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Collagen

Gordon Research Conference

Collagens and Associated Molecules Supporting Organ Structure and Function

July 14 - 19, 2019

Chair

Vice Chair

Colby-Sawyer College

541 Main Street

New London, New Hampshire, United States

Venue and Travel Information

Conference Description

Currently, 28 different collagen types have been identified. The goal of the 2019 Collagen Gordon Conference is to disseminate information on the characteristics of these collagens and molecules they interact with that support the structure and function of tissues and organs. Also, errors in the collagen genes and proteins that result in dysfunction and disease will be discussed.

Related Meeting

This GRC will be held in conjunction with the "Collagen" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Keynote Session: LAMA2-Deficient Muscular Dystrophy / Skin Stem Cell Homeostasis and Regeneration Discussion Leader:
7:40 pm - 7:50 pm	Introduction by Discussion Leader
7:50 pm - 8:20 pm	"Linker Protein Repair of LAMA2-Deficient Muscular Dystrophy"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Gene Therapy for Epidermolysis Bullosa"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Efficient Genome Editing Using CRISPR/Cas9 Ribonucleoprotein Approach in iPS Cells for Recessive Dystrophic Epidermolysis Bullosa"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Analysis of Microfibril Architecture in Dystrophic Epidermolysis Bullosa Skin Reveals Novel Mechanisms of Fibrosis-Related Extracellular Matrix Assembly"
9:25 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Collagen Transport and Trafficking Discussion Leader:
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	"Mechanism of Collagen Secretion"
9:35 am - 9:45 am	Discussion
9:45 am - 10:05 am	"Procollagen Sorting at ER Exit Sites"
10:05 am - 10:15 am	Discussion
10:15 am - 10:25 am	"The Endocytic Collagen Receptor uPARAP/Endo180 as a Novel Therapeutic Target in Mesenchymal Cancers"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Circadian Clocks in Health and Disease of the Musculoskeletal System"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Intracellular Trafficking and Processing of Type I Procollagen"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Giantin Is Required for Intracellular N-Terminal Processing of Procollagen Type I"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"OASIS on the Move: Elucidation of the Molecular Cause Underlying CREB3L1-Related Osteogenesis Imperfecta"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Bioengineering for Repair of Function Discussion Leader:
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:00 pm	"Role of Exosomes on Corneal Wound Healing"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:30 pm	"Rebuilding the Matrix in a Crowded Milieu"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:00 pm	"The Use of Collagen Methacrylate in Actuating Polyethylene Glycol Diacrylate-Acrylic Acid Scaffolds for Muscle Regeneration"
9:00 pm - 9:10 pm	Discussion
9:10 pm - 9:20 pm	"Orienting Collagen In Situ as a Regenerative Scaffold for Neuronal Regrowth"
9:20 pm - 9:25 pm	Discussion
9:25 pm - 9:30 pm	General Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Treatment and Diagnosis of Matrix Diseases Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	"System Involvement in Epidermolysis Bullosa: Consequences for Evidence-Based Therapies"
9:30 am - 9:40 am	Discussion
9:40 am - 10:00 am	"A Case of Mechanistic Insights Defining Treatment and Diagnosis"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	"From the Bytes to the Bedside: The Role of Collagen XVIII in Normal and Malignant Hematopoiesis"
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Group Photo / Coffee Break
10:55 am - 11:15 am	"Basement Membrane Gene Defects Associate with an Increasing Spectrum of Kidney Disease"
11:15 am - 11:25 am	Discussion
11:25 am - 11:45 am	"Molecular Underpinnings of Collagen Interactions in the ECM in Health and Disease"
11:45 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"Aberrant Binding of Mutant HSP47 to Type I Collagen Results in Severe Osteogenesis Imperfecta"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:20 pm	"Somatic Mutations in Collagens Are Associated with Overall Survival and Impact Tumors"
12:20 pm - 12:25 pm	Discussion
12:25 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Cartilage and Bone Disease Discussion Leader:
