Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Peptide Chemistry and Pharmacology
7:40 pm - 8:20 pm
"Chemical Optimization of Endocrine Hormones To Transform Human Health"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Peptide Synthesis and Modification
9:00 am - 9:20 am
"Biosynthesis of Macrocyclic Peptides"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Chemical Tools to Uncover Hidden Proteomes"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Precision Tools for Peptide and Protein Engineering"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Chemoselectivity and Simplicity in Peptide Synthesis and Modification"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Photochemical Reactions for Complex Biological Environments"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Synthesis of Thioaminoketal-Containing Antimicrobial Peptides"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Late-Breaking Topic
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Delivery to Tissues and Cells
7:30 pm - 7:50 pm
"Peptide-Conjugates and Additives for Intracellular Protein Delivery"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Dynamic Membrane Permeabilization for Intracellular Protein Delivery"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Designing Cell Permeable Macrocycles and Peptides, Novel Approaches on the Horizon"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Chemical Biology Approaches for Measuring Intracellular Drug Delivery"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Peptides Progressing Toward the Clinic
9:00 am - 9:20 am
"Eloralintide - A Selective Amylin Receptor Agonist - Discovery and Early Clinical Development for People with Obesity"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Turning Data-Driven Peptide Discovery into Clinical Reality"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Platforms for the Intracellular Generation and High-Throughput Screening of Cyclic Peptide Libraries"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Discovery of AZD6234, a Selective Amylin Receptor Agonist Peptide"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"The Largest Small Molecule: Manufacturing Process for Enlicitide"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Stabilized (Neuro)Peptide Analogs to Target Kappa Opioid Receptors in Peripheral and Inflammatory Pain"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Biomimetic Peptide Materials
7:30 pm - 7:50 pm
"Conjugation Strategies and Medical Applications of Protein-Polymer Conjugates"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Backbone Expansion of Peptides and Proteins via Enzymatic Side Chain Transfer"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Mimicking Protein Structures with Peptide-Polymer Assemblies"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Engineering Peptides for Vaccines and Cancer Immunotherapy"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Structural and Functional Mimicry of Proteins
9:00 am - 9:20 am
"Application of Site-specific Backbone Alteration to Understand and Control Protein Folding Physics"
9:20 am - 9:30 am
Discussion
9:30 am - 9:45 am
"Doppelgänger Peptides: Molecular Mimics of Hormones as Scaffolds for Drug Discovery"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Programmable Biosynthesis of Unnatural Macrocyclic Peptides"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Tailored Synthetic Peptides – From Structure to Function"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Molecular Design, and Small Molecule Induced Repair of Peptide Therapeutics"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Mild Macrocyclization: New Chemoselective Approaches to Cyclic Peptides"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Machine Learning and Computational Design
7:30 pm - 7:50 pm
"Enhancing Peptide Developability with Machine Learning: Bridging Discovery and Development"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Screens and Models for Mapping Peptide Interaction Specificity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Closing the Loop on Designing Macrocycles"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Advancing Computational Tools for Enhanced Design and Characterization of Cyclic Peptides and Beyond"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Elucidating Biology with Peptide Tools
9:00 am - 9:20 am
"Next-Generation Approaches for Cell-Selective Nascent Proteomics"
9:20 am - 9:30 am
Discussion
9:30 am - 9:45 am
"Phage-Assisted Continuous Selection of Cyclic Peptide Protein Aggregation Inhibitors"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Precise Post-Translational Editing of Proteins via Chemically-Induced Proximity"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Bioconjugation of Aromatic Amino Acid Residues in Nonaqueous, Polypeptide-Compatible Media"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Covalent Cyclic Peptide Probes"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Posttranslational Modifications of Disordered Proteins"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Chemistry and Biology of Cyclic Imide Modifications in Regulating Protein Homeostasis"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Peptides at the Nexus of Proteostasis and Catalysis
7:30 pm - 8:10 pm
"Protein-Peptide Interactions in the Chaperone Network Shape Proteostasis"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 9:05 pm
"Minimalism: Catalysis by a Peptide and Metabolite in a Cell"
9:05 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure