| Saturday |
| 1:30 pm - 4:30 pm | Arrival and Check-in |
| 3:00 pm - 3:15 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:15 pm - 4:00 pm | Keynote Session: Megakaryocytes and Platelets in Health and Disease |
| Discussion Leaders: Matthew Harper (University of Cambridge, United Kingdom) and Joe Italiano (Brigham and Women's Hospital / Harvard University, USA) |
| 3:15 pm - 3:45 pm | Robert Flaumenhaft (Beth Israel Deaconess Medical Center, USA)
"Chemical Genetics of Platelet Biology" |
| 3:45 pm - 4:00 pm | Discussion |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | Megakaryocyte and Platelet Cell Biology |
| Discussion Leaders: Natalie Poulter (University of Birmingham, United Kingdom) and Kellie Machlus (Brigham and Women's Hospital / Harvard Med. Sch., USA) |
| 5:30 pm - 5:45 pm | Edward Brown (University of Bristol, United Kingdom)
"High
Resolution 3D Reconstruction of Large Megakaryocyte Protrusions into Bone
Marrow Sinusoids" |
| 5:45 pm - 5:50 pm | Discussion |
| 5:50 pm - 6:05 pm | Maria Colzani (University of Cambridge, NHSBT, United Kingdom)
"Recreating the 3D Bone Marrow Environment: Producing Platelets In Vitro for Transfusion" |
| 6:05 pm - 6:10 pm | Discussion |
| 6:10 pm - 6:25 pm | Siying Zou (Yale University, USA)
"ARHGEF12 Plays Important Roles in Megakaryocyte Differentiation and Platelet Function" |
| 6:25 pm - 6:30 pm | Discussion |
| 6:30 pm - 6:45 pm | Florian Gaertner (LMU Munich, Germany)
"Single Cell Tracking Reveals Autonomous Locomotion as a Platelet Function Facilitating Thrombus Reorganization" |
| 6:45 pm - 6:50 pm | Discussion |
| 6:50 pm - 7:05 pm | Gabriela Lesyk (University of Alberta, Canada)
"Pharmacological Characterization of eNOS-Based Platelet Subpopulations" |
| 7:05 pm - 7:10 pm | Discussion |
| 7:10 pm - 7:25 pm | Arti Trivedi (Hull York Medical School, United Kingdom)
"Association of Type
1 Inositol 1,4,5-Trisphosphate Receptor (IP3R1) with Protein Kinase A and
A-Kinase Anchoring Protein 9 (AKAP9) in Platelets" |
| 7:25 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Megakaryocytes and Platelets in Disease |
| Discussion Leaders: Marilena Crescente (University of Reading, United Kingdom) and Robert Law (Hull York Medical School, United Kingdom) |
| 9:00 am - 9:15 am | Hannah Bader (Boston University School of Medicine, USA)
"Thrombocytopenia
in a Mouse Model that Over-Expresses the Hypoxia-Inducible Factor 2 Alpha
(HIF-2α)" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Sarah Fletcher (University of Birmingham, United Kingdom)
"Consecutive SLFN14 Mutations in 3 Unrelated Families with an Inherited Bleeding Disorder, Thrombocytopenia and Secretion Defects" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Carmela Martino (University of South Australia, Australia)
"Platelets and
Vasculogenic Mimicry by Tumour Cells" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Alice Pollitt (University of Birmingham, United Kingdom)
"Syk and Src Family
Kinases Regulate CLEC-2-Mediated Clustering of Podoplanin and Platelet Adhesion to Primary Lymphatic Endothelial Cells" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Stefanie Novakowski (University of British Columbia, Canada)
"Delivery of Exogenous
RNA to Platelets by Nanoliposomes" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 11:00 am | General Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Mentorship Component: Developing an Independent Research Career |
| Discussion Leaders: Benjamin Kile (Walter and Eliza Hall Institute for Medical Research, Australia) and Joe Italiano (Brigham and Women's Hospital / Harvard University, USA) |
| 1:30 pm - 1:45 pm | Wolfgang Bergmeier (University of North Carolina at Chapel Hill, USA)
"Developing an Independent Research Career" |
| 1:45 pm - 2:00 pm | Discussion |
| 2:00 pm - 2:15 pm | Ingeborg Hers (University of Bristol, United Kingdom)
"Developing an Independent Research Career" |
| 2:15 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
