| Sunday, 2 July 2000 |
| 2:00 p.m. - 11:00 p.m. |
arrival and registration |
| 6:00 p.m. |
dinner |
| 7:30 - 9:30 p.m. |
session one |
Session One, 2 July 2000, 7:30 - 9:30 p.m.
High-throughput sample preparation I
Chair: Corey Strickland, Schering Plough Research Institute |
| Time |
Speaker |
Title |
| 7:30 p.m. |
Aled Edwards, Toronto |
Lessons learned from cloning, expression and purification of thousands of proteins for structural studies |
| 8:10 p.m. |
Alan Davidson, Toronto |
Improving the solubility of proteins by mutagenesis |
| 8:50 p.m |
Frank Collart, Argonne |
Automated molecular biology for high-throughput gene cloning and expression |
| Monday, 3 July 2000 |
| 7:30 - 8:30 a.m. |
breakfast |
| 8:30 a.m. |
conference photo |
| 9:00 a.m. - 12:30 p.m. |
session two |
Session Two, 3 July 2000, 9:00 a.m. - 12:30 p.m.
High-throughput sample preparation II
Chair: Corey Strickland, Schering Plough Research Institute |
| Time |
Speaker |
Title |
| 9:00 a.m. |
Joe Luft, Hauptmann/Woodward |
High-throughput protein crystallization: keeping up with the genomics |
| 10:00 a.m. |
coffee break |
|
| 10:20 a.m. |
Thomas Friedlander, Cyberlabs |
High-throughput vapor diffusion screening |
| 11:10 a.m. |
Hidong Kim, Emerald BioStructures |
Crystal Monitor:TM an SQL relational
database application for managing protein crystallization trials |
| 12 noon |
robotics discussion |
| 12:30 - 1:30 p.m. |
lunch |
| 1:30 - 4:00 p.m. |
free time |
| 4:30 - 6:00 p.m. |
poster session |
| 6:00 p.m. |
dinner |
| 7:30 - 9:30 p.m. |
session three |
Session Three, 3 July 2000, 7:30 - 9:30 p.m.
Anomalous data collection: MAD and SIRAS
Chair: Philip Martin, Wayne State University |
| Time |
Speaker |
Title |
| 7:30 p.m. |
Thomas Terwilliger, Los Alamos |
Maximum-likelihood density modification |
| 8:00 p.m. |
Zbigniew Dauter, BNL |
Phasing by anomalous dispersion from halides |
| 8:30 p.m |
Ruslan Sanishvili, Argonne |
MAD at SBC-CAT: routine or extraordinary experiment |
| 9:00 p.m. |
Philip Martin, Wayne State |
Structure of a novel arsenic detoxification enzyme, the ArsC Arsenate Reductase at 1.16 A: MAD determination at the Cs L-I edge |
| Tuesday, 4 July 2000 |
| 7:30 - 8:30 a.m. |
breakfast |
| 9:00 a.m. - 12:30 p.m. |
session four |
Session Four, 4 July 2000, 9:00 a.m. - 12:30 p.m.
Automation of phasing and model-building
Chair: John Badger, RCSB |
| Time |
Speaker |
Title |
| 9:00 a.m. |
John Badger, RCSB |
Setting teh stage: new drivers towards automated crystallography |
| 9:10 a.m. |
Victor Lamzin, Hamburg EMBL |
Towards automated determination of protein crystal structures: the ARP/wARP approach |
| 10:00 a.m. |
coffee break |
|
| 10:30 a.m. |
Sherry Mowbray, Uppsala |
Errors and reproducibility in electron density map interpretation |
| 11:20 a.m. |
Gerard Bricogne, Cambridge |
Maximum-likelihood phasing |
| 12:30 - 1:30 p.m. |
lunch |
| 1:30 - 4:00 p.m. |
free time |
| 4:30 - 6:00 p.m. |
poster session |
| 6:00 p.m. |
dinner |
| 7:30 - 9:30 p.m. |
session five |
Session Five, 4July 2000, 7:30 - 9:30 p.m.