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:00 pm	"Unraveling the Cell and Molecular Bases of Intervertebral Disc Degeneration"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:30 pm	"The Intersection of Types V and VI OI in Patients and Mice"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:00 pm	"Further Consideration of the Role of Matrix Metalloproteinase 13 in Matrix Diseases"
9:00 pm - 9:10 pm	Discussion
9:10 pm - 9:20 pm	"Cross-Linked Collagen Peptides as a Non-Invasive Urinary Biomarker of Bone Quality in Patients with Osteogenesis Imperfecta"
9:20 pm - 9:25 pm	Discussion
9:25 pm - 9:30 pm	General Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Collagens of the Basement Membrane Zone Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	"Halogens Are Essential for Building Collagen IV Smart Scaffolds"
9:30 am - 9:40 am	Discussion
9:40 am - 10:00 am	"Construction of a Basement Membrane Toolkit in C. elegans: Stoichometry, Turnover and Growth Revealed"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	"Collagen XVIII Regulates Nephron Progenitor Cell Fate and Is Crucial for Branching Morphogenesis During Kidney Development"
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:15 am	"Basement Membrane Zone Collagens in the Development and Function of the Zebrafish Neuromuscular System"
11:15 am - 11:25 am	Discussion
11:25 am - 11:45 am	"Therapeutic Implications of Tissue Specific Mechanistic Heterogeneity in COL4A1 Syndrome"
11:45 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"Material-Driven Fibronectin Assembly Affects Patient Cells Harbouring a Collagen IV Mutation"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:20 pm	"Modelling Alport Syndrome Using Patient-Derived iPSCs"
12:20 pm - 12:25 pm	Discussion
12:25 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	Wound Healing Discussion Leader:
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:00 pm	"Studying the Cornea to Understand Regenerative Repair"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:30 pm	"Collagen Composites for Tissue Engineering Applications"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:00 pm	"Gelatin Based Scaffolds and Injectable Substrates for Wound Healing"
9:00 pm - 9:10 pm	Discussion
9:10 pm - 9:20 pm	"Role of Type III Collagen in the Breast Cancer Microenvironment"
9:20 pm - 9:25 pm	Discussion
9:25 pm - 9:30 pm	General Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Mechanical Tissue Properties: Collagens in Aging Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	"Collagens in Aging Corneal Wound"
9:30 am - 9:40 am	Discussion
9:40 am - 10:00 am	"Mechanism of Collagen VI Microfibril Assembly Revealed by Cryo-Electron Microscopy"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	"Collagen Mechanics Investigated with Single-Molecule Techniques"
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:15 am	"Inhibiting Cell Senescence for Treating Injury and Aging Associated Osteoarthritis"
11:15 am - 11:25 am	Discussion
11:25 am - 11:45 am	"Matrix Microenvironment and Stem Cell Fate Determination"
11:45 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"Heterogeneously Strained Tissue Collagen Resists Collagenase Degradation Where Strains Are High"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:20 pm	"Chondrogenic Progenitor Cells Regulate Collagen Types I and II in the Regeneration of Cartilage Tissue"
12:20 pm - 12:25 pm	Discussion
12:25 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Modifications of Collagens Discussion Leader:
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:00 pm	"Key Collagen Synthesis Enzymes and ECM Homeostasis"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:30 pm	"Collagen Fibril Modifications for Function and in Pathology"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:00 pm	"Cell Metabolism Regulates Collagen Synthesis and Hydroxylation"
9:00 pm - 9:10 pm	Discussion
9:10 pm - 9:20 pm	"Re-Evaluation of Lysyl Hydroxylation in the Collagen Triple Helix Regarding Site Preference and Type Specific Activities"
9:20 pm - 9:25 pm	Discussion
9:25 pm - 9:30 pm	General Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Institute Of Arthritis And Musculoskeletal And Skin Diseases of the National Institutes of Health under Award Number R13AR074867. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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