Genetic and Epigenetic Mechanisms with Implications for Development and Disease

Centromeres are chromosomal loci that function to ensure chromosome segregation in every cell division cycle. Defective centromere function can lead to aneuploidy, contributing to cancer, fertility and developmental disorders. Due to the highly repetitive nature of the DNA sequences that underly centromeres in most organisms, these regions of the genome were largely excluded from previous genome sequencing and assembly efforts. However, in the last few years, breakthroughs in sequencing technologies (such as longer sequencing read lengths) and the development of advanced computational tools have overcome this barrier. Moreover, the determining the basis of centromere function in chromosome segregation has relied on a breadth of cell biological, biophysical, genomic and structural advancements. Researchers in this field are now armed with an unprecedented knowledge of the genetic, epigenetic and structural components that comprise centromeres. Combined with advances in genome editing and high-resolution cellular and molecular imaging technologies, centromere biologists are well positioned to elucidate exactly how this critical locus functions to ensure genome stability.

The goal of the Centromere Biology conference is to bring together a community of vibrant researchers from diverse disciplines to substantially advance current understanding of how this unique genomic locus is specified and functions in mitosis and meiosis. It will convene outstanding scientists in the field interested in all aspects of centromere biology, including those with expertise in the kinetochore and chromosome segregation machinery and in flanking pericentromeric regions. Speakers will present cutting edge findings that represent a broad range of disciplines including genomics, bioinformatics, genetics, epigenetics, biochemistry, biophysics, structural biology, cell and molecular biology and evolution. Discussion among international experts in this rapidly growing field will identify and shape key questions and approaches moving forward. This meeting will support a strong representation from researchers from all career stages and diverse backgrounds.