Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The Exposome: A Framework for Toxicology at a Grand Scale
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Using the Exposome to Study Adverse Events at a Population Level"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Analytics for Interrogating Exposomes and Phenomes in Disease and Health"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Diverse Tissues, Diverse Responses: Delving into Organ Toxicity
9:00 am - 9:30 am
"Evaluating Diet-PFAS Interactions in Models of Obesity and NAFLD"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Environmental PPARγ and RXR Ligands: Selective Agonists that Disrupt Bone and Adipose Homeostasis"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Flavoring Chemicals and Pulmonary Cellular Toxicological Responses"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Evaluation of the Relative Performance of Pancreas Specific microRNAs in Rat Plasma as Biomarkers of Pancreas Injury"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"Evaluation of the Relevance of DILI Predictive Hypotheses in Early Drug Development: Review of In Vitro Methodologies vs BDDCS Classification"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advances at the Interface of Toxicology and Medicine: Toward Prevention and Treatment of Toxicant-Mediated Disease
7:30 pm - 8:00 pm
"From the Most Dangerous Dioxin to the Most Profitable Weed Killer: Environmental Risks of Multiple Myeloma"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Mechanisms of Toxicant Associated Steatohepatitis in Translational Studies"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"The Application of Library Screening Technologies to Translational Small Molecule Discovery Investigations"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Nuclear Receptors Old and New: Novel Pharmacological and Toxicological Targets
9:00 am - 9:30 am
"Nuclear Receptors in Drug Discovery"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Targeted Nuclear Receptor Modulation of the Gut-Liver Axis in Xenobiotic Biotransformation"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Hepatocyte Nuclear Factor 4 Alpha: A Novel (and Often Ignored) Toxicant Target"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Epigenome-Based Predictive Modeling of Tissue-Specific Nuclear Receptor Signaling Networks"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"Induction of the Antioxidant Response by NRF2 Signaling Increases Bioactivation of the Mutagenic Air Pollutant 3-Nitrobenzanthrone in Human Lung Cells"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Applications of Microphysiological Systems in Toxicological Research
7:30 pm - 8:00 pm
"Microphysiological Systems, Mechanisms of Action, and Chronotoxicology"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Translational Applications of Tissue Chip Technologies"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Application of Organs on Chips in Pharma Industry: The Need, Gaps and the Vision"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Early-Career Investigator Presentations
9:00 am - 9:30 am
"Aryl Hydrocarbon Receptor: The Good, the Bad and the Toxic"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Environmental Exposures and Stem Cell Reprogramming: Understanding Racial Disparities in Triple Negative Breast Cancer"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Epigenetics and Public Health"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Arsenic Modulates Glucocorticoid Receptor Signaling in Placenta"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"In Vitro Evaluation of Anthracycline-Induced Cardiotoxicity and Mitigation by Perturbation of Angiotensin Signalling"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Testing Beyond Animals: Pushing the Frontiers in Safety Evaluation
7:30 pm - 8:00 pm
"In Vivo 5-Day Transcriptomics Approach to Estimating Points of Departure"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"From Plates to Human: Validating Assays with Investigative Toxicology"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Bridging the Gap with RISK21: Risk Assessment in the 21st Century"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Emerging Technologies and Alternative Testing Strategies
9:00 am - 9:30 am
"Using 3D Organotypic Cultures to Model Cancer Biology and Treatment Response"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Therapeutic Strategies via Genome Engineering: New Approaches and Challenges"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Rewiring of the 3D Genome in Inorganic Arsenic-Mediated Carcinogenesis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Predictive Toxicogenomics Space Modeling Serves Effectively to Sensitive Biomarker-Based Read Across from Capturing Toxic Mode-of-Action of Lowest-Observable Effect Levels"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"Molecular Basis of the 'Baseline Response' and 'Transient Response' Observed in the Newly Designed Repeated Dose Study: Epigenetic Modifications"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Utilizing Big Data and Quantitative Systems Modeling to Derive Outcomes
7:30 pm - 8:10 pm
"Utilizing Big Data and Systems Modeling to Derive a Widely Applicable Predictive Toxicogenomics Space Tool"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 9:05 pm
"Quantitative Mechanistic High Content Data for Predictive Systems Toxicology Modelling"
9:05 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure