| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | BIOPHYSICAL ANALYSIS OF VESICLE TRAFFIC |
| Discussion Leader: Ron Holz, University of Michigan |
| Timothy A. Ryan, Department of Biochemistry, Room E-107, The Weill Medical College of Cornell University
Biophysical Dissection of the Synaptic Vesicle Cycle |
| Venkatesh N. Murthy, Molecular & Cellular Biology, Harvard University
Regulation of presynaptic vesicle pools |
| Erwin Neher, Max Planck Institute for Biophysical Chemistry
Molecules involved in the Ca2+-triggering of Catecholamine Release from Adrenal Chromaffin cells |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | MECHANISMS IN SYNAPTIC VESICLE EXOCYTOSIS |
| Discussion Leader: Christian Rosenmund, Max Planck Institute for Biophysical Chemistry, Germany |
| Reinhard Jahn, Max Planck Institute for Biophysical Chemistry
Insights in to the conformational cycles of SNARE proteins |
| Janet Richmond, University of Utah
UNC-18 promotes synaptic synaptic vesicle docking in C. elegans |
| Charles F. Stevens, The Salk Institute
Structure/funtion studies of synaptotagmin |
| 10:00 am | Coffee Break |
| Thomas F. Martin, University of Wisconsin, Department of Biochemistry
Membrane fusion and retrieval of dense-core vesicles |
| Josep Rizo, University of Texas Southwestern Medical Center
Structural insights into teh last steps of Ca2+-evoked neurotransmitter release |
| Kang Shen, UCSF
Molecular mechanism of synaptic specificity in C. elegans |
| Kimbely Mcallister, University of California, Davis
Rapid recruitment of NMDAR subunits to nascent synapses |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | DEVELOPMENT OF THE SYNAPSE |
| Discussion Leader: James Rand, Oklahoma Medical Research Foundation |
| Graeme W. Davis, University of California San Francisco, Department of Biochemistry
Molecular and Genetic Analysis of Synapse Development |
| Yishi Jin, Howard Hughes Medical Institute, University of California, Santa Cruz, Department of Biology
Neuronal polarity specification in C. elegans |
| Peter Scheiffele, Columbia University, Dept of Physiology
Cellular Interactions and Gene Expression Changes that Drive Synaptic Differentiation in the CNS |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | THE NEURONAL CYTOSKELETON |
| Discussion Leader: Bettina Winckler, Mount Sinai School of Medicine |
| Frank Gertler, Massachusetts Institute of Technology, Biology
Regulation of the actin cytoskeleton during cell and growth cone migration |
| David L. Van Vactor, Department of Cell Biology, DFCI/Harvard Cancer Center
From Growth Cone to Synapse: Receptor Phosphatase Regulation of Cellular Morphogenesis |
| 10:00 am | Coffee Break |
| Nabutaka Hirokawa, Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo
The Mechanism of Transport of Synaptic Vesicle Proteins and
Receptors in Neuron: Molecular Cell Biology of Kinesin Superfamily Proteins, KIFs |
| Shelley Halpain, Scripps Institute, Department of Cell Biology
Cytoskeletal Remodeling in Neurite Formation |
| Mani Ramaswami, University of Arizona
CREB, AP1 and the transcriptional control of plasticity synapse |
| Gianpietro Schiavo, Cancer Research, UK
Endocytosis and retrograde traffic of tetanus toxin in motor neurons |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | REGULATORY MECHANISMS |
| Discussion Leader: Edward Stuenkel, The Salk Institute |
| Thomas C. Sudhof, University of Texas Southwestern Medical Center
Molecular anatomy of the presynaptic active zone |
| A.J. Hudspeth, Howard Hughes Medical Institute, Rockefeller University
Mechanical amplification of acoustic signals by ion channels of hair cells |
| Richard W. Tsien, Stanford University, School of Medicine, Department of Molecular & Cellular Physiology
Calcium signaling, gene transcription and synaptic homeostasis |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | PRESYNAPTIC MATRIX AND ENDOCYTOSIS |
| Discussion Leader: Phillip J. Robinson, Children's Medical Institute, Australia |
| 9:00 am - 10:00 am | Craig C. Garner, University of Alabama at Birmingham
Quantal assembly of presynaptic active zones |
| Harvey McMahon, MRC Laboratory of Molecular Biology, Cambridge, UK
Lipid-protein interactions in clathrin-mediated endocytosis |
| Sylwia Wasiak, McGill University
A novel clathrin assembly protein identified through subcellular proteomics |
| Oleg Shupliakov, Karolinska Institute, Nobel Institute for Neurophysiology, Dept of Neuroscience
Membrane traffic at the edge of the active zone: a lamprey perspective |
| 10:00 am | Coffee Break |
| Yukiko Goda, MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, University College London
Activity-dependent remodeling of synaptic actin cytoskeleton |
| Ling-Gang Wu, Washington University
Single and multiple vesicle fusion induce different rates of endocytosis at a central synapse |
| Thomas Schikorski, The Salk Institute
Multivesicle endocytosis |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | SYNAPTIC PLASTICITY |
| Discussion Leader: Bonnie Firestein, Rutgers University |
| Kelsey Martin, Depts. of Psychiatry and Biological Chemistry, UCLA Brain Research Institute
mRNA localization and local translation during synaptic plasticity |
| Karel Svoboda, Cold Spring Harbor Lab
experience-dependent synaptic plasticity in vivo |
| Joshua Kaplan, University of California, Berkeley, Department of Molecular & Cell Biology
Mechanisms regulating glutamate receptor abundance at C. elegans synapses |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | SIGNALING MECHANISMS |
| Discussion Leader: Tony Koleske, Yale University |
| Joachim Herz, University of Texas, Southwestern Medical Center, Department of Melecular Genetics
Mechanisms of Signaling by Neuronal ApoE receptors |
| Lawrence S. Goldstein, Howard Hughes Medical Institute, University of California San Diego
Linking Kinesin-Dependent Transport Pathways to Signaling and Disease |
| John Gerard Flanagan, Harvard Medical School, Cell Biology
Axon guidance and neural map specification by ephrins |
| 10:00 am | Coffee Break |
| Li-Huei Tsai, Harvard Medical School
Cellular and molecular mechanisms underlying neuronal migration in the developing CNS |
| Gilbert Di Paolo, Yale University School of Medicine
Membrane targeting of PIP kinase type Iy at the synapse |
| Matthew Dalva, Children's Hospital, Harvard Medical School
A role for EphB in synapse development: regulating NMDA receptor localization and function |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | POST-SYNAPTIC MECHANISMS |
| Discussion Leader: Ed Ziff, NYU School of Medicine |
| Richard L. Huganir, Howard Hughes Medical Institute, Department of Neuroscience, The Johns Hopkins University School of Medicine
Regulation of Glutamate Receptor Function and Synaptic Plasticity
|
| Mary B. Kennedy, California Institute of Technology
What can we learn from stochastic kinetic modeling of synaptic signaling? |
| Mark McNiven, Mayo Clinic
Dynamin 3 as a mediator of synaptic morphogenesis |
| Morgan Sheng, Center for Learning and Memory and HHMI, Massachusetts Institute of Technology
Glutamate receptor trafficking and synaptic plasticity |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
