Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Crossing the Barrier from Academics to Industry (and Back) |
| Discussion Leaders: Philip Dawson (The Scripps Research Institute, USA) and Anna Maria Papini (University of Florence, Italy / University of Cergy-Pontoise, France) |
7:40 pm - 8:20 pm | Richard DiMarchi (Indiana University, USA) "Peptide-Based Therapeutics: From Hormones to Polypharmacy" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Peter Kim (Stanford University School of Medicine, USA) "Toward an HIV Vaccine" |
9:15 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Peptide Discovery: Biological and Chemical Libraries |
| Discussion Leaders: Kit Lam (UC Davis School of Medicine, USA) and John Nuss (Ferring Research Institute, USA) |
9:00 am - 9:20 am | Introduction by Discussion Leader |
9:20 am - 9:45 am | Thomas Kodadek (The Scripps Research Institute, Scripps Florida, USA) "Synthesis and Screening of Large Libraries of Conformationally Restricted Oligomers" |
9:45 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Richard Roberts (University of Southern California, USA) "Directed Evolution of Scanning Unnatural Protease Resistant (SUPR) Peptides for In Vivo Applications" |
10:25 am - 10:40 am | Discussion |
10:40 am - 11:10 am | Coffee Break |
11:10 am - 11:35 am | Ratmir Derda (University of Alberta, Canada) "Novel Chemical and Genetics Approaches Chemically-Modified Peptide Libraries" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | James Heath (California Institute of Technology, USA) "Precise Epitope Targeting of Synthetic Macrocyclic Peptides for Biomedical Applications" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Peptide Discovery: Where to Look Next |
| Discussion Leaders: Paul Alewood (The University of Queensland, Australia) and Natia Tsomaia (Ipsen, USA) |
7:30 pm - 7:55 pm | Roderich Sussmuth (Technische Universität Berlin, Germany) "Peptide Antibiotics from Pathogenic Microorganisms - Structure, Biosynthesis and Engineering" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Mohamed Marahiel (Philipps-Universität Marburg, Germany) "Insights into the Biosynthesis and Structural Diversity of Bacterial Lasso Peptides" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Richard Lewis (The University of Queensland, Australia) "Unique Defensive and Predatory Envenomation Strategies in Cone Snails" |
9:15 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Posttranslationally Modified Proteins and Conjugates |
| Discussion Leaders: Jeffery Kelly (The Scripps Research Institute, USA) and Geoffrey Wahl (The Salk Institute, USA) |
9:00 am - 9:25 am | Hilal Lashuel (École Polytechnique Fédérale de Lausanne, Switzerland) "Posttranslational Modifications in Neurodegenerative Disease" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Matthew Pratt (University of Southern California, USA) "Investigating the Side-Specific Effects of Posttranslational Modifications with Protein Chemistry" |
10:05 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Christian Becker (University of Vienna, Austria) "Semisynthesis of Posttranslationally Modified Proteins" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Jianmin Gao (Boston College, USA) "Application of Iminoboronate Chemistry in Targeting Biomolecules and Peptide Cyclization" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Jennifer Stockdill (Wayne State University, USA) "Progress Toward a Universal Strategy for the Controlled Folding of Disulfide-Rich Peptides" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Joshua Price (Brigham Young University, USA) "Predictive Structure-Based Guidelines for Identifying Optimal Protein PEGylation Sites" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Peptides in the Immune System |
| Discussion Leaders: Charles Deber (University of Toronto, Canada) and Thomas Nielsen (Novo Nordisk, Denmark) |
7:30 pm - 7:55 pm | Huib Ovaa (The Netherlands Cancer Institute, The Netherlands) "Chemistry of MHC Class I Antigen Presentation" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Dana Ault-Riche (Reflexion Pharmaceuticals, USA) "Immunological Evaluation of Mirror Image Protein Therapeutics" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Michael Chorev (Harvard Medical School, USA) "Glycated CD59: A Novel, Disease Relevant Biomarker in Diabetes" |
9:15 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Critical Analysis of Cell Penetrating
Peptides |
| Discussion Leader: Joel Schneider (National Cancer Institute, NIH, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader: Critical Analysis of Cell Penetrating Peptides |
9:10 am - 9:35 am | Niels Geijsen (Hubrecht Institute, The Netherlands) "iTOP, a Novel Method for the Intracellular Delivery of Native Proteins" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Loren Walensky (Dana-Farber Cancer Institute, USA) "Biophysical Determinants for Cellular Uptake of Hydrocarbon-Stapled Peptides" |
10:15 am - 10:30 am | Discussion |
10:30 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Dehua Pei (The Ohio State University, USA) "Drugging Undruggable Targets with Macrocycles" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Yao-Cheng Leo Li (The Salk Institute for Biological Studies, USA) "ReBiL, a Powerful Platform Technology for Detecting Protein-Protein Interactions and for Identifying Specific Antagonists" |
11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Henry Herce (Technische Universitat Darmstadt, Germany) "Drugs Design and Delivery Using Cell-Penetrating Peptides: A Journey from Molecular Mechanisms to In Vivo Applications" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Peptide Vaccines |
| Discussion Leaders: Peter Kim (Stanford University School of Medicine, USA) and Michael Kay (University of Utah, USA) |
7:30 pm - 7:55 pm | Elisabetta Bianchi (IRBM Science Park S.p.A., Italy) "Strategies for the Development of Effective Peptide Vaccines" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Michael Zwick (The Scripps Research Institute, USA) "Recognition Requirements of Membrane-Proximal 'Linear' Epitopes on HIV-1 gp41" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Regan Anderson (Victoria University of Wellington, New Zealand) "Synthetic Peptide Vaccines Based on Glycolipid-Peptide Conjugates" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Jonathan Lai (Albert Einstein College of Medicine, USA) "Engineered Dengue Virus EDIIIs as Immunogen (Vaccine) Candidates" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Peptides in Epigenetic Regulation |
| Discussion Leaders: Dewey McCafferty (Duke University, USA) and Christian Adam Olsen (University of Copenhagen, Denmark) |
9:00 am - 9:25 am | Champak Chatterjee (University of Washington, USA) "Learning the Language of Histone Modifications with Semisynthetic Tools" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Danica Fujimori (University of California, San Francisco, USA) "Crossttalk Between Chromatin Reader and Eraser Domains in Histone Demethylases" |
10:05 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Beat Fierz (École Polytechnique Fédérale de Lausanne, Switzerland) "Probing the Dynamic Function of Histone PTMs, One Molecule at a Time" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Daniel Baxter (University of Bath, United Kingdom) "Cell-Permeable Helix-Constrained Peptides Inhibit Activator Protein-1 and Reduce Cancer Cell Viability" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Brian Strahl (University of North Carolina, USA) "Using Peptide Arrays to Uncover New Insights into Chromatin Regulation" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Intelligent Materials and Nanoparticles |
| Discussion Leaders: Jennifer Cochran (Stanford University, USA) and James Nowick (University of California, Irvine, USA) |
7:30 pm - 7:55 pm | Nicole Steinmetz (Case Western Reserve University School of Medicine, USA) "Virus Based Therapeutics and Contrast Agents" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Kamaljit Kaur (University of Alberta, Canada) "Microcantilever Arrays Functionalized with a Breast Cancer Targeting Peptide as Detection Platforms for Circulating Tumor Cells" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Annelise Barron (Stanford University, USA) "Deceptively Simple? Peptides that Form Toxin-Antitoxin Complexes" |
9:15 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |