Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Cilia,
Mucus and Mucociliary Diseases
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Airway Mucus Production, Secretion, and Function"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Airway Mucus in the Pathogenesis and as a Therapeutic Target of Chronic Lung Diseases"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Cryo-Electron Tomography Reveals How Cilia and Flagella Generate Motility"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Differentiation,
Assembly, and Regulation of Mucociliary Components
9:00 am - 9:20 am
"Themes and Variations in Centrosome and Cilia Structure and Function in Development and Evolution"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"A Bioactive Peptide Amidating Enzyme Is Required for Ciliogenesis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Contribution of Cilia to Mucociliary Defects in Pulmonary Fibrosis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"The X-Linked Inheritance in PCD: Discovery of a New Causative Gene"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Ida3 Is a Novel Inner Dynein Arm Assembly Factor that Is Transported by IFT in Growing Cilia"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"A New, Highly Conserved GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Technical
Advancements to Study Mucociliary Biology
7:30 pm - 7:50 pm
"New Insights Using Functional Anatomic Imaging to Interrogate the Airway Surface"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Probing Microbial Interactions with the Mucus Barrier"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Mucoinflammatory Bronchiectasis in Cystic Fibrosis Ferrets Does Not Require Infection"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Matching Mucus to Cilia"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mucociliary Dysfunction: Balancing Homeostasis and Pathophysiology
Session in memory of Mary Rose.
9:00 am - 9:20 am
"Mechanisms
for Acquired and Genetic Motile Ciliopathies"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Modeling the Complex Genetics of Ciliopathy in Mice"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Mucociliary Function in the Fallopian Tube"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"P. aeruginosa Inhibits CFTR Cl Secretion by Human Airway Epithelial Cells"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Determinants of Mucociliary Transport in CF Airways"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Regulation of Cilia Function by Selective Autophagy in Lung Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Protein Assembly and
Glycosylation
7:30 pm - 7:50 pm
"Making Sense of Mucin O-Glycosylation: It's a Lot More Complicated than We Thought"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Transcriptional Regulation of Motile Ciliation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Conserved Complexes Regulating Dynein Assembly and Ciliary Waveform"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Functional Glycomics of Mucins"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mucociliary Defense
and Immunity
9:00 am - 9:20 am
"Mucin Sialylation Regulates Eosinophilic Airways Inflammation via Siglec Engagment"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Understanding Cytokine Regulation of Cellular Stress in Infectious and Inflammatory Disease at Mucosal Surfaces"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"New Roles for Goblet Cells in Immunity"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Interactions Between Macrophages, Epithelial Cells, and Mucociliary Clearance Mechanisms"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Sentinel Goblet Cells: Goblet Cell-Mediated Mucosal Defense Beyond Mucus Layer Formation"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Regulation of Mucin Biosynthesis and Secretion"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Cellular and
Developmental Aspects of Cilia and Mucus Biology
7:30 pm - 7:50 pm
"Uncoupling Centriole Replication from the Cell Cycle in Multiciliated Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"The Role of Immotile Cilia in Sensing the Fluid Flow for Left-Right Patterning"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"miR-34/449 in Multiciliated Cells"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Regulation of Motile Ciliogenesis by microRNAs"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Understanding of Muco- and Ciliopathies
9:00 am - 9:20 am
"Biophysical Properties of MUC5B and MUC5AC Mucus in Health and Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"A Multi-System Approach to Define Regulatory Networks Necessary for Ciliary Motility"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Idiopathic Pulmonary Fibrosis: A Genetic Disease that Involves Mucociliary Dysfunction of the Peripheral Airways"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"The Molecular Toolbox for Building Axonemal Microtubules"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Genetic Heterogeneity in PCD: Efficiency and Limitations of NGS-Based Approaches"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Large Scale Approaches to Understand Cilia and Ciliopathies"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Therapeutic
Targets and Strategies for Disorders of Mucus and Cilia
7:30 pm - 7:50 pm
"Therapeutic Strategies to Enhance Cilia, Mucus, and Mucociliary Functions"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"iPS Cells for the Derivation of Motile Ciliated Cells and Applications for PCD and CF"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Mucus-Penetrating DNA Nanoparticles for Inhaled Gene Therapy"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Randomized Trials in PCD - Start of a New Era"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure