1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Keynote Session: Platelets and Inflammation
Beth Webb (University of Leeds, United Kingdom)
3:15 pm - 3:20 pm
Introduction by Discussion Leader
3:20 pm - 3:50 pm
Julie Rayes (University of Birmingham, United Kingdom) "Platelet and Neutrophil Cooperation in Driving Thrombo-Inflammation During Infection"
3:50 pm - 4:00 pm
4:00 pm - 5:30 pm
5:30 pm - 7:30 pm
Platelets in Health and Disease
Vanessa Göb (University Würzburg, Germany) and Joshua Lykins (University of Kentucky, United States)
5:30 pm - 5:40 pm
Claudia Schönichen (Maastricht University, The Netherlands) "Inflammatory Endothelial Cells Regulate Platelet Reactivity: Using Multi-Omics to Decipher Endothelial (Dys)Regulation of Platelets in Inflammatory Vessel-On-A-Chip-Models"
5:40 pm - 5:45 pm
5:45 pm - 5:55 pm
Genevieve Marcoux (Lund University, Sweden) "Platelet Derived Extracellular Vesicles Suppress Transfusion-Related Acute Lung Injury (TRALI)"
5:55 pm - 6:00 pm
6:00 pm - 6:10 pm
Marcin Sowa (NYU Grossman School of Medicine, United States) "P2Y12 Inhibition Suppresses Platelet Interferon-Associated Responses"
6:10 pm - 6:15 pm
6:15 pm - 6:25 pm
Sarah Beck (University of Würzburg, Germany) "Spatio-Temporal Control of Fibrin Formation by Platelet Glycoprotein V"
6:25 pm - 6:30 pm
6:30 pm - 6:40 pm
Sonia Aguila (Centro Regional de Hemodonación, IMIB, Spain) "MiR-146a Has a Pleiotropic Role in Platelets Driving Metabolic Reprogramming and Tuning Reactivity and Thrombosis Threshold"
6:40 pm - 6:45 pm
6:45 pm - 6:55 pm
Vijay Bhoopalan (John curtin school of medical research, ANU, Australia) "Ribosomal Biogenesis Inhibition Facilitates Megakaryocyte/Platelet-Biased Haematopoiesis"
6:55 pm - 7:00 pm
7:00 pm - 7:10 pm
Danielle Karakas (University of Toronto, Canada) "Novel Mechanisms of Thrombopoietin Generation: The Critical Role of Kupffer Cells"
7:10 pm - 7:15 pm
7:15 pm - 7:25 pm
Bongani Nkambule (NIH/NHLBI, United States) "A Novel Quantitative Flow Cytometry Approach in Determining Platelet Subpopulations and Quantifying Cell Surface Receptors"
7:25 pm - 7:30 pm
8:00 pm - 9:00 pm
7:30 am - 8:30 am
9:00 am - 11:00 am
Megakaryocytes in Health and Disease
Julia Tilburg (Havard Medical School, United States) and Ana Marin Quilez (Centro Regional de Hemodonación - IMIB, Murcia, España, Spain)
9:00 am - 9:10 am
Rubia Isler Mancuso (Yale University, United States) "CRISPR Optimization to Screen for Genes That Regulate Fate Specification of Primary Hematopoietic Progenitors"
9:10 am - 9:15 am
9:15 am - 9:25 am
Giulia Della Rosa (University of Pavia, Italy) "Live-Monitoring of Human Megakaryocyte Function and Metabolism in a Silk-Based Three-Dimensional Bone Marrow Niche Model"
9:25 am - 9:30 am
9:30 am - 9:40 am
Abdullah Khan (University of Oxford, United Kingdom) "Vascularised Bone Marrow Organoids for the Study of Healthy and Diseased Megakaryocyte Biology"
9:40 am - 9:45 am
9:45 am - 9:55 am
Alison Livada (University of Rochester School of Medicine and Dentistry, United States) "Lung Megakaryocytes are Tissue Resident, Arise Independent of HSCs, and Contribute to Recovery in Low Platelet States"
9:55 am - 10:00 am
10:00 am - 10:10 am
Anthony Yeung (Boston University Center for Regenerative Medicine, United States) "De-novo Hematopoiesis from the Fetal Lung"
10:10 am - 10:15 am
10:15 am - 10:25 am
Sophie Nock (Manchester Metropolitan University, United Kingdom) "Pim kinase: A Novel Regulator of Megakaryocyte and Platelet Production and Function"
10:25 am - 10:30 am
10:30 am - 10:40 am
Elsa Barré (EFS UMRS_1255, France) "Effects of the Shp2 Allosteric Inhibitor SHP099 on Megakaryopoiesis and Thrombopoiesis"
10:40 am - 10:45 am
10:45 am - 10:55 am
Ryan Collinson (University of Western Australia, Australia) "Loss of TCF3 Regulation in Megakaryocytes is Associated with Bone Marrow Fibrosis in Myeloproliferative Neoplasms"
10:55 am - 11:00 am
11:00 am - 12:30 pm
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
1:30 pm - 2:30 pm
Mentorship Component: Building a Career in Academia
Alessandra Balduini (University of Pavia, Italy)
1:30 pm - 2:30 pm
Amanda Unsworth (Manchester Metropolitan University, United Kingdom)
Anandi Krishnan (Stanford University, United States)
2:30 pm - 3:00 pm
Complete the GRS Evaluation Forms; Election of Future Chair(s)