Innovations in structure refinement
Chair: Todd Yeates, UCLA |
| Time |
Speaker |
Title |
| 7:30 p.m. |
Martyn Winn, Daresbury |
Use of TLS parameters to model anisotropic displacements in macromolecular refinement |
| 8:00 p.m. |
Paul Adams, Lawrence Berkeley |
Application of maximum likelihood methods to structure refinement |
| 8:30 p.m |
Michael Wall, Los Alamos |
Harnessing the potential of a structure database |
| 9:00 p.m. |
Michael Chapman, Florida State |
Real Space Refinement |
| Wednesday, 5 July 2000 |
| 7:30 - 8:30 a.m. |
breakfast |
| 9:00 a.m. - 12:30 p.m. |
session six |
Session Six, 5 July 2000, 9:00 a.m. - 12:30 p.m.
Structural genomics
Chair: Thomas Terwilliger, Los Alamos |
| Time |
Speaker |
Title |
| 9:00 a.m. |
Wayne Anderson, Northwestern |
Structural genomics: what do you get? |
| 10:00 a.m. |
coffee break |
|
| 10:30 a.m. |
Osnat Herzberg, U Maryland |
Structural genomics of hypothetical proteins from Haemophilus influenzae |
| 11:30 a.m. |
Todd Yeates, UCLA |
Challenges and surprises in structural genomics |
| 12:30 - 1:30 p.m. |
lunch |
| 1:30 - 4:00 p.m. |
free time |
| 4:30 - 6:00 p.m. |
poster session |
| 6:00 p.m. |
dinner |
| 7:30 - 9:30 p.m. |
session seven |
Session Seven, 5July 2000, 7:30 - 9:30 p.m.
Scattering from noncrystalline systems
Chair: Thomas Irving, Illinois Institute of Technology |
| Time |
Speaker |
Title |
| 7:30 p.m. |
Hiro Tsuruta, Stanford |
Solution x-ray scattering from protein assemblies: time-resolved studies and complementary aspects |
| 8:05 p.m. |
break |
|
| 8:20 p.m |
Keiichi Namba, Erato, JST |
Mechanical switch with sub-Angstrom precision revealed in the atomic model of the bacterial flagellar filament |
| 9:05 p.m. |
Tom Irving, IIT |
Interesting biological problems that can be addressed using undulator radiation at the advanced photon source |
| Thursday, 6 July 2000 |
| 7:30 - 8:30 a.m. |
breakfast |
| 9:00 a.m. - 12:30 p.m. |
session eight |
Session Eight, 6 July 2000, 9:00 a.m. - 12:30 p.m.
Hot topics and hot structures
Chair: Steven Sheriff, Bristol-Myers Squibb |
| Time |
Speaker |
Title |
| 9:00 a.m. |
Helen Pace, Thomas Jefferson |
Anomalous phasing of the NitFhit Rosetta Stone protein from C. elegans |
| 10:00 a.m. |
coffee break |
|
| 10:30 a.m. |
Virginia Rath, Pfizer Pharm |
Human liver glycogen phosphorylase inhibitors bind at a new allosteric site |
| 11:10 a.m. |
Craig Kundrot, Marshall SFC |
New directions in NASA's biological crystal growth program |
| 11:40 a.m. |
highlights of poster session |
| 12:30 - 1:30 p.m. |
lunch |
| 1:30 - 4:00 p.m. |
free time |
| 4:30 - 6:00 p.m. |
poster session |
| 6:00 p.m. |
dinner |
| 7:30 - 9:30 p.m. |
session nine |
Session Nine, 6 July 2000, 7:30 - 9:30 p.m.
Convergent techniques in biophysics
Chair: Donald Caspar, Florida State |
| Time |
Speaker |
Title |
| 7:30 p.m. |
Cecile Bon, Toulouse |
Structure and dynamics of water around proteins, as seen by neutron diffraction and spectroscopy |
| 8:00 p.m. |
Brian Baker, Harvard |
Correlations of T-cell receptor structure with binding thermodynamics and kinetics |
| 8:30 p.m |
Karin Reinisch, Harvard |
The 3.6A structure of the reovirus core |
| 9:00 p.m. |
Donald Caspar, Florida State |
wrapup |
| Friday, 7 July 2000 |
| 7:30 - 8:30 a.m. |
breakfast |
| 9:00 a.m. |
bus departs |
|
