| SUNDAY |
| 2:00-9:00pm | Arrival and Registration |
| 6pm | Dinner |
| Keynote Speaker |
| 7:30pm | R. Kramer (BMS)
Welcome and Introduction |
| 7:45pm | Frank McCormick (USCF)
"Cancer Therapy Based on Ras, Rb and p53" |
| MONDAY |
| 7:30-8:30am | Breakfast |
| 8:35am | GRC Business |
| Cancer Pharmacogenomics |
| 8:45am | Chair: Nic Dracopoli (BMS)
"Pharmacogenomic Applications in Oncology Drug Development" |
| 9:00am | William Gerald (MSKCC)
"Alterations in Gene Expression during Androgen Ablation Therapy of Prostate Carcinoma" |
| 9:35am | Discussion |
| 10:00am | Picture and Coffee Break |
| 10:30am | Todd Golub (Dana-Farber)
"Gene Expression Signatures of Cancer" |
| 11:05am | Discussion |
| 11:30am | Jeffrey Trent (NIH)
"Genome-Wide Views of Cancer Using Expression Profiling" |
| 12:05am | Discussion |
| 12:30pm | Lunch |
| 4:30pm | POSTER SESSIONS |
| 6:00pm | Dinner |
| Tumor Host Interactions - Therapeutic Implications |
| 7:30pm | Chair: Beverly Teicher (Genzyme Corp)
"Exploring the Role of Tumor Physiology and Stromal Interactions in Therapeutic Response" |
| 7:45pm | Lisa Coussens (UCSF)
"Deconstructing the Matrix: MMPs and their Substrates Regulate Epithelial Carcinogenesis" |
| 8:20pm | Discussion |
| 8:45pm | Jeffrey Arbeit (UCSF)
"Induction of Quiescent Hypervascularity by Gain of Epithelial HIF-la Function" |
| 9:20pm | Discussion |
| TUESDAY |
| 7:30-8:30am | Breakfast |
| Prostate Cancer |
| 8:45am | Chair: Marco Gottardis (BMS)
"Use of AR Molecular and Structural Biology cues to Design New Endocrine Therapies for Prostate Cancer" |
| 9:00am | Howard Scher (MSKCC)
"Targeting the Androgen Receptor Signaling Axis in Castration Resistant Disease" |
| 9:35am | Discussion |
| 10:00am | Coffee Break |
| 10:30am | John Isaacs (Bunting-Blaustein)
"Using the Biology of Prostate Cancer to Develop Targeted Therapy" |
| 11:05am | Discussion |
| 11:30am | Peter Nelson (Fred Hutchinson Cancer Research Ctr)
"Utilizing the Prostate Transriptome to Characterize Mechanisms of Complementary and Alternative Prostate Cancer Therapies" |
| 12:05am | Discussion |
| 12:30pm | Lunch |
| 4:30pm | POSTER SESSIONS |
| 6:00pm | Dinner |
| Growth Factor Receptors and Kinase Inhibitors |
| 7:30pm | Chair: Edward Sausville (NCI) |
| 7:45pm | Jose Baselga (Vall d'Hebron University Hospital)
"Targeting the Epidermal Growth Factor Receptor Family: Current Status and Challenges" |
| 8:20pm | Discussion |
| 8:45pm | Pamela Trail (Bayer)
"Development of the Raf Kinase Inhibitor BAY-439006 for the Treatment of Cancer" |
| 9:20pm | Discussion |
| WEDNESDAY |
| 7:30-8:30am | Breakfast |
| Targeting Tumor Suppressors |
| 8:45am | Chair: Michael Morin (Pfizer)
"Therapies Targeting Tumor Suppressor Genes: Small Molecules, Big Viruses and the Space in Between" |
| 9:00am | William Kaelin (Dana Farber)
"Therapeutic Approaches Based on Inactivation of Tumor Suppressor Genes: Lessons from RB1 and VHL" |
| 9:35am | Discussion |
| 10:00am | Nominations for Vice Chair for 2003
Coffee Break |
| 10:30am | Geoff Duyk (Exelixis)
"Genetic Analysis of Tumor Suppressor Pathways: The Role of Pathway Analysis and Drug Discovery" |
| 11:05am | Discussion |
| 12:30pm | Lunch |
| 4:30pm | POSTER SESSIONS |
| 6:00pm | Dinner |
| Tubulin and Motor Proteins |
| 7:30pm | Chair: Ken Tew (Fox Chase) |
| 7:45pm | Kenneth Wood (Cytokinetics)
"Mitotic Kinesin-Targeted Antitumor Agents" |
| 8:20pm | Discussion |
| 8:45pm | Paraskevi Giannakakou (Emory)
"Role of Microtubules in p53 Intracellular Trafficking and Signaling: Therapeutic Implications" |
| 9:20pm | Discussion |
| THURSDAY |
| 7:30-8:30am | Breakfast |
| Targeting Chaperones and the Cell Cycle |
| 8:45am | Chair: Kevin Webster (Aztra Zeneca) |
| 9:00am | Philipp Steiner (Millenium)
"Proteasome Inhibition to Treat Cancer: Development of PS-341" |
| 9:35am | Discussion |
| 10:00am | Election of Vice Chair for 2003
Coffee Break |
| 10:30am | Neal Rosen (MSKCC)
"The Hsp90 chaperone as a regulator of mitogenic signaling and potential therapeutic target for cancer" |
| 11:05am | Discussion |
| 11:30am | Nikolai Pavletich (MSKCC)
"Ubiquitin-ligases in Cancer: a Structural Perspective" |
| 12:05am | Discussion |
| 12:30pm | Lunch |
| 1:30pm | PROGRAM COMMITTEE, Year 2003 Conference |
| 4:30pm | Presentation of Selected Posters |
| 6:00pm | Banquet |
| Regulatory Challenges for the Cancer Drugs of Tomorrow |
| 7:30pm | Chair: Susan Arbuck (BMS) |
| 7:45pm | Richard Pazdur (FDA)
"Drug Regulations: Defining Success in a Changing Scientific Environment" |
| 8:20pm | Discussion |
| 8:45pm | Craig Henderson (UCSF)
"Regulators and Drug Developers: Creation of a Collegial Partnership for the War on Cancer" |
| 9:20pm | Discussion |
| BOOGIE NIGHT |
| FRIDAY |
| 7:30-8:30 | Breakfast |
| 9:00 | Conferees depart |
