Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Tetrapyrroles: Chemistry and Catalysis
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
"Coordination and Electronic Structures of Short-Lived Intermediate in Heme-Containing NO Reductases"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Unraveling the Chemistry of Reversible Heme Binding"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Unusual Heme Binding and Its Functional Significance in Heme-Regulated Proteins"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Heme Synthesis and Pathophysiology
9:00 am - 9:25 am
"ALA Synthases and Their Substrates: The Heme Gatekeepers"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"RNAi Therapeutics for Acute Hepatic Porphyrias"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Adaptive Responses to Heme-Induced Neuronal Stress: SEeing Is Believing"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"FAM210B Is an Erythropoietin Target and Regulates Erythroid Heme Synthesis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"TNGO-2 Regulates Cellular Heme Homeostasis in Metazoa"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regulatory Pathways in Chlorophyll and Energy Production
7:30 pm - 7:55 pm
"Multiple Posttranslational Control Mechanisms on Glutamyl-tRNA Reductase"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Regulation of Chlorophyll Metabolism by Mg-Dechelatase"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Redox and Light Control of Tetrapyrrole Synthesis in an Anoxygenic Phototroph"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Bridging the Gap: How Magnesium Chelatase Harnesses ATP Hydrolysis to Power Metal Ion Insertion"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Heme Trafficking and Imaging
9:00 am - 9:25 am
"Heme Trafficking and Modification in Cytochrome c Biogenesis"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Heme Gazing: Elucidating Heme Trafficking and Signaling with Fluorescent Heme Sensors and Affinity Reagents"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"Quantifying Heme Levels in Malarial Parasites Through Imaging"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Label-Free Transient Absorption Imaging of Heme Storage, Transport, and Modifications"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Heme Transport and Recycling "
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The Heme Regulatory Motifs of Heme Oxygenase-2 Function to Transfer Heme to the Catalytic Site for Degradation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"GAPDH Regulates Allocation of Bioavailable Heme in Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Linear Tetrapyrroles and Photoreceptors
7:30 pm - 7:55 pm
"Life on the (Far)-Red-Edge of Darkness: How Terretrial Cyanobacteria Sense and Respond to Far-Red Light"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Functional Diversification of Two Bilin Reductases for Photoperception and Photosynthesis in a Unique Cyanobacterium Acaryochloris marina "
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Type IV Chromatic Acclimation in Marine Synechococcus "
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Spectroscopic Evidence for Electronic Control of Heme Hydroxylation by IsdG"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Biosynthesis, Trafficking and Homeostasis of B12 and Corrinoids
9:00 am - 9:25 am
"The Partitioning of Metals in Tetrapyrrole Biosynthesis"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Cofactor Specificity in Corrinoid-Dependent Bacteria"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"B12 Trafficking and Its Modulation by Itaconate"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Elucidating the Mechanistic Underpinnings of Cobalamin in Microbial Cell Growth, Gene Regulation, and Enzyme Activity"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Cobalamins for Biomimetic Studies and Medicinal Applications"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Structure of Human Aminolevulinate Synthase Reveals a Strong Evolutionary Divergence in C-Terminal Regulation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Investigating the Molecular Basis of Vitamin B12 Uptake in Algae"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Tetrapyrroles: Degradation and Signaling
7:30 pm - 7:55 pm
"Discovery of NO-Responsive Hemoproteins and Their Roles in Biofilm Regulation"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Near-Infrared Fluorescent Proteins, Biosensors and Optogenetic Tools Engineered from Bacterial Phytochromes"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Heme, Bile Bigments and Beyond: Bilirubin Oxidation Products and Liver Function Under Stress Conditions"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"The Extracellular Heme Sensor HasAp Is Central to Heme Metabolism and Virulence"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Tetrapyrroles at the Host-Pathogen Interface
9:00 am - 9:25 am
"Heme-Induced Cell Signaling in Aedes aegypti "
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Porphyrin Trafficking and Metabolism in Trypanosomatid Protozoan Parasites"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"Impact of Heme in the Host-Pathogen Relationship"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Heme Utilization by Blood-Stage Malaria Parasites"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Neutron Structure of a Peroxidase-Substrate Complex Reveals Neutral Arginine in Proton Pathway"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Structural Investigation of Determinants Mediating ALAS Cofactor Binding"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Toxoplasma gondii , an Obligate Intracellular Protozoan Pathogen, Relies on Its own Heme Biosynthesis for Infection"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Tetrapyrrole Homeostasis: From Microbes to Man
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:15 pm
"Macrocyclic Tetrapyrroles: The 72 Steps to the Pigments of Life"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 8:35 pm
Introduction by Discussion Leader
8:35 pm - 9:15 pm
"Biological Lessons from Patients with Inherited Disorders of Cobalamin Metabolism"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure