Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: CRISPR/Personalized Medicine: Approaches for the Ocular Surface
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:20 pm
"Precision CRISPR Genome Surgery for Imprecision Medicine"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Modeling of Limbal Stem Cell Differentiation Using Human Pluripotent Stem Cells"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"3D-Printed ABCB5-Positive Stem Cells for the Treatment of Corneal Blindness"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Intrinsic Microbiome and Influences of Microbiota from Remotes Sites
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Ocular Surface Microbiome: Genomic Analysis"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Microbiome: Influence of Age/Ocular Surface Disease"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Ocular Surface Immune Transcriptome and Tear Cytokines in Corneal Infection Patient"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Corneal Immunophenotype and Homeostasis in a Mouse Model of High Fat Diet"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Commensals and the Eye: The Good and the Bad"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"The Role of the NLRP3 Inflammasome in Pseudomonas aeruginosa Keratitis"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Role of Butyrate in Maintenance of Ocular Surface Health"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Exosomes in Healthy and Diseased Ocular Surface
Session in memory of James Zieske and James Funderburgh.
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
"Regulation of Limbal Niche in Normal and Diabetic Cornea by Extracellular Vesicles"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
"Mesenchymal Stroma Cell Derived Exosomes for Corneal Repair"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
"Extracellular Vesicles for the Treatment of Corneal Scars"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Identification and Generation of Corneal Stem Cells and Their Use for Transplantation
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"The Use of Stem Cells for Corneal Disease Models and Cell Therapy"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Marking, Isolating and Transplanting Limbal Epithelial Progenitor Cells: Information Gleaned from a Colorful Biosensor Mouse"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Investigating Chondroitin Sulfate Substrates for the Cultivation of iPSC-Derived Corneal Epithelium"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Limbal Derived Mesenchymal Stem Cells in Novel Extracellular Matrix-Mimetic Hydrogel in Corneal Wound Healing"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"The Use of Small-Molecules in Modulating Limbal Stem Cell Function"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Stem Cell Tracking, Loss and Recovery in the Corneal Epithelium"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Exploring Limbal Stem Cell Hierarchical Organization Using Single-Cell RNA Sequencing"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Transcriptomics and Proteomics: Corneal Cell Types and Changes in Disease
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Uncovering Novel Cell Types in Human Corneal Limbus Using Single-Cell Transcriptomics"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"Leveraging Hundreds of Publicly Available Ocular Gene-Expression Datasets to Identify Novel Transcripts, Tissue and Temporal Gene Markers, and Provide a Community Web Resource"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
"Identifying Pathological Changes in Keratoconus Using a Multi-Omics Approach"
7:25 pm - 7:35 pm
Discussion
7:35 pm - 7:45 pm
"Multi-Omics Analyses of Microenvironment of Aqueous Humor and Corneal Endothelial Cells in Bullous Keratopathy"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Corneal Neighbors Affecting Its Function: Conjunctiva, Meibomian and Lacrimal Glands
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Effect of Inflammation and Aging on Lacrimal Gland Function"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Increased Tear Cathepsin S Drives Ocular Surface and Lacrimal Gland Inflammation"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"The Role of Corneal and Conjunctival Epithelial Dendritic Cells in Seasonal and Perennial Allergic Conjunctivitis"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Role of Primary Cilia-Mediated Signaling in Development and Regeneration of the Meibomian Glands"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Hyaluronan Regulates Meibomian Gland Morphogenesis and Homeostasis"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Conjunctival Goblet Cells Targets of Allergic and Specialized Pro-Resolving Mediators"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Corneal Sensory Nerve Activity Depends on the Presence of Resident Dendritic Cells at Basal Conditions"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Emerging Tools for Ocular Drug Delivery
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Modeling of Aniridia-Related Keratopathy and Identification of Novel Drugs for Potential Repurposing Treatment"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Strategies to Deliver Natural Compounds to the Ocular Surface"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:15 pm
"Topical Application of Polymeric Nanomicelles in Ophthalmology"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:40 pm
"Gene Therapy to the Cornea"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Immunity and Inflammation in Ocular Surface Diseases
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Innate Immunity in Microbial Keratitis"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Molecular Contributors to the Absence of a Bacterial Microbiome on the Healthy Cornea"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Differential Reponses of Tear-Film PMNs on Reactive Oxygen Species Generation"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Increase of Glycocalyx Barrier in Cornea Epithelium via Toll-Like Receptor 3 (TLR3)"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"The Ocular Response to Infection"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Role of Macrophage Populations in Herpes Virus Ocular Infection"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Corneal Epithelial Dendritic Cell Density and Morphology After 3 Months of Overnight Orthokeratology and Rigid Contact Lens Wear Compared to No Lens Wear"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
From Discovery to Clinic: Drug Testing and Regulatory Issues
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"The Liquid and Bioengineered Cornea: Stem Cells and Matrix"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"From Discovery to Clinic: Commercialising Innovations for Corneal Cell and Tissue Therapies"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
"A Novel Biomarker for Neuropathic Corneal Pain: From Bedside to Artificial Intelligence and Back"
7:25 pm - 7:35 pm
Discussion
7:35 pm - 7:45 pm
"Engineering Growth Factors for Clinical Use in Corneal Disease"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure