| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Introductory Comments by GRC Site Staff |
| 7:40 pm - 7:50 pm | Welcome by the Chair, Anastassis Perrakis (The Netherlands Cancer Institute) |
| 7:50 pm - 9:30 pm | Structures for Understanding Cell Biology |
| Discussion Leader: Ana Gonzales (Stanford Synchrotron Radiation Lightsource) |
| 7:50 pm - 8:30 pm | John Kuriyan (UC Berkeley)
"Structural Mechanisms in Protein Kinase Switching" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:20 pm | Randy Read (University of Cambridge)
"Insights from Difficult Structure Determinations" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | X-Ray Free Electron Lasers on the Move |
| Discussion Leader: Ilme Schilchting (University of Heidelberg) |
| 9:00 am - 9:35 am | Dwayne Miller (Max Planck Institute for the Structure and Dynamics of Matter)
"Femtosecond Crystallography with Ultrabright Electrons and X-Rays: Capturing Chemistry in Action"
|
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Coffee Break |
| 10:15 am - 10:50 am | Aina Cohen (Stanford Synchrotron Radiation Lightsource)
"Goniometer-Based Diffraction Studies of Single Crystals at LCLS" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:35 am | Graeme Winter (Diamond Light Source)
"DIALS: Diffraction Integration for Advanced Light Sources" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:20 pm | John Spence (NSF BioXFEL Science and Technology Center)
"The NSF BioXFEL STC - Projects and New Ideas" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | New Instruments and Ideas for Diffraction Experiments |
| Discussion Leader: Thomas Schneider (EMBL Hamburg) |
| 7:30 pm - 8:00 pm | Gwyndaf Evans (Diamond Light Source)
"Approaching Submicron Macromolecular Crystallography with Synchrotron Radiation" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Bob Fischetti (Gm/CA - Argonne National Laboratory)
"Crystallography Opportunities on 4th Generation Storage Ring Synchrotron Radiation Sources" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Flora Meilleur (North Carolina State University)
"IMAGINE: Locating Hydrogen Atoms in Enzymes Using Neutron Protein Crystallography" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Growing Crystals for the New Generation Experiments |
| Discussion Leader: Janet Newman (CSIRO) |
| 9:00 am - 9:35 am | John Hunt (Columbia University)
"Rational Engineering of Improved Protein Crystallization" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Coffee Break |
| 10:15 am - 10:50 am | Jose Antonio Marquez (EMBL Grenoble)
"Integrated Crystallization and X-Ray Data Collection: Automated Crystal Mounting and Processing" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:35 am | Michael Duszenko (University of Tuebingen)
"In Vivo Crystal Formation in SF9 Insect Cells and Their Structural Analysis" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:20 pm | Edward Snell (Hauptman-Woodward Medical Research Institute)
"Methods for the Rapid Detection and Optimization of Submicron Crystals"
|
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | From Diffraction Data to Density Maps |
| Discussion Leader: Paul Adams (Lawrence Berkeley Lab) |
| 7:30 pm - 8:00 pm | Clemens Vonrhein (Global Phasing Ltd)
"Data Collection on Modern Synchrotrons: Strategies and Data Processing Revisited" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Airlie McCoy (University of Cambridge)
"The Expected LLG in Action" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Brent Nannenga (Janelia Farm)
"Protein Structure Determination by MicroED" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | From Density Maps to Structural Models |
| Discussion Leader: Robert Sweet (Brookhaven National Laboratory) |
| 9:00 am - 9:35 am | Tom Terwilliger (Los Alamos National Laboratory)
"Solving Structures with Weak Molecular Replacement or Anomalous Signal" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Coffee Break |
| 10:15 am - 10:50 am | Garib Murshudov (MRC-LMB)
"Tools for Refinement of Low Resolution Crystal Structures and Fitting into EM Maps" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:35 am | Paul Emsley (MRC-LMB)
"Low Resolution and EM Model-Building with Coot" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:20 pm | Gerard Kleywegt (PDBe, EMBL-EBI)
"The Wonderful World of Structure Archiving - What's Happening and What's Next" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 7:30 pm - 9:30 pm | Scattering Methods |
| Discussion Leader: Tom Peat (CSIRO) |
| 7:30 pm - 8:00 pm | Peter Zwart (Lawrence Berkeley National Laboratories)
"Fluctuation Scattering" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Michal Hammel (Lawrence Berkeley National Laboratory)
"SAXS, Crystallography and Computation: Accurate Structures, Conformations and Assemblies" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Meindert Lamers (MRC-LMB)
"The Bacterial DNA Replication Machinery: A Combined SAXS and EM Study" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | New Cool Methods and Hot New Structures |
| Discussion Leader: Elspeth Garman (University of Oxford) |
| 9:00 am - 9:15 am | Afonine Pavel (LBNL)
"FEM: Feature Enhanced Map"
|
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Felix Jan (L-ProBE, Ghent University)
"Structure of the Human CSF-1: CSF-1R Signalling Complex"
|
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Helen Ginn (Oxford University)
"Excel with XFEL: How the FEL Did We Get a 1.74 Å Structure?"
|
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 10:45 am | Flora Groothuizen (Netherlands Cancer Institute)
"How the Sliding Clamp Activates MutL in DNA Mismatch Repair"
|
| 10:45 am - 10:50 am | Discussion |
| 10:50 am - 11:05 am | James Holton (UCSF/LBNL)
"Optimizing Anomalous Signals Using Soft X-Rays"
|
| 11:05 am - 11:10 am | Discussion |
| 11:10 am - 11:25 am | Artem Lyubimov (Stanford, HHMI)
"X-Ray Analysis of Protein Microcrystals in a Microfluidic Trap Array"
|
| 11:25 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Anne Tuukkanen (EMBL Hamburg)
"Validation of SAXS-Based Models of Biomacromolecular Assemblies"
|
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Andrew Van Benschoten (UCSF)
"X-Ray Structure Refinement Through Diffuse Scatter Analysis"
|
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Ansuman Biswas (Indian Institute of Science)
"Functional Movements in Thymidylate Kinase from S. tokodaii"
|
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Structural Biology Accelerating Drug Development |
| Discussion Leader: Lisa Keefe (IMCA-CAT, Argonne National Laboratory) |
| 7:30 pm - 8:00 pm | Giovanna Scapin (Merck USA)
"Structural Chemistry and Drug Discovery at Merck" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Adnane Achour (Karolinska Institute)
"Structural Basis Underlying Increased TCR Recognition" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Gary Gililland (Janssen Research & Development)
"Integrating Structural Biology into Antibody Engineering" |
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |