Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Inherent Genomic Stability and
Instability |
| Discussion Leader: Sergei Mirkin (Tufts University, USA) |
7:40 pm - 7:50 pm | Opening Remarks |
7:50 pm - 8:30 pm | Philip Hanawalt (Stanford University, USA) "From Repair Replication to R-Loops in Half-a-Century" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Stephen Kowalczykowski (University of California, Davis, USA) "Molecular Functions of BRCA1, BRCA2, and RAD51 Paralogs in Homologous Recombination" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Genome Weak Links |
| Discussion Leader: Richard Wood (University of Texas MD Anderson Cancer Center, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:30 am | Richard Wood (University of Texas MD Anderson Cancer Center, USA) "Expanding
the Repertoire of Replicative DNA Polymerases" |
9:30 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Catherine Freudenreich (Tufts University, USA) "Transcriptional Effects on CAG Repeat Instability and Fragility" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Karen Vasquez (The University of Texas at Austin, USA) "Replication-Dependent
and Replication-Independent Models of DNA Structure-Induced Genetic Instability" |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:55 am | Coffee Break |
10:55 am - 11:15 am | Susan Lovett (Brandeis University, USA) "Template-Switch Mutagenesis
and Genetic Rearrangements During DNA Repair" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Thomas Petes (Duke University, USA) "DNA Structure-Based Determinants of Mutation Rates in Yeast" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | Nancy Maizels (University of Washington, USA) "Repair at DNA Nicks" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Selected from Poster Abstracts: Sheroy Minocherhomji (University of Copenhagen, Denmark) "Mitotic DNA Repair Synthesis Protects Against Chromosome Fragility" |
12:20 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Environmental and Endogenous DNA Damage |
| Discussion Leader: Nicholas Geacintov (New York University, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Nicholas Geacintov (New York University, USA) "Removal of Environmental
DNA Damage by Competing BER and NER Pathways" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Isao Kuraoka (Osaka University, Japan) "Function of Human Endonuclease V: From DNA to RNA" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:35 pm | Selected from Poster Abstracts: Xiaohua Wu (The Scripps Research Institute, USA) "Repair of DNA Double-Strand Breaks Associated with Re-Replication" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | John Tainer (University of Texas MD Anderson Cancer Center, USA) "Nucleases Sculpt DNA to Control Outcomes at Replication Forks and Double-Strand Breaks" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | David Pellman (Dana-Farber Cancer Institute, USA) "Nuclear Organization and Genome Stability" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | RNA-DNA Interplay in Genome Instability |
| Discussion Leader: Hannah Klein (New York University School of Medicine, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:30 am | Hannah Klein (New York University School of Medicine, USA) "Ribonucleotide-Promoted Genome Instability" |
9:30 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Mark Bedford (University of Texas MD Anderson Cancer Center, USA) "The Link Between Arginine Methylation
and R-Loop Resolution" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Francesca Storici (Georgia Institute of Technology, USA) "DNA Self-Repair by Transcript RNA" |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:55 am | Coffee Break |
10:55 am - 11:15 am | Karlene Cimprich (Stanford University School of Medicine, USA) "RNA Meets DNA: Mechanisms for Transcription-Associated Genome Instability" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Andres Aguilera (University of Seville, Spain) "Role of Chromatin and the DNA Damage Response in Transcription-Associated Genome Instability" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | Evgeny Nudler (New York University School of Medicine, USA) "New Principles of Transcription-Coupled DNA Repair" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Selected from Poster Abstracts: Giordano Liberi (L'Istituto di Genetica Molecolare (IGM), CNR, Italy) "Mechanisms that Rescue Replication Forks Arrested by Transcription" |
12:20 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Oxidative DNA Damage and Base Excision Repair |
| Discussion Leader: Samuel Wilson (National Institute of Environmental Health Sciences, NIH, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Samuel Wilson (National Institute of Environmental Health Sciences, NIH, USA) "Mechanistic Studies of Base Excision Repair" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Cynthia McMurray (Lawrence Berkeley National Laboratory, USA) "Death by DNA Repair" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:45 pm | Yuan Liu (Florida International University, USA) "DNA Base Lesion Repair and Trinucleotide Repeat Instability" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:10 pm | Guoliang Xu (Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China) "Enzymatic DNA Oxidation in Epigenetic Regulation of Mammalian Development" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Selected from Poster Abstracts: James Cleaver (University of California, San Francisco, USA) "Why Cockayne Patients Do Not Get Cancer Despite Their DNA Repair Deficiency" |
