Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Peptide Discovery Platforms
Discussion Leaders: Isaac Knudson (UC Berkeley, United States) and Estefania Martinez Valdivia (University of Michigan Ann Arbor, United States)
3:45 pm - 4:20 pm
Scott Lokey (University of California, Santa Cruz, United States)
"High-Throughout Discovery of Membrane Permeable Macrocyclic Peptides as Next-Generation Therapeutics"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Peptide Chemistry and Synthesis
Discussion Leaders: Elyse Williams (University of Zurich, Switzerland) and Michael Quagliata (University of Florence, Italy)
7:30 pm - 7:45 pm
Roshni Malde (Imperial College London, United Kingdom)
"Novel Quantitative Methodology for Studying Inhibition of Protein-Protein Interactions"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Philippe Nashar (The Australian National University, Australia)
"Late-Stage Modification of Peptides via Strain Release of [1.1.1]Propellane"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Lorenzo Pacini (University of Florence, Interdepartmental Research Unit of Peptide and Protein Chemistry and Biology, Italy)
"Eco-Friendly Binary Solvent Systems with Induction Heating on an Automated Peptide Synthesizer: Synthesis and HPLC-Free Purification of ß-Amyloid (1-42) and RBM of Sara CoV 2 Spike Protein"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Jacob Byerly-Duke (Iowa State University, United States)
"Thioimidate Solutions to Thioamide Problems: Improving the Solid Phase Synthesis of Thionopeptides"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Damla Surmeli (Tufts University, United States)
"Tuning Multi-Agonist Activation Using N-Terminal Modifications"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Steven Draper (University of Utah, United States)
"BOSS: Biotin Orthogonal Streptavidin System"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Peptide Therapeutics and Biological Systems
Discussion Leaders: Timothy Craven (Insamo, United States) and Alec Brennan (University of Nevada, Reno, United States)
9:00 am - 9:15 am
Franco Faucher (Stanford, United States)
"Selective Substrate Identification Using Chemically Modified Phage Display"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Shelley He (University of Toronto, Canada)
"Interactions of Designed Cationic Antimicrobial Peptides with the Outer Membrane of Gram-Negative Bacteria"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Ryan Moreira (University of Illinois Urbana-Champaign, United States)
"Action Mechanism of Enterococcal Cytolysin"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Tristan McPhail (University of Southern California, United States)
"Directed Evolution of Peptide-Based Diagnostics for Huntington's Disease"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Kendal Carrow (Northwestern University, United States)
"Proteomimetic Polymers for Modulating the Keap1/Nrf2 Protein-Protein Interaction"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Madeline Zoltek (University of California, Berkeley, United States)
"Design Rules for Efficient Endosomal Escape"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Peptide Materials, Tools, and Applications
Discussion Leaders: Nabanita Mukherjee (Indian Institute of Technology Jodhpur, India) and Hoang Truong (University of California, Santa Barbara, United States)
1:30 pm - 1:45 pm
Katherine Albanese (University of Bristol, United Kingdom)
"Self-Assembling De Novo Coiled-Coil Protein Modules for Membrane Remodeling"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Zijun Gao (Northwestern University, United States)
"Trehalose-Conjugated Peptide Amphiphiles Disrupt Amyloid Beta Aggregation and Enhance Neuron Survival"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
Zichen Liu (University of Virginia, United States)
"Measurement of Small Molecule Permeation into Mycobacteria with Stem Peptide Probes"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes