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Cell Contact and Adhesion

Gordon Research Conference

Cell Junctions as Integrators of Molecular and Mechanical Signals in Development and Disease

June 2 - 7, 2019

Chair

Vice Chair

Les Diablerets Conference Center

Eurotel Victoria

Les Diablerets, Vaud (fr), Switzerland

Venue and Travel Information

Conference Description

Intercellular and matrix adhesion collectively define the physical and molecular signaling interface between cells and their environment. Beyond simple glue-like functions, adhesion receptors play key roles in regulating proliferation, migration, differentiation, and essential aspects of the signaling state of the cell. The 2019 Cell Contact and Adhesion Conference will feature the latest results in cell adhesion biology, utilizing the full diversity of cutting edge methods in cell and molecular biology, biochemistry, engineering, and biophysics. There will also be several talks featuring fundamentally new functions for adhesion in regulating tissue level biology in both development and disease states.

Related Meeting

This GRC will be held in conjunction with the "Cell Contact and Adhesion" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
4:00 pm - 8:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Keynote Session: The Molecular Basis of Intercellular Adhesion Discussion Leader:
7:40 pm - 7:55 pm	Opening Remarks
7:55 pm - 8:40 pm	"Cell-Cell Adhesion Studies: History and Perspective"
8:40 pm - 9:10 pm	Discussion
9:10 pm - 9:30 pm	General Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Molecular Regulation of Cell-Cell Junctions Discussion Leader:
9:00 am - 9:25 am	"Mechanisms of Signalling at Apical Epithelial Junctions"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	"Surprising Functions of Desmosomal Cadherins in Development and Disease"
10:00 am - 10:10 am	Discussion
10:10 am - 10:25 am	Selected from Poster Abstracts: "Reciprocal Regulation of AJ and TJ During the Assembly of Apical Adhesion Complex"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:25 am	"Cytoskeletal Integration of Biochemical and Adhesive Cues"
11:25 am - 11:35 am	Discussion
11:35 am - 12:00 pm	"Coupling Mechanotransduction and Cell Metabolism"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	Selected from Poster Abstracts: "Using Optogenetic Tools to Determine How Local Tight Junction Leaks and the Rho Flare Repair Mechanism Are Triggered"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Group Photo / Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Mechanotransduction Through Adhesion Receptors Discussion Leader:
6:00 pm - 6:25 pm	"Force-Dependent Allosteric Regulation of Alpha-Catenin Binding to F-Actin by Vinculin"
6:25 pm - 6:35 pm	Discussion
6:35 pm - 6:50 pm	Selected from Poster Abstracts: "The Desmosome Is Mechanically Loaded in Response to Externally Applied Stress"
6:50 pm - 6:55 pm	Discussion
6:55 pm - 7:20 pm	"Modeling the Collective Behavior of Confluent Adhesive Cells"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:45 pm	Selected from Poster Abstracts: "Dynamic Actomyosin Pulses Induce Tension Imbalance to Drive Epithelial Cell Extrusion"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:00 pm	General Discussion
8:00 pm - 9:00 pm	Dinner
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Cell-Cell Adhesion as a Regulatory Mechanism During Development Discussion Leader:
9:00 am - 9:25 am	"Dynamics of Proliferative Epithelial Tissue"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	"Molecular and Mechanical Regulation of Tissue Morphogenesis"
10:00 am - 10:10 am	Discussion
10:10 am - 10:25 am	Selected from Poster Abstracts: "Defining the Role of the Adherens Junction-Actin Cytoskeletal Linker Canoe/Afadin in Epithelia Integrity and Morphogenesis"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:25 am	"Control and Self-Organization in Tissue Morphogenesis"
11:25 am - 11:35 am	Discussion
11:35 am - 12:00 pm	"Multi-Level Regulation of the Crumbs Polarity Protein Controls the Dynamics of Epithelial Cell Ingression"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	Selected from Poster Abstracts: "Mind the srGAP: Novel Roles for a Slit-Robo GAP During Epithelial Morphogenesis"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Quantitative Analysis of Adhesion Dynamics Discussion Leader:
6:00 pm - 6:25 pm	"Mind the Gap: Physical Segregation of Proteins at Cell-Cell Contacts"
6:25 pm - 6:35 pm	Discussion
6:35 pm - 6:50 pm	Selected from Poster Abstracts: "Cell-Cell Adhesion Regulation in Mitosis and Ploidy"
6:50 pm - 6:55 pm	Discussion
6:55 pm - 7:20 pm	"Cadherins and Growth Factor Receptors in Force Transduction"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:45 pm	Selected from Poster Abstracts: "Sensing of Forces by Asymmetric Endothelial Junctions for Angiogenesis"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:00 pm	General Discussion
8:00 pm - 9:00 pm	Dinner
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Adhesive Regulation of Cell Behavior Discussion Leader:
9:00 am - 9:25 am	"Mechanobiology of Epithelial Growth and Folding"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	"Mechanisms of Nuclear Mechanoprotection and Mechanoadaptation"
10:00 am - 10:10 am	Discussion
10:10 am - 10:25 am	Selected from Poster Abstracts: "Emergence of Single Cell Mechanical Behavior and Polarity Within Epithelial Monolayers Drives Collective Cell Migration"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:25 am	"Epithelial Renewal in Gut Homeostasis"
11:25 am - 11:35 am	Discussion
11:35 am - 12:00 pm	"Epithelial Function and Monolayer Integrity in Chronic Obstructive Pulmonary Disorder"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	Selected from Poster Abstracts: "Nectin-Elicited Cytoplasm Transfer: A Process Accounting for Infection of Neurons by Measles Virus"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Non-Canonical Roles of Adhesion Receptors Discussion Leader:
6:00 pm - 6:25 pm	"Upside Down Polarity"
6:25 pm - 6:35 pm	Discussion
6:35 pm - 6:50 pm	Selected from Poster Abstracts: "Structural Principles in Robo Activation and Auto-Inhibition"
6:50 pm - 6:55 pm	Discussion
6:55 pm - 7:20 pm	"Collective Cell Dynamics of Organ Renewal"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:45 pm	"An Adhesion Code Enables Robust Pattern Formation in the Zebrafish Spinal Cord"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:00 pm	General Discussion
8:00 pm - 9:00 pm	Dinner
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm	Adhesive Regulation of Cancer Cell Invasion and Metastasis Discussion Leader:
9:00 am - 9:25 am	"Loss of Epithelial Cell Adhesion and Breast Cancer Dormancy"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	"Multistep Fluidization of Multicellular Invasion"
10:00 am - 10:10 am	Discussion
10:10 am - 10:25 am	Selected from Poster Abstracts: "E-cadherin Is an Invasion Suppressor, Survival Factor, and Metastasis Promoter in Multiple Models of Breast Cancer"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:25 am	"Neighbourhood Watch by Cell-Cell Mechanotransduction"
11:25 am - 11:35 am	Discussion
11:35 am - 12:00 pm	"Flow Signaling at Endothelial Cell-Cell Junctions"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	"Affinity of ZO-1 to Actin Modulates Barrier Function"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Keynote Session: Regulation of Morphogenesis by Adhesion Discussion Leader:
6:00 pm - 6:10 pm	Introduction by Discussion Leader
6:10 pm - 7:00 pm	"Planar Cell Polarity: From Cell Adhesion to Tissue Mechanics"
7:00 pm - 7:25 pm	Discussion
7:25 pm - 7:45 pm	General Discussion
7:45 pm - 8:00 pm	Closing Remarks
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Keith R. Porter Endowment for Cell Biology

Conference Links

Conference History Cell Contact and Adhesion (GRS)

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