| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Recent Advances in (Tetra)Pyrrole Structure/Function |
| Discussion Leader: Andrew Munro (University of Manchester) |
| 7:40 pm - 8:10 pm | C.S. Raman (University of Maryland)
"Catalytic Repurposing of Heme Protein Scaffolds by Exaptation of Conformational States"
|
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:45 pm | Nicole Frankenberg-Dinkel (Ruhr- University Bochum)
"Biosynthesis and Assembly of Unusual Phycobiliproteins"
|
| 8:45 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:20 pm | Alison Thompson (Dalhouise University)
"Synthetic Strategies Towards Di- and Tripyrrolic Materials and Pharmaceuticals"
|
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Making and Breaking Tetrapyrroles |
| Discussion Leader: Jennifer Dubois (Montana State) |
| 9:00 am - 9:30 am | Bernhard Krautler (University of Innsbruck)
"News on Phyllobilins - The Bilin-Type Chlorophyll Catabolites"
|
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Michi Taga (UC Berkeley)
"Shared Tetrapyrrole Biosynthesis in Microbial Communities"
|
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | Wolfgang Schoefberger (Johannes Kepler University)
"Chemical Synthesis and Characterization of High-Valent Metal Tetrapyrrolics for Catalysis and Biomedical Applications"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Angela Wilks (University of Maryland)
"The Dark Side of Heme Utilization in P. aeruginosa"
|
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Evelyne Deery (University of Kent)
"Genetically Reprogramming E. coli as a Cobalamin (Vitamin B12) Producer" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Tetrapyrroles Involved in Signalling and Sensing |
| Discussion Leader: Peter Meissner (University of Cape Town) |
| 7:30 pm - 8:00 pm | Bob Kranz (Washington University in St. Louis)
"Cytochrome C Biogenesis: Heme Trafficking, Redox Control, and Attachment"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Eric Skaar (Vanderbilt University)
"Heme Sensing, Synthesis, and Degradation in Bacterial Pathogens"
|
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Catherine Drennan (MIT)
"An Old Cofactor in a New Light: Adenosylcobalamin in Light-Dependent Gene Regulation"
|
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Metals and Tetrapyrroles |
| Discussion Leader: Dieter Jahn (Technical University Braunschweig) |
| 9:00 am - 9:30 am | Mark O'Brian (State University of New York at Buffalo)
"Coordinated Response to Metabolic Stress by Heme-Dependent Gene Expression"
|
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Syun-Ru Yeh (Albert Einstein College of Medicine)
"Tryptophan Dioxygenase: Catalytic Mechanism and Allosteric Regulation"
|
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | Harry Dailey (University of Georgia)
"Terminal Enzymes of Heme Synthesis, New Functions for Old Enzymes and New Enzymes with Unique Abilities"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Wilhem Boland (Max Planck Institute for Chemical Ecology)
"Chlorophyll Digestion and Function in the Insect Gut"
|
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Makiko Yasuda (Mount Sinai)
"RNAi-Mediated Inhibition of Hepatic Alas1 Effectively Prevents and Treats the Induced Acute Attacks in Acute Intermittent Porphyria Mice" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Evolution of the Cofactors of Life |
| Discussion Leader: Stuart Ferguson (University of Oxford) |
| 7:30 pm - 8:00 pm | Clark Lagarias (UC Davis)
"Bilin-Based Light Sensor Evolution"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Jonathan Lindsey (North Carolina State University)
"A Chemical Model for the Prebiogenesis of Tetrapyrrole Macrocycles and the Origin of Photoactive Protocells"
|
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Alison Smith (University of Cambridge)
"Evolution of B12 Auxotrophy and Its Role in Signalling Between Organisms" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Tetrapyrroles in Health and Disease |
| Discussion Leader: Celia Goulding (UC Irvine) |
| 9:00 am - 9:30 am | Jean-Charles Deybach (Hôpital Louis-Mourier, Paris)
"Acute Intermittent Porphyria Causes Hepatic Mitochondrial Energetic Failure (TCA Cycle Cataplerosis) from Mouse Studies to Human Disease"
|
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Helga Refsum (University of Oslo)
"Vitamin B12 and Dementia"
|
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | Bill Querbes (Alnylam)
"Development of ALN-AS1, a RNAi Therapeutic for the Treatment of the Hepatic Porphyrias"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Tim Egan (University of Cape Town)
"New Chemical Approaches to Probing the Effects of Antimalarials on Heme Concentrations in the Malaria Parasite"
|
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Angela Fleischhacker (University of Michigan)
"Reduction of a Disulfide Bond in Human Heme Oxygenase-2 Reveals a Second Heme Binding Site" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 7:30 pm - 9:30 pm | Delivery, Repair And Change Of Activity |
| Discussion Leader: Gloria Ferreira (University of South Florida) |
| 7:30 pm - 8:00 pm | Ruma Banerjee (University of Michigan)
"The Enzymology of B12 Trafficking"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Iqbal Hamza (University of Maryland)
"Control of Organismal Heme Homeostasis"
|
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Josef Komenda (Academy of Sciences, Czech Republic)
"Delivery of Chlorophyll to Photosystem II During Assembly and Repair"
|
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Tetrapyrroles in Applied and Synthetic Biology |
| Discussion Leader: Mark Shepherd (University of Kent) |
| 9:00 am - 9:30 am | Joseph Hupp (Northwestern University)
"Porphyrinic Metal-Organic Framework Materials"
|
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Ross Anderson (University of Bristol)
"Constructing Man-Made C-Type Cytochromes for Biological Integration"
|
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | Emma Raven (University of Leicester)
"Heme Versatility - From Catalysis to Regulation"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Steve Ragsdale (University of Michigan)
"Anaerobic Methane Metabolism and Biotechnological Applications"
|
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | David Leys (University of Manchester)
"Reductive Dehalogenase Structure Suggests a Mechanism for B12-Dependent Dehalogenation" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Paradigm Shifts In Tetrapyrrole Biology |
| Discussion Leader: Matthew Terry (University of Southampton) |
| 7:30 pm - 8:20 pm | Masao Ikeda-Saito (Tohoku University)
"Two Distinct Heme Degradation Enzymes; The Heme Oxygenase and the IsdG-type Enzymes"
|
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 9:20 pm | Neil Hunter (University of Sheffield)
"Photons to ATP: How Chlorophyll-Proteins Are Made, What They Do for Living, and How We Might Put Them to New Uses"
|
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |