Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Microproteins in Medical Science
7:40 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:20 pm
"Genetic Drivers of Amino Acid Substitutants in Cancer"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Decoding the Microproteins of the Global Microbiome With Machine Learning and Gene Synteny"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"In Vivo Single-Cell CRISPR Screening for Microproteins Identifies a Critical Ribosomal Component"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Microproteins Across Evolution
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Systems Approaches to Pierce the Mysteries of De Novo Evolving smORFs"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"The evolutionary origin of microproteins"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"From Random DNA to Short Genes: Mechanisms of de Novo Gene Birth and Bacterial Anti-Phage Defense"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Systematic Functional Studies of Microproteins in Drosophila "
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"ORFs Within ORFs: Deciphering the Landscape and Mechanisms of Dual-Coding Genes in Arabidopsis"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Microproteins Simba1 and Simba2 Activate Wingless Signaling During the Reactivation of Neural Stem Cells in Drosophila"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Microproteins Across the Tree of Life
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"From Hidden to Illuminated: Exploring the Vast Small Proteome of Salmonella"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"Look! What’s Hiding in the Shade? Evolutionary Clues from Microproteins in Light-Responsive Growth"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
"Investigating the Co-Emergence of Vertebrate-Specific Microproteins and Cell States"
7:25 pm - 7:35 pm
Discussion
7:35 pm - 7:45 pm
"Roles for Microproteins Encoded by a Bicistronic RNA in Drosophila Reproduction"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Big Data for Human Microproteins
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Unlocking the Hidden Code: How Ribosome Profiling Reveals the Operating Principles of the Genome"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Systematic Approaches to Dissect the Role of Translation in "Untranslated" Regions"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Scaling the Integration of Ribosome Profiling Evidence into Ensembl Genome Annotation"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Ribo-Seq at Scale, Predicting Micropeptides from a Trillion Reads"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Enhancing and Standardizing ORF Catalogs: Ribo-Seq and Beyond for Microprotein Discovery"
11:40 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"New Paradigms for the Annotation of Translation in GENCODE"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Microproteins in Normal and Disease Biology
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Microproteins and chromatin"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"Microproteins and Metabolic Regulation"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
"Non-canonical ORFs and microproteins in childhood cancer"
7:25 pm - 7:35 pm
Discussion
7:35 pm - 7:45 pm
"Translating MBNL2: uORFs as Translational Gatekeepers or Functional Microproteins?"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Proteomics and Immunopeptidomics for Disease-Associated Microproteins
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Large-Scale Approaches to Decipher the Function and Mechanism of Nonconventional Translatome in Signal Transduction"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Noncanonical Translation as a Source of Novel Antigens"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"The Dark Genome: A Source of Protein Diversity and Tumor Antigens"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Multi-Omics Powered Identification and Validation of HLA-Bound Peptides from Microproteins"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Venturing into the Unknown: Non-Canonical HLA-Associated Antigen Target Discovery in Cancer"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Discovery and Validation of Ribo-Seq Derived Open Reading Frames using Synthetic Peptides and Mass Spectrometry"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Genome Variants, Microproteins, and Genetic Disorders
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Developing Microproteins as Therapeutic Targets for Heart Failure"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"Learning Translation: Deep Learning Guided Discovery of ORFs and Variant Interpretation"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
"Variants in Small Open Reading Frames in Rare and Common Disease"
7:25 pm - 7:35 pm
Discussion
7:35 pm - 7:45 pm
"Exploring the Clinical Relevance of Non-Canonical Open Reading Frames: Insights from Public Databases and a Cohort of Patients with Immune Disorders"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
High-Throughput Technologies for Microproteins
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Insights and Lessons From Large-Scale sORF Knockout and Overexpression Screens"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Profiling Translation in Single Cells"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"TISCA2: A Drug-Free Approach for High-Precision Mapping of Translation Initiation Sites in Mammalian Cells and Tissues"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Tissue-Wide Single-Cell CRISPR Screening for Microproteins Unveils New Layers of Ribosomal Complexity"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"An Integrative Approach to Predictive Modeling and Single-Cell Measurements of Translation"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"An Integrated National Platform for Non-Canonical Antigen Discovery and Vaccine Development in Pediatric and Adult Cancers"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Microproteins in Cancer Therapeutics
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Microproteins: Key Regulators of Cellular Plasticity in Health and Disease"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Sumoylation Shapes Intron Retention and the Generation of Non-Canonical Antigens in AML"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"The Journey Toward the Development of a Clinically Viable MYC Inhibitor"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure