Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Cell Signaling and Cancer
Discussion Leader: Sydney Moyer (University of Texas MD Anderson Cancer Center, USA)
3:45 pm - 4:25 pm
Kornelia Polyak (Dana-Farber Cancer Institute, USA)
"Breast Tumor Evolution"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Aneuploidy, Cell Cycle and Diseases
Discussion Leader: Eva Moreno (Utrecht University, The Netherlands)
7:30 pm - 7:45 pm
Evgeny Zatulovskiy (Stanford University, USA)
"Cell Growth Dilutes the Cell Cycle Inhibitor RB to Trigger Cell Division"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Anand Vasudevan (Cold Spring Harbor Laboratory, USA)
"The Role of Single Chromosome Gains in Metastasis"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Shyama Nandakumar (University of Michigan, USA)
"Polyploidy in the Aging Drosophila melanogaster Brain"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Christine Scaduto (Cold Spring Harbor Laboratory, USA)
"Are Cancer Cells Addicted to Aneuploidy?"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Juanita Limas (University of North Carolina at Chapel Hill, USA)
"A Novel Way of Blocking Origin Licensing and Recapitulating Early Oncogene Activation"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Nisha Peter (Sussex Drug Discovery Centre, University of Sussex, United Kingdom)
"Identifying a Phenotypic Signature of MASTL Depletion in Breast Cancer Cell Lines Using High-Content Imaging"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Cell Cycle Control and Regulation
Discussion Leader: Geeta Kumari (Dana Farber Cancer Institute, USA)
9:00 am - 9:15 am
Paula Bucko (University of Washington, USA)
"SNAP-Based Inhibition of Localized Kinase Activity Reveals the Roles of Aurora A and Polo-Like Kinase 1 at the Centrosome During Mitosis"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Orlando Arguello-Miranda (University of Texas Southwestern Medical Center, USA)
"Machine Learning Single Cell Analysis of the Transition from Proliferation into Quiescence"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Sean Hourihane (Institute of Molecular and Cell Biology, A*STAR, Singapore)
"Investigating the Interface of Dynamic Regulatory Gene Expression with the Cell Cycle"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Joseph Ong (University of California, Los Angeles, USA)
"Cul3 Substrate Adaptor SPOP Degrades Nuclear Pore Complex Protein NupJ"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Gemma Wilson (MRC Laboratory for Molecular Cell Biology, University College London, United Kingdom)
"Structurally Distinct CDK7 Inhibitors Prevent Cellular Proliferation via Different Mechanisms"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Lotte Watts (University of Aberdeen, United Kingdom)
"The Long RIF1 Splice Variant Protects Cells from Replication Stress by Promoting 53BP1 Nuclear Body Formation in the Following G1 Phase"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Alternative Careers in Science
Discussion Leader: Andrea Chaikovsky (Stanford University, USA)
1:30 pm - 1:55 pm
Stephen Dann (Pfizer Oncology Research Discovery, USA)
"Research Career in Industry"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:25 pm
Mira Chaurushiya (5AM Ventures, USA)
"Beyond the PhD: Bench Science to Venture Capitalist"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes