Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Peptide Engineering and Biology
7:40 pm - 8:20 pm
"How Do Hsp70 Molecular Chaperones Recognize Their Client Proteins? The Molecular Origins of 'Promiscuous Selectivity'"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"Peptide-Polymer Conjugates for Therapeutic DNA Delivery"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chemical Biology of Peptides
9:00 am - 9:25 am
"New Strategies for Selective Recognition and Sensing of Post-Translational Modifications in Histone Peptides"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Customizing Macromolecules Through Chemical Ligation"
10:05 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Utilizing Peptide-Based Tools to Investigate Cell-Cell Communication in Bacteria"
11:15 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Machine Learning-Enabled Design of Cell-Penetrating Peptides"
11:45 am - 11:50 am
Discussion
11:50 am - 12:15 pm
"Facile Biocatalytic Synthesis of Hydroxylated Non-Canonical Amino Acids"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:55 pm
"Hierarchical Assembly of Collagen and Coiled Coil Peptide Motifs for Regenerative Medicine"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Engineering Peptide-Based Complex Coacervates for Therapeutic Delivery"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Exploiting Peptides to Overcome Barriers in Nanomedicine and Drug Delivery"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:25 am
"The Supramolecular Chemistry of the Antibiotic Teixobactin"
9:25 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Anti-HIV-1 Activity and Mode of Action of a Viral-Derived and Proteolysis-Resistant Peptide CXCR4 Antagonist"
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:55 am
"Targeting Huntingtin Misfolding Using Conformationally Specific Binders: Implications for Therapy and Biomarker Development in Huntington's Disease"
10:55 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Neuronal Imaging with Selective Nav1.7 Targeted Peptides"
11:35 am - 11:50 am
Discussion
11:50 am - 12:15 pm
"Structure Based Design Targeting the The Neuropeptide Receptor RXFP3"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Computational Peptide Design
7:30 pm - 7:55 pm
"Computational Peptide Design for Targeted Therapeutics"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Enhanced Sampling of Peptide Hairpin Loops to Map out Unusual Folds and Functions"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Experimentally-Constrained Computational Models for Studying Dynamic Proteins and Designing Synthetic Peptides"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Peptide Libraries and Lead Discovery
9:00 am - 9:25 am
"Laying the Foundation for Performing Drug Discovery on the Yeast Surface"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Directed Evolution of Cyclic Peptides for Inhibition of Autophagy in Ovarian Cancer"
10:05 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Stabilization of 14-3-3 Protein-Protein Interactions as a Drug Discovery Strategy"
11:15 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Phage Display Selection of Peptides that Resist Proteases in the Gastrointestinal Tract"
11:45 am - 11:50 am
Discussion
11:50 am - 12:15 pm
"Displayable Pseudo-Natural Products"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Peptide Therapeutics: From Clinical Trials to Market
7:30 pm - 7:55 pm
"Recent Developments and Insights in the Discovery of GLP-1/Glucagon Agonists for the Treatment of Diabetes and Obesity"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Illustrations of Harnessing Intrinsic Properties of Peptides for Therapeutic Benefits with Discovery and Development of Macimorelin and ALRN-6924"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Developing Peptides into Drugs for Intracellular Targets: Lessons Learned from p53/MDMX"
9:15 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Peptide Chemistry, Synthesis and Biosynthesis
9:00 am - 9:25 am
"Synthetic Biology Approaches to Bioorthogonal Chemistry"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Selenium as a Tool for Chemical Synthesis and Folding of Proteins"
10:05 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Self-Assembled Hybrid Collagen/Cell Penetrating Peptides in Drug Delivery Applications"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Chemical Tools Selective Recognition of Posttranslational Modifications"
11:35 am - 11:50 am
Discussion
11:50 am - 12:15 pm
"Genome Mining of Fungal Nonribosomal Peptides"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Peptide Pathologies and Vaccines
7:30 pm - 7:55 pm
"Immunogenicity of Peptide Drugs and Their Impurities: Taspoglutide Case Study"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Chemical Functionality of Multidomain Peptide Hydrogels Governs Early Host Immune Responses"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Activity-Based Probes with Unnatural Amino Acids to Monitor the Proteasome in Live Cells"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure