Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The Ever Changing Landscape of Threats to Human Health and Security
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:15 pm
"OP or Not OP, that Is the Question"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:50 pm
"How Concerned Should We Be About Gene Drive Technologies?"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Public
Perception of Chemical and Biological Terrorism"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Neural Dysfunction: Mechanisms, Detection, and Countermeasures
9:00 am - 9:15 am
Introduction by Discussion Leader: Introduction and Perspectives on Emerging Issues and Innovative Solutions for Threat Agents Targeting Neural Function
9:15 am - 9:45 am
"Using Novel Enzymes to Protect Against Organophosphorus Toxicity"
9:45 am - 9:55 am
Discussion
9:55 am - 10:15 am
"Intraneuronal Delivery of Single Domain Antibodies for Treatment of Post-Symptomatic Botulism"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
"Botulinum Toxin - From Biothreat to Biomedicine"
11:25 am - 11:35 am
Discussion
11:35 am - 12:05 pm
"A Tale of Two Threat Agents: OPs and TETS"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Host Interactions and Responses
7:30 pm - 7:45 pm
Introduction by Discussion Leader: Introduction and Perspectives on Host Immunity and
Threat Agents
7:45 pm - 8:10 pm
"Your Own Worst Enemy: How Yersinia pestis Turns the Body Against Itself"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Combining Mechanistic and Global Insights to Identify Critical Interactions Between Pathogen and Host"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Alternative Roles for CRISPR-Cas Systems in Bacterial Pathogenesis"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Host Barrier Function and Dysfunction
9:00 am - 9:15 am
Introduction by Discussion Leader: Overview and Perspectives on the Host Barriers, and How Biological and Chemical Threat Agents Might Affect Barrier Function
9:15 am - 9:45 am
"Inflammatory Mechanisms of Lung Injury Induced by Mustard Vesicants"
9:45 am - 9:55 am
Discussion
9:55 am - 10:20 am
"Rebuilding the Damaged Lung"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Imaging Mass Spectrometry: Untargeted Molecular Histology at the Host-Pathogen Interface"
11:25 am - 11:35 am
Discussion
11:35 am - 12:05 pm
"Antimicrobial Signaling at the Maternal-Fetal Interface"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:45 pm
Introduction by Discussion Leader: Overview and Perspectives on the the Targeting of Metabolism by Threat Agents
7:45 pm - 8:10 pm
"Metabolic Targets: Modeling and Predictions"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Nuclear Receptors Control Pro-Viral and Antiviral Metabolic Responses to Hepatitis C Virus Infection"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Targeting Viruses Through Cellular Metabolism"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Extended and Emerging Threats to Human Health
and Security
9:00 am - 9:15 am
Introduction by Discussion Leader: Perspectives and Overviews on Extended and Emerging Threats to Human Health and Security
9:15 am - 9:45 am
"CRISPR/Gene Grives: Potential Threats in Plants and Agriculture"
9:45 am - 9:55 am
Discussion
9:55 am - 10:25 am
"From WMDs to CMBs: What Creative Malicious Biologists Could Do, but Haven't"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Building Cyberthreat Models for Genomic Security"
11:25 am - 11:35 am
Discussion
11:35 am - 12:05 pm
"Real-Time Genomic Surveillance of Pathogen Evolution and Spread"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Looking Ahead: Young Investigator Presentations / Alternative Approaches
7:30 pm - 7:40 pm
Introduction by Discussion Leader: Perspectives on Emerging Threats and Challenges: A Perspective from the CDC
7:40 pm - 7:55 pm
"The Art of War: Exosomes as Carrier Pigeons of the Cell to Protect from Bacterial Spread During Infection with Yersinia pestis "
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
"Combined Stimulation of a2-Adrenoceptors and GABAA Receptors Abruptly Terminates Soman-Induced Status Epilepticus"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Powerful Science: A Tool of Diplomacy"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Engineering Inhalable Polymeric Prodrugs of Ciprofloxacin for Prophylactic andTherapeutic Treatment of Highly-Lethal Pulmonary Francisella tularensis Infections"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Activating Mitochondrial Quality Control as a Strategy to Combat Mitochondrial Targeted Pathogenic Effectors"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Smart Approaches for Detection, Prevention, and Intervention
9:00 am - 9:15 am
Introduction by Discussion Leader: The Emergence of Smart Solutions to Threat Agents
9:15 am - 9:40 am
"A Platform Technology Based on a Nanocomplex that Actively Crosses the Blood-Brain Barrier and Its Use in Medical Countermeasures Against Both Chemical and Biological Threat Agents"
9:40 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Interrogation of In Vivo Modes of Action of Positron-Labeled Organophosphates and Antidotes with Dynamic PET Imaging"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"You Catch More Flies (and Mosquitoes) with Honey - A New Approach to Automating Surveillance for Arboviruses"
11:25 am - 11:35 am
Discussion
11:35 am - 12:05 pm
"Nanolayered Delivery from Trauma: Delivery Solutions for Field Care Medicine"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Working at the Periphery: Bioengineering-Inspired Solutions for Counteracting Biological and Chemical Threats
7:30 pm - 7:45 pm
Introduction by Discussion Leader: Perspectives and Overview of the Capacity of Bioengineering to Meet the Challenges and Opportunities Associated with Existing and Emerging Threats
7:45 pm - 8:10 pm
"Plant Virus-Based Nanotechnologies"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"High Performance Lateral Flow Assays as First Line of Defense Against Bioagents"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure