Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
"Meeting Your Quota: The Cellular Economy of Zinc"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Mining Metalloproteome by Chemical and Computational Proteomics"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Structural and Functional Characterization of Processes for Copper Transport and FeS Protein Biogenesis"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metals at the Host-Pathogen Interface
9:00 am - 9:25 am
"In Vitro Reconstitution and Mechanistic Dissection of Iron Transport at the Host-Pathogen Interface for Legionella pneumophila "
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Vitamin B12 and Other Metal-Based Mechanisms in Bacterial Light Sensing and Signaling"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"Feeding on the Host: How Do Human Fungal Pathogens Acquire Essential Trace Metals During Infection?"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Iron Utilization by Malaria Parasites"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Bacterial Adaptation to Manganese Starvation: A Tale of Two Enzymes"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Transcriptional and Translational Reprogramming in Response to Copper Status in the Pathogenic Fungus Cryptococcus neoformans "
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cellular Metal Sensation and Homeostasis
6:00 pm - 6:25 pm
"Molecular Mechanisms of Bacterial Metallostasis"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"Regulatory and Metabolic Responses to Iron Deficiency"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
"Zinc Sensing and Signaling in C. elegans "
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Selective Recognition and Utilization of Lanthanides in Biology"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:25 am
"A Novel Liver/Gut/Microbiota Axis Control Iron Homeostasis"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Serum and Tissue Iron Sensing by the Liver"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"An Unexpected Role for Metal Transporters in Systemic Metabolism"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Out-of-Balance: Pathophysiological Consequences of Iron Overload"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Hepatic Bioenergetic Deficiency Induces a Novel Signal that Systemically Suppresses the Immune System"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Role of Zinc at Neuronal Nerve Terminals"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Bile Acid Regulation of Intestinal Manganese Transport"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cellular Metal Partitioning
6:00 pm - 6:25 pm
"Ironing-out the Connection Between Mitochondria and Lysosomes"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"Mitochondrial Copper Transporter Modulates Targets Inside and Outside of Mitochondria"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
"Handling Heme: Probing the Mechanisms Underlying Heme Trafficking and Utilization"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Grab Regulates Endosomal Trafficking of The Transferrin Receptor in Developing Erythroblasts"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:25 am
"Molybdenum Cofactor Synthesis and Enzymes in Mitochondria"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Enzymology of Heme Biosynthesis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"The Special Relationship Between Cobalt and the Corrin Ring of Vitamin B12"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Unraveling the Complex(ity) of Heme Synthesis and Distribution"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Understanding Cobalt Acquisition for Vitamin B12"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Structural Basis of Zinc-Dependent Protein Quality Control in the Early Secretory Pathway"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Control of Heme Biosynthesis and Acquisition in Staphylococcus aureus "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
New Paradigms in Metal Metabolism
6:00 pm - 6:25 pm
"How Cells Import Copper and Cope with Copper Deficiency"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"Understanding Bacterial Metal Defense via Single-Molecule/Cell Microscopy"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
"Zinc Regulation of the Mammalian Cell Cycle"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Uncovering Essential Metal Interactions in the Gut Microbiota: A Study on Lactobacillus plantarum and Zinc"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Metals in Physiology and Disease
9:00 am - 9:25 am
"Cardiovascular Iron Homeostasis"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Manganese Homeostasis and Induced-Parkinsonism: Insights from Studies of a Rare Genetic Disease"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"Lessons from Porphyrias: Disproportion of Iron and Heme"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Mechanisms of ATP7A-Related Copper Transport Diseases"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Post-Transcriptional Regulation of Atp7a mRNA in Skeletal Muscle Myoblasts"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"New Roles of Transcription Factor Spic in Inflammation and Iron Metabolism"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Cadmium Accumulation in Insulin Producing Beta Cells in the Pathophysiology of Type 2 Diabetes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Cellular Metal Compartmentalization and Regulation
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:45 pm
"Metal Dynamics: From the Soil to the Seed"
6:45 pm - 7:00 pm
Discussion
7:00 pm - 7:05 pm
Introduction by Discussion Leader
7:05 pm - 7:45 pm
"Biogenesis of Iron-Sulfur Proteins in Eukaryotes: Mitochondria, Mitosomes, Mechanisms and Maladies"
7:45 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure