Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Latest Updates in Skin Biology
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:20 pm
"Exploring the Transition from Stem Cell to Differentiated Cell in Human Epidermis"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:05 pm
"Stem Cell-Centric Mechanisms of Hair Follicle Aging"
9:05 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Ocular Surface and Lacrimal Gland
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Development of Causative Treatment Strategies for Lacrimal Gland Insufficiency by Tissue Engineering and Cell Therapy"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"PPAR Signaling Regulates Meibocyte Differentiation of Cultured Human Meibomian Gland Epithelial Cells (hMGEC)"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Effect of Intermittent Shear Stress on Corneal Epithelial Cells Using an In Vitro Flow Culture Model"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Neuronal Control of Lacrimal Gland Development and Regeneration"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Glycosylation Pathways in Ocular Surface Disease"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Pea3 Transcription Factors Determine the Lacrimal Gland Cell Fate"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Microbiology and Infectious Disease
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"The Host Immune Response to Corneal Infection: The Battle Between the Bug and the Body"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"The Continuing Challenge of Antibiotic Resistance in Corneal Infection"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Pseudomonas : Pathogenesis, Proteomics and Licorice"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"Development of Hypoxia and Prevalence of Glycolytic Metabolism in Herpes Stromal Keratitis Lesions"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Stromal Development, Disease and Therapy
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Developmental Dynamics of the Corneal Extracellular Matrix"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Combination Gene Therapy for Treating Corneal Scarring and Angiogenesis"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Periocular Neural Crest Differentiation into Corneal Cells Is Dependent on Cues from the Ocular Environment"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Corneal Myofibroblasts: Evidence of Differentiation from Adult Schwann Cells"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Small Leucine-Rich Repeat Proteoglycans of the ECM Regulate Innate and Adaptive Immunity"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Limbal Mesenchymal/Stromal Stem Cells: Role in Corneal Wound Healing and Regeneration"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Fibrocytes Migrate to the Cornea and Differentiate into Myofibroblasts During the Wound Healing Response to Injury"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Translational Research: In Search of New Therapies
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Corneal Stem Cells Mimicking In Vitro Niches"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Translational Research on Corneal Endothelial Regeneration"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"The Hair Follicle at the Center of Skin Regeneration"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Co-Ordinated Generation of Multiple Ocular-Like Cell Lineages and Fabrication of Functional Corneal Epithelial Cell Sheets from Human iPS Cells"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Innate and Acquired Immunity in Corneal Pathophysiology
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Loss and Restoration of Immune Regulatory Function in Corneal Inflammation"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Stem Cell Therapies for Efficient Treatment of Immune-Mediated Diseases of the Eye"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"SLURP1 Stabilizes HUVEC Barrier Function, Suppressing dHL-60 Neutrophil Binding, Transmigration and Chemotaxis"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Regulation of CD11c Positive Cells by TLR3 in the Cornea"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Contribution of Mast Cells in Non-Allergic Corneal Inflammation"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"The Role(s) for CD4+T Cell Subsets in Conjunctival Inflammation"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Virulence Determinants and Host Response During Pseudomonas aeruginosa Interaction with the Ocular Surface In Vitro and In Vivo "
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Disease Models for Therapeutic Interventional Studies
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
"Modeling Human Diseases with iPS Cells and Genetically Modified Non-Human Primates"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Strategies of Gene and Cell Therapy of Corneal Diseases Using Mouse Model"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Role of the Microbiome in the Pathogenesis of Sjogren Syndrome"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"In Vitro Modeling of Aniridia-Related Pax6 Haploinsufficiency by the Use of CRISPR/Cas9 on Limbal Epithelial Cells"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Tissue Homeostasis and Wound Healing
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"DNA Damage in the Pathogenesis of Fuchs Endothelial Corneal Dystrophy"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Attenuating Age-Related Intraepithelial Corneal Nerve Loss"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Kruppel-Like Factor 4 (KLF4) Regulates Corneal Epithelial Stratification by Controlling Cell Polarity and Plane of Cell Division"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Shp2 Protein Tyrosine Phosphatase Regulates Corneal Epithelial Stratification and Innervation"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Dissecting the Functional Role of Melanocytes in the Human Limbal Niche"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Molecular Regulation of Limbal Stem Cells"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Inhibition of Traumatic and Genetic Models of Corneal Vascularization with Overexpression of FOXC1"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genetic and Hormonal Regulation of Corneal Disease
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Elucidating the Molecular Basis of Posterior Polymorphous Corneal Dystrophy: Effects of Decreased ZEB1 Expression on Corneal Endothelial Cell Transcriptome and Function"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Advances in the Genetic Classification of Corneal Dystrophies"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Current Status of the Role of Hormones in Keratoconus"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"Aberrant DNA Methylation of miRNAs in Fuchs Endothelial Corneal Dystrophy"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure