Modern Mechanistic Approaches to Toxicology Research and Application

The Cellular and Molecular Mechanisms of Toxicity (CMMT) GRC is an internationally recognized stage on which state-of-the art mechanistic toxicology is featured. The goal of the CMMT is to bridge the intersection between risk assessment, drug and chemical safety, public health, and science policy related to mechanistic toxicology. The conference is held over 5 days in a remote location to increase connectivity between conferees and build community. Two keynote sessions and seven themed scientific sessions will highlight current research being conducted by renowned scientists from around the globe. A select number of abstract submissions will be chosen to deliver “late-breaking” oral presentations during scientific sessions throughout the week.

The 2025 CMMT builds upon its rich history of cutting-edge science, inclusive networking and career development for members of the mechanistic toxicology community. The keynote sessions will feature translational talks on the toxicological implications of nucleic acid therapies and genomic modification, and the potential applications of artificial intelligence in mechanistic toxicology. Themed scientific sessions will cover the concepts of in vitro models for new drug modalities, xenobiotic-induced immunomodulation, modern high-resolution and spatial molecular technologies in toxicology, integration of high dimensional data into risk assessment, and the toxicological implications of climate change. We also will hold our featured early-career scientist session, inviting talks from emerging investigators across academia, industry, and government internationally, complemented by oral presentations by two trainees selected during the preceding GRS. The CMMT program will also offer a GRC Power Hour™, a highlight session that provides opportunities to discuss issues and challenges facing scientists from minoritized backgrounds in STEM. Overall, this program provides a forward-looking overview of modern toxicological challenges and applications. All conferees are strongly encouraged to submit abstracts, contributing to scientific advancement and discourse through oral or poster presentations. Late-breaking speakers selected from the pool of abstracts will be notified at least one month in advance of the meeting. Students and postdoctoral scholars are especially encouraged to also apply for the associated GRS, a 2-day seminar preceding the GRC created for trainees and led by trainees. All GRS conferees are also strongly encouraged to apply to this GRC as well.