9:25 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mutagenesis in Response to Arrested
Replication |
| Discussion Leader: Wei Yang (National Institutes of Health, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:30 am | Wei Yang (National Institutes of Health, USA) "Tripartite DNA Lesion Recognition and Verification by XPC, TFIIH and XPA in Nucleotide Excision Repair" |
9:30 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Simon Boulton (The Francis Crick Institute, United Kingdom) "Genome Stability and the Control of Homologous Recombination" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Massimo Lopes (University of Zurich, Switzerland) "Replication Fork Remodelling upon DNA Replication Stress" |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:55 am | Coffee Break |
10:55 am - 11:15 am | Naoko Shima (University of Minnesota, USA) "Functional Interactions Between Dormant Origins and BRCA2 in Genome Stability and Mouse Development" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Frederick Alt (Harvard Medical School, USA) "Chromosomal Loop Domains, DNA Breaks and Translocations in Lymphoid and Neural Cells" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | Kirill Lobachev (Georgia Institute of Technology, USA) "Mechanism of Endogenous and Damage-Induced Mutagenesis in Palindrome-Proximal Regions" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Selected from Poster Abstracts: Duncan Smith (New York University, USA) "Pif1 Helicases Suppress Widespread Replisome Pausing at tRNA Genes in S. cerevisiae" |
12:20 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Checkpoints and Strand-Break Repair |
| Discussion Leader: Karlene Cimprich (Stanford University School of Medicine, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Lee Zou (Massachusetts General Hospital Cancer Center, Harvard University, USA) "New Insights into the Functions
of ATR in DNA Repair" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Dale Ramsden (University of North Carolina, Lineberger Comprehensive Cancer Center, USA) "The Contribution of DNA Polymerases to Double Strand Break Repair" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:45 pm | Sylvie Doublie (University of Vermont, USA) "When the 3'-End Justifies the Means, or How a Family A Polymerase Solves a Major Challenge" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:10 pm | Mitch McVey (Tufts University, USA) "Meaningful Mistakes: Using Translesion Polymerases During Double-Strand Break Repair" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Selected from Poster Abstracts: Richard Pomerantz (Temple University Lewis Katz School of Medicine, USA) "New Mechanisms of Polymerase Theta-Mediated End-Joining" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | FoSTeS, Kataegis and Chromothripsis |
| Discussion Leader: Anna Malkova (University of Iowa, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:30 am | Anna Malkova (University of Iowa, USA) "Genetic Instability Resulting from DNA Synthesis Associated with Double-Strand Break Repair" |
9:30 am - 9:35 am | Discussion |
9:35 am - 9:55 am | James Lupski (Baylor College of Medicine, USA) "Mechanisms for Disease Associated Genomic Rearrangements" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Thanos Halazonetis (University of Geneva, Switzerland) "Mechanisms of Oncogene-Induced DNA Replication Stress" |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:35 am | Selected from Poster Abstracts: Jane Kim (Tufts University, USA) "Break-Induced Replication Drives Large-Scale CAG Repeat Expansion in Budding Yeast" |
10:35 am - 10:40 am | Discussion |
10:40 am - 11:10 am | Coffee Break |
11:10 am - 11:30 am | Youri Pavlov (UNMC Eppley Cancer Center, University of Nebraska, USA) "En Route to APOBEC-Induced Mutation Clusters" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Lawrence Loeb (University of Washington, USA) "Extensive Subclonal Mutations Characterize Many Human Cancers; Origin and Consequences" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Selected from Poster Abstracts: Ashok Bhagwat (Wayne State University, USA) "DNA Damage at the Replication Fork: The Role of APOBEC Enzymes" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Selected from Poster Abstracts: Robert P. Fuchs (CNRS UMR7258, France) "Gymnastics Between Sister Chromatids and Timing of Events at the Replication Fork Upon Encounter of a Replication-Blocking Lesion in E. coli" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Emerging Therapies Based on Cancer Genomics |
| Discussion Leader: Thomas Helleday (Karolinska Institutet, Sweden) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Thomas Helleday (Karolinska Institutet, Sweden) "Targeting DNA Repair to Poison Cells with Damaged Nucleosides" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Zvi Livneh (Weizmann Institute of Science, Israel) "Harnessing DNA Repair for Cancer Prevention and Early Detection" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:45 pm | Tarun Kapoor (The Rockefeller University, USA) "Chemical Proteomics: Shining Light on Phosphorylation-Dependent Protein-Protein Interactions Required for Genome Stability" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:10 pm | James Ford (Stanford University School of Medicine, USA) "Chemoprevention Targeting
BRCA1-Mutation Associated DNA Repair Defects" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Selected from Poster Abstracts: Menachem Rubinstein (Weizmann Institute of Science, Israel) "Programmed DNA Damage: Potential Clinical Implications" |
9:25 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |