Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Cilia, Mucus and Mucociliary Interactions
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Cilia in Congenital Heart Disease"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Mucins: The Chief Components of Airway Mucus"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Mucociliary Interactions: Integrated Functions of Mucus and Cilia in Health and Disease"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genetics and Genomics of Cilia and Mucus Biology
9:00 am - 9:20 am
"Single Cell Sequencing to Investigate Multiciliogenesis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Pulmonary Fibrosis and MUC5B: Novel Insights into an Incurable Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Insights into the Genetics of PCD"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Airway Epithelial Reprogramming in Asthma"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Airway Epithelial Intelectin-1 Secretion Affects IL-13-Induced Mucus-Driven Airway Dysfunction and Expression of the Gene Is Regulated by an eQTL that Is Associated with Development of Asthma and IBD"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Transcriptomics of Airway Basal Cell Fate and Chronic Airway Disease"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Developmental and Gene Regulatory Determinants of Mucociliary Function
6:00 pm - 6:20 pm
"Notch Signaling in Mucociliary Fate Determination"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"The Regulation of MUC5B Expression by ER Stress Transcription Factor XBP1S"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Genetic Regulation of Motile Cilia Functions"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Bpifb1 Regulation of Muc5b"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Protein Assembly and Structure: Translating Messages to Build Mucins and Cilia
9:00 am - 9:20 am
"From 2 to 100: How Multiciliated Cells Amplify Centrioles"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Inositol Requiring Enzyme 1β: A Key Regulator of Airway Mucin Production"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"How Microtubules and Motors Interact for Cilia Functions"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Regulation of Protein Assembly and Function by Disulfide Catalysts"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"The C-Terminal Dimerisation Domain of Mucin MUC5B: Structure, Stability and Interactions"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Molecular Mechanisms Regulating Mucociliary Morphogenesis"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Trafficking and Transport of Mucociliary Components
6:00 pm - 6:20 pm
"Studies of Cilia and Intraflagellar Transport by 3D CryoEM"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Mucin Exocytic Mechanisms"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Regulation of Multiciliated Cell Dyneins"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"In Vivo Effects of Mucin Assembly on Mucociliary Functions"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell Biology of Cilia, Flow and Mucin Components
9:00 am - 9:20 am
"A Liquid-Like Organelle for Axonemal Dynein Assembly in Ciliated Cells"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"New Insights into IFT Regulated Transport of Axonemal Dyneins and Cilia Length"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Biochemical Changes in MUC5AC and MUC5B in Disease"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Noncanonical Wnt Signaling in Airway Epithelial Planar Polarization and Differentiation"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Bcl-2 Modifying Factor (Bmf) Reduces Goblet Cell Metaplasia by Enhancing Mucin Degradation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Controlling Centriole and Cilium Number in Olfactory Sensory Neurons"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Cilia-Based Flow Network in the Brain Ventricles"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Molecular Determinants of the Cilia-Fluid Interface and Extracellular Spaces
6:00 pm - 6:20 pm
"Innate Lymphoid Cell Anti-Helminth Defense via Mucins in Gut and Lungs"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Cilia Act as a Regulated Secretory Pathway for the Peptide Amidating Enzyme and Its Bioactive Products"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Single-Cell Genomics of Mucosal Barrier Tissues"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Ciliary Beating Compartmentalizes Cerebrospinal Fluid Flow in the Brain and Regulates Ventricular Development"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Mucus Biophysics: Determinants of Gel Size and Mobility"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
New Model Systems for Integration of Cilia and Mucus to Host Functions
9:00 am - 9:20 am
"Spatiotemporal Organization of Cilia Drives Mucus Mixing in Airway Epithelia"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"3D Bioengineering of Lung"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Global Techniques for Novel Mechanisms of Ciliary Signaling"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Network Analysis of Goblet Cell Formation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Novel Cilia Biosensor Tracking Single Cell Cycle Kinetics and Ciliary Cycle"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Translational Imaging Studies of Mucociliary Function and Dysfunction"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Implications of Mucociliary Biology to Health and Disease
6:00 pm - 6:20 pm
"RNA Replacement Therapy Approaches for Motile Cilia Disease"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Mitochondrial Adenine Nucleotide Translocase Influences Ciliary Function and Airway Homeostasis"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Mucus Obstruction in Asthma"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Clearing Lungs with ENaC Inhibition in Primary Ciliary Dyskinesia Trial"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Development and Deployment of Efficacious Mucolytic Therapies"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure