
"From Crystal to Clinical Trial: The Zalunfiban (RUC-4) Story"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:05 pm
"Platelet Immune Receptors: Completing the Jigsaw"